Format:
Online-Ressource
ISSN:
1099-0690
Content:
Abstract: We have defined the complete structure and assessed the biological activity of the lipopolysaccharide (LPS) from Alkalimonas delamerensis, an alkaliphilic bacterium isolated from soda lakes in China and East Africa. The structural determination, which was achieved by the use of chemical, spectroscopic and spectrometric approaches, indicates a novel Rough type lipopolysaccharide that is rich in negatively charged groups in the lipid A inner core region. The proinflammatory activity of the pure lipopolysaccharide has also been defined by testing the LPS as a stimulant in human HEK293 cells, which express the CD14/MD2/TLR4 complex (HEK293‐hTLR4), and in bone marrow‐derived macrophages.
In:
volume:2013
In:
number:13
In:
year:2013
In:
pages:2653-2665
In:
extent:13
In:
European journal of organic chemistry, Weinheim : Wiley-VCH Verl., 1998-, 2013, Heft 13 (2013), 2653-2665 (gesamt 13), 1099-0690
Language:
English
DOI:
10.1002/ejoc.201201702
URN:
urn:nbn:de:101:1-2023020507090996495789
URL:
https://doi.org/10.1002/ejoc.201201702
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023020507090996495789
URL:
https://d-nb.info/1280106476/34
URL:
https://doi.org/10.1002/ejoc.201201702
Bookmarklink