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  • 1
    Book
    Book
    Neurodegenerative diseases : clinical aspects, molecular genetics and biomarkers (2014)
    London [u.a.] : Springer
    Details
    UID:
    (DE-605)HT018274153
    Format: XIX, 253 S. : Ill. , 24 cm
    ISBN: 9781447163794
    Note: Includes bibliographical references
    Additional Edition: Erscheint auch als Online-Ausgabe 9781447163800
    Language: English
    URL: Inhaltsverzeichnis
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    Book
    HBZ
  • 2
    Online Resource
    Online Resource
    Neurodegenerative Diseases : Clinical Aspects, Molecular Genetics and Biomarkers (2014)
    London : Springer London
    Details
    UID:
    (DE-604)BV041881576
    Format: 1 Online-Ressource
    ISBN: 9781447163794 , 9781447163800
    Note: Lizenzpflichtig
    Language: English
    DOI: 10.1007/978-1-4471-6380-0
    URN: urn:nbn:de:1111-2014042476
    URL: Volltext
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    Online Access
    Open Access Request
    BVB
  • 3
    Book
    Book
    Biomarkers for early diagnosis of Alzheimer’s disease (2008)
    New York : Nova Biomed. Books
    Details
    UID:
    (DE-605)HT016014766
    Format: VI, 307 S. : Ill., graph. Darst.
    ISBN: 9781604569919 , 1604569913
    Series Statement: Nova biomedical
    Language: English
    URL: Inhaltsverzeichnis
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  • 4
    Book
    Book
    Neurodegenerative diseases : clinical aspects, molecular genetics and biomarkers (2014)
    London [u.a.] : Springer
    Details
    UID:
    (DE-627)1609454820
    Format: XIX, 253 S.
    ISBN: 9781447163794
    Additional Edition: 9781447163800
    Additional Edition: Erscheint auch als Online-Ausgabe Galimberti, Daniela Neurodegenerative Diseases London : Springer London, 2014 9781447163800
    Language: English
    Subjects: Medicine
    RVK:
    YG 4001
    Keywords: Nervendegeneration
    URL: Cover
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  • 5
    E-Resource
    E-Resource
    Neurodegenerative diseases : clinical aspects, molecular genetics and biomarkers (2014)
    London : Springer
    Details
    UID:
    (DE-605)HT018537386
    ISBN: 9781447163800 , 9781447163794
    Content: This book gives an overview of the current knowledge on the most common neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and additional neurodegenerative diseases. Different aspects of each disease are reviewed, including clinical issues, treatments, basic discoveries (genetics and molecular biology), and translation of basic research into biomarkers for early diagnosis. In addition, emerging data indicate that neurodegeneration seems to also be present in classically non-degenerative disorders. Therefore, a chapter about overlapping mechanisms between dementias and psychiatric disorders is included, as well as a description of the role of neurodegeneration in multiple sclerosis.   Neurodegenerative Diseases is aimed at clinicians, particularly those working in academic hospitals. This multidisciplinary book will also be of interest to basic researchers in medical fields
    Language: English
    Keywords: Nervendegeneration ; Online-Ressource
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  • 6
    Online Resource
    Online Resource
    Neurodegenerative Diseases : Clinical Aspects, Molecular Genetics and Biomarkers (2018)
    Cham : Springer International Publishing
    Details
    UID:
    (DE-605)HT019641515
    Format: 1 Online-Ressource (X, 407 p. 23 illus., 20 illus. in color)
    Edition: 2nd ed. 2018
    ISBN: 9783319729381
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783319729374
    Language: English
    DOI: 10.1007/978-3-319-72938-1
    URL: http://dx.doi.org/10.1007/978-3-319-72938-1
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    Online Resource
    Open Access Request
    HBZ
  • 7
    Online Resource
    Online Resource
    Neurodegenerative Diseases : Clinical Aspects, Molecular Genetics and Biomarkers (2018)
    Cham : Springer International Publishing
    Details
    UID:
    (DE-604)BV044888707
    Format: 1 Online-Ressource (X, 407 p. 23 illus., 20 illus. in color)
    Edition: 2nd ed.
    ISBN: 9783319729381
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-319-72937-4
    Language: English
    DOI: 10.1007/978-3-319-72938-1
    URL: Volltext  (URL des Erstveröffentlichers)
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Online Access
    Open Access Request
    BVB
  • 8
    Online Resource
    Online Resource
    Biomarkers for early diagnosis of Alzheimer's disease (2008)
    New York : Nova Biomedical Books
    Details
    UID:
    (DE-604)BV044087632
    Format: vi, 307 p.
    ISBN: 9781608763177
    Note: Includes bibliographical references and index
    Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 1-60456-991-3
    Additional Edition: Erscheint auch als Druck-Ausgabe, Hardcover ISBN 978-1-60456-991-9
    Language: English
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    Online Resource
    BVB
  • 9
    Online Resource
    Online Resource
    Neurodegenerative Diseases : Clinical Aspects, Molecular Genetics and Biomarkers (2014)
    London : Springer London, Limited
    Details
    UID:
    (DE-627)174619751X
    Format: 1 online resource (266 pages)
    Edition: 1st ed.
    ISBN: 9781447163800
    Content: Covers clinical and genetic aspects, as well as biomarkers for early diagnosis and treatment Translational (from bench to bedside) approach Includes chapters on neurodegeneration in classically non-degenerative disorders.
    Content: Intro -- Preface -- Abbreviations -- Contents -- Contributors -- Chapter 1: Genetics and Epigenetics: Basic Concepts -- Introduction -- Genetics -- Classes of Human Genetic DNA Variations -- Restriction Fragment Length Polymorphisms -- Variable Number of Tandem Repeats -- Copy-Number Variation -- The Evolution of the Genetic Analysis of Complex Traits -- Genetic Linkage Analyses -- Genome-Wide Association Study -- Next-Generation Sequencing -- Genetics and Neurological Disorders -- Epigenetics -- DNA Methylation -- Histone Modification -- MicroRNA-Associated Gene Silencing -- Beyond Genetic Variation: A Role for Epigenetics in Neurodegenerative Diseases? -- Technologies Used in Epigenetic Studies -- References -- Chapter 2: Alzheimer's Disease: Clinical Aspects and Treatments -- Introduction and Epidemiology -- Clinical Aspects -- Mild Cognitive Impairment -- Diagnostic Criteria -- Treatment -- The Cholinergic Hypothesis -- The Amyloid Hypothesis -- Atypical Forms of Alzheimer's Disease -- References -- Chapter 3: Autosomal Dominant Alzheimer's Disease: Underlying Causes -- Introduction -- APP -- PSEN1 -- PSEN2 -- Genetic Testing and Search for Novel AD Genes -- Conclusion -- References -- Chapter 4: Genetic Risk Factors for Alzheimer's Disease -- Early-Onset alzheimer's Disease and Late-Onset alzheimer's Disease: Causative and Susceptibility Genes -- Smaller-Scale Genetic Association Studies: The Candidate Gene Approach -- Apolipoprotein E -- Inconsistent Replication: Meta-analyses in the AlzGene Database -- Larger-Scale Genetic Association Studies: The Genome-Wide Approach -- The HapMap Project and the 1000 Genomes Project -- International Consortia: Meta-analyses of GWAS -- International Genomics of Alzheimer's Project: Mega-meta- analysis of GWAS -- Population Attributable Fraction: Understudied Populations.
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9781447163794
    Additional Edition: Erscheint auch als Druck-Ausgabe 9781447163794
    Language: English
    URL: lizenzpflichtig
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    Online Resource
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    GBV
  • 10
    Online Resource
    Online Resource
    Neurodegenerative Diseases. (2018)
    Cham : Springer
    Details
    UID:
    (DE-627)1673204805
    Format: 1 online resource (412 pages)
    Edition: 2nd ed.
    ISBN: 9783319729381
    Content: Intro -- Contents -- Contributors -- 1: Genetics and Epigenetics in the Neurodegenerative Disorders of the Central Nervous System -- Introduction -- Genetics: Basic Concept -- Types of Genetic Studies -- Genetic Studies Based on Linkage Analysis -- Genetic Study Based on Candidate Genes -- Genome-Wide Association Studies (GWAS) -- NGS Technologies -- Genetic Features of Common Neurodegenerative Diseases -- Progress in AD Genetics -- Progress in PD Genetics -- Progress in FTLD Genetics -- Progress in ALS Genetics -- Epigenetics: Basic Concepts -- Methylation -- ncRNAs -- Chromatin Remodeling -- Technologies Used in Epigenetic Studies -- References -- 2: Diagnosis of Alzheimer's Disease Typical and Atypical Forms -- Introduction -- Clinical Presentation of Typical AD -- Diagnostic Criteria for Typical AD -- The NINCDS-ADRDA Criteria -- Revisions of the NINCDS-ADRDA Criteria -- The International Working Group (IWG-2) Criteria -- NIA-AA Criteria -- DSM-V Criteria -- Atypical Forms of AD -- References -- 3: Genetic Complexity of Early-Onset Alzheimer's Disease -- Introduction -- APP -- PSEN1 -- PSEN2 -- Unexplained Early-Onset AD -- Genetic Testing and Search for Novel AD Genes or Disease Modifiers -- References -- 4: Genetic Risk Factors for Complex Forms of Alzheimer's Disease -- Introduction -- Early Linkage Studies and Candidate Gene Association Studies -- The APOE Gene -- Early Genome-Wide Linkage Analyses -- Candidate Gene Association Studies -- Genome-Wide Association Studies -- Early Small-Scale Genome-Wide Association Studies -- Large-Scale Genome-Wide Association Studies -- Genome-Wide Association Studies in Non-European Populations -- Moving Beyond Conventional Genome-Wide Association Studies -- The Search for Associations with Rare Variants -- The Post-GWAS Era: A New Frontier -- References.
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9783319729374
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783319729374
    Language: English
    URL: lizenzpflichtig
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    BSZ
    GBV
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