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Tannic Acid Lipid Nanoparticles can Deliver Messenger RNA Payloads and Improve their Endosomal Escape (2023)

Ma, Yutian [Verfasser] ; Fenton, Owen S. [Verfasser]

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UID:

(DE-101)1286858526

Format: Online-Ressource

ISSN: 2366-3987

Content: Abstract: Even though lipid nanoparticles (LNPs) can deliver messenger RNA (mRNA) payloads into cells, their efficiency is often limited by endosomal trapping which prevents RNA payloads from acting therapeutically. Improving the percentage of RNA LNPs that can escape from endosomes and enter the cytoplasm is therefore an area of active research interest that could lead to improved safety profiles and reduced manufacturing costs of mRNA drugs. Here, tannic acid mRNA LNPs [TA (+) mRNA LNPs] are reported as an effective delivery platform for the delivery of mRNA payloads. The formulation, characterization, and stability of TA (+) mRNA LNPs are described; two different approaches via confocal microscopy are then utilized to quantify the endosomal escape of the TA (+) mRNA LNPs; and lastly, the biodistribution and tolerability of the TA (+) mRNA LNPs are evaluated in mice following intravenous and intramuscular dosing regimens. To isolate the effect that TA imparts on each of these properties, mRNA LNPs that do not contain TA [TA (−) mRNA LNPs] are evaluated side‐by‐side in each of these studies. A collective analysis of these results suggests that TA (+) mRNA LNPs are effective carriers for mRNA payloads and that the incorporation of TA within each formulation improves the endosomal escape of mRNA LNPs.

In: day:21

In: month:04

In: year:2023

In: extent:8

In: Advanced therapeutics, Weinheim : Wiley-VCH Verlag, [2018]-, (21.04.2023) (gesamt 8), 2366-3987

Language: English

DOI: 10.1002/adtp.202200305

URN: urn:nbn:de:101:1-2023042415493508016247

URL: https://doi.org/10.1002/adtp.202200305

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023042415493508016247

URL: https://d-nb.info/1286858526/34

URL: https://doi.org/10.1002/adtp.202200305

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ChemInform Abstract: Efficient Catalyst Turnover in the Phosphitylation of Alcohols with Phosphoramidites. (2009)

Brady, Patrick B. [Verfasser] ; Morris, Elizabeth M. [Verfasser] ; Fenton, Owen S. [Verfasser] ; [et al.]

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UID:

(DE-101)128847962X

Format: Online-Ressource

ISSN: 1522-2667

Content: Abstract: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

In: volume:40

In: number:23

In: year:2009

In: pages:no-no

In: extent:1

In: ChemInform, Weinheim : Wiley-VCH, 1987-2016, 40, Heft 23 (2009), no-no (gesamt 1), 1522-2667

Language: English

DOI: 10.1002/chin.200923177

URN: urn:nbn:de:101:1-2023050706150424456886

URL: https://doi.org/10.1002/chin.200923177

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023050706150424456886

URL: https://d-nb.info/128847962X/34

URL: https://doi.org/10.1002/chin.200923177

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Polymers for extended-release administration (2019)

Paolini, Marion S. [Verfasser] ; Fenton, Owen S. [Verfasser] ; Bhattacharya, Chandrabali [Verfasser] ; [et al.]

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UID:

(DE-101)118470080X

Format: Online-Ressource , online resource.

ISSN: 1572-8781 , 1572-8781

In: volume:21

In: number:2

In: day:8

In: month:4

In: year:2019

In: pages:1-24

In: date:6.2019

In: Biomedical microdevices, Dordrecht [u.a.] : Springer Science + Business Media B.V, 1998-, 21, Heft 2 (8.4.2019), 1-24, 6.2019, 1572-8781

Language: English

DOI: 10.1007/s10544-019-0386-9

URN: urn:nbn:de:101:1-2019042719265967541059

URL: https://doi.org/10.1007/s10544-019-0386-9

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2019042719265967541059

URL: https://d-nb.info/118470080X/34

URL: https://doi.org/10.1007/s10544-019-0386-9

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Novel Use of Dairy Processing Sludge Derived Pyrogenic Char (DPS-PC) to Remove Phosphorus in Discharge Effluents (2019)

Ashekuzzaman, S. M. [Verfasser] ; Kwapinska, Marzena [Verfasser] ; Leahy, J. J. [Verfasser] ; [et al.]

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UID:

(DE-101)1198381280

Format: Online-Ressource , online resource.

ISSN: 1877-265X , 1877-265X

In: day:1

In: month:7

In: year:2019

In: pages:1-13

In: Waste and biomass valorization, [Dordrecht] : Springer Netherlands, 2010-, (1.7.2019), 1-13, 1877-265X

Language: English

DOI: 10.1007/s12649-019-00731-9

URN: urn:nbn:de:101:1-2019103020571702195502

URL: https://doi.org/10.1007/s12649-019-00731-9

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2019103020571702195502

URL: https://d-nb.info/1198381280/34

URL: https://doi.org/10.1007/s12649-019-00731-9

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〈〈The〉〉 yeomen of the guard (1993)

Sullivan, Arthur S. [Geistiger Schöpfer] ; Gilbert, William S. ; Fieldsend, David [Tenor] ; [et al.]

[S.l.] : Jay Productions

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UID:

(DE-605)TT000028360

Format: 2 CD + Beil.

Note: Interpr.: Fieldsend, David [Ten] * Gray, Fenton [Gsg] * Maxwell, Donald [Bar] ... D'Oyly Carte Opera Company 〈London〉 / Chorus * D'Oyly Carte Opera Company 〈London〉 / Orchestra * Edwards, John Owen [Dir]

Language: Undetermined

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ChemInform Abstract: Catalytic Lewis Acid Phosphorylation with Pyrophosphates. (2013)

Fenton, Owen S. [Verfasser] ; Allen, Emily E. [Verfasser] ; Pedretty, Kyle P. [Verfasser] ; [et al.]

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UID:

(DE-101)1280515376

Format: Online-Ressource

ISSN: 1522-2667

Content: Abstract: This is a useful method for phosphorylation of primary and secondary alcohols.

In: volume:44

In: number:10

In: year:2013

In: pages:no-no

In: extent:1

In: ChemInform, Weinheim : Wiley-VCH, 1987-2016, 44, Heft 10 (2013), no-no (gesamt 1), 1522-2667

Language: English

DOI: 10.1002/chin.201310036

URN: urn:nbn:de:101:1-2023020905525336477623

URL: https://doi.org/10.1002/chin.201310036

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023020905525336477623

URL: https://d-nb.info/1280515376/34

URL: https://doi.org/10.1002/chin.201310036

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Nanoparticle‐Mediated Delivery of Anti‐PU.1 siRNA via Localized Intracisternal Administration Reduces Neuroinflammation (2023)

Ralvenius, William T. [Verfasser] ; Andresen, Jason L. [Verfasser] ; Huston, Margaret M. [Verfasser] ; [et al.]

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UID:

(DE-101)1312733233

Format: Online-Ressource

ISSN: 1521-4095

Content: Abstract: Neuroinflammation is a hallmark of neurodegenerative disorders including Alzheimer's disease (AD). Microglia, the brain's immune cells, express many of the AD‐risk loci identified in genome wide association studies and present a promising target for anti‐inflammatory RNA therapeutics but are difficult to transfect with current methods. Here, several lipid nanoparticle (LNP) formulations are examined, and a lead candidate that supports efficient RNA delivery in cultures of human stem cell‐derived microglia‐like cells (iMGLs) and animal models of neuroinflammation is identified. The lead microglia LNP (MG‐LNP) formulation shows minimal toxicity and improves delivery efficiency to inflammatory iMGLs, suggesting a preference for delivery into activated microglia. Intraperitoneal injection of the MG‐LNP formulation generates widespread expression of the delivered reporter construct in all organs, whereas local intracisternal injection directly into the cerebrospinal fluid leads to preferential expression in the brain. It is shown that LNP‐mediated delivery of siRNA targeting the PU.1 transcription factor, a known AD‐risk locus, successfully reduces PU.1 levels in iMGLs and reduces neuroinflammation in mice injected with LPS and in CK‐p25 mice that mimic the chronic neuroinflammation seen in AD patients. The LNP formulation represents an effective RNA delivery vehicle when applied intrathecally and can be broadly utilized to test potential neuroinflammation‐directed gene therapies.

In: day:08

In: month:12

In: year:2023

In: extent:13

In: Advanced materials, Weinheim : Wiley-VCH, 1989-, (08.12.2023) (gesamt 13), 1521-4095

Language: English

DOI: 10.1002/adma.202309225

URN: urn:nbn:de:101:1-2023120914244996242444

URL: https://doi.org/10.1002/adma.202309225

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023120914244996242444

URL: https://d-nb.info/1312733233/34

URL: https://doi.org/10.1002/adma.202309225

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Phosphorus fertiliser equivalent value of dairy processing sludge‐derived STRUBIAS products using ryegrass (Lolium perenne L.) and spring wheat (Triticum aestivum) (2023)

Shi, W. [Verfasser] ; Fenton, Owen [Verfasser] ; Ashekuzzaman, S. M. [Verfasser] ; [et al.]

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UID:

(DE-101)1312978767

Format: Online-Ressource

ISSN: 1522-2624

Content: Background: Struvite, biochar and ash products (collectively known as STRUBIAS) derived from different waste streams are used as fertilisers in agriculture. Raw dairy processing sludge (DPS) shows promise as bio‐based fertilisers, but secondary STRUBIAS‐derived products need further testing as fertilisers. Aims: The objective of this study was to calculate the phosphorus mineral fertiliser equivalency (P‐MFE) for some STRUBIAS products derived from DPS. Methods: Ryegrass (Lolium perenne L.) and wheat (Triticum aestivum) pot trials were used to determine the P‐MFE using the apparent P recovery (APR) method for Fe‐DPS and DPS‐derived struvites (Struvite 1–4), hydrochars (HC1–3) and ash. Results: The tested STRUBIAS products can be divided into two groups: (1) a range of products that can (i.e. Struvite 1–3) and (2) cannot (i.e. Struvite 4, HC1–3, ash and Fe‐DPS) be considered fertilisers. In the first group, the P‐MFE ranged from 66.8% to 76.7% for ryegrass and from 77.9% to 93.5% for spring wheat grain. In the second group, the P‐MFE ranged from 7.8% to 58.3% for ryegrass and from −34.5% to −151.3% for spring wheat grain. The negative agronomic effects of some products for wheat grain (struvite and HC) in this study were mainly caused by high Fe content, which could be overcome by improved treatment processes. Conclusions: Future policy and research must be aware that not all the DPS‐derived STRUBIAS products are suitable as fertilisers and therefore need to be tested individually.

In: day:11

In: month:12

In: year:2023

In: extent:10

In: Journal of plant nutrition and soil science, Weinheim : Wiley-VCH, 1922-, (11.12.2023) (gesamt 10), 1522-2624

Language: English

DOI: 10.1002/jpln.202300164

URN: urn:nbn:de:101:1-2023121114441634259537

URL: https://doi.org/10.1002/jpln.202300164

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023121114441634259537

URL: https://d-nb.info/1312978767/34

URL: https://doi.org/10.1002/jpln.202300164

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Enhancing the Functionality of Immunoisolated Human SC‐βeta Cell Clusters through Prior Resizing (2024)

Bochenek, Matthew A. [Verfasser] ; Walters, Ben [Verfasser] ; Zhang, Jingping [Verfasser] ; [et al.]

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UID:

(DE-101)1315798840

Format: Online-Ressource

ISSN: 1613-6829

Content: Abstract: The transplantation of immunoisolated stem cell derived beta cell clusters (SC‐β) has the potential to restore physiological glycemic control in patients with type I diabetes. This strategy is attractive as it uses a renewable β‐cell source without the need for systemic immune suppression. SC‐β cells have been shown to reverse diabetes in immune compromised mice when transplanted as ≈300 µm diameter clusters into sites where they can become revascularized. However, immunoisolated SC‐β clusters are not directly revascularized and rely on slower diffusion of nutrients through a membrane. It is hypothesized that smaller SC‐β cell clusters (≈150 µm diameter), more similar to islets, will perform better within immunoisolation devices due to enhanced mass transport. To test this, SC‐β cells are resized into small clusters, encapsulated in alginate spheres, and coated with a biocompatible A10 polycation coating that resists fibrosis. After transplantation into diabetic immune competent C57BL/6 mice, the “resized” SC‐β cells plus the A10 biocompatible polycation coating induced long‐term euglycemia in the mice (6 months). After retrieval, the resized A10 SC‐β cells exhibited the least amount of fibrosis and enhanced markers of β‐cell maturation. The utilization of small SC‐β cell clusters within immunoprotection devices may improve clinical translation in the future.

In: day:11

In: month:01

In: year:2024

In: extent:12

In: Small, Weinheim : Wiley-VCH, [2005]-, (11.01.2024) (gesamt 12), 1613-6829

Language: English

DOI: 10.1002/smll.202307464

URN: urn:nbn:de:101:1-2024011214231893756297

URL: https://doi.org/10.1002/smll.202307464

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2024011214231893756297

URL: https://d-nb.info/1315798840/34

URL: https://doi.org/10.1002/smll.202307464

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Biomanufacturing for clinically advanced cell therapies (2018)

Aijaz, Ayesha [Verfasser] ; Li, Matthew [Sonstige] ; Smith, David [Sonstige] ; [et al.]

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UID:

(DE-101)1164352199

Format: Online-Ressource , online resource.

ISSN: 2157-846X , 2157-846X

In: volume:2

In: number:6

In: day:11

In: month:6

In: year:2018

In: pages:362-376

In: date:6.2018

In: Nature biomedical engineering, London ; New York NY ; Tokyo : Nature Research, 2016-, 2, Heft 6 (11.6.2018), 362-376, 6.2018, 2157-846X

Language: English

DOI: 10.1038/s41551-018-0246-6

URN: urn:nbn:de:101:1-2018081217155718989459

URL: https://doi.org/10.1038/s41551-018-0246-6

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2018081217155718989459

URL: https://d-nb.info/1164352199/34

URL: http://dx.doi.org/10.1038/s41551-018-0246-6

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