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  • 1
    UID:
    (DE-627)560330332
    Format: 20 Bl.
    Note: Göttingen, Univ., Habil.-Schr., 2005
    Language: German
    Keywords: Hochschulschrift
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  • 2
    UID:
    (DE-627)494633387
    Format: Getr. Zählung
    Edition: Kumulatives Verfahren
    Note: Göttingen, Univ., Habil.-Schr., 2005
    Language: German
    Keywords: Hochschulschrift
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  • 3
    UID:
    (DE-627)83595126X
    Format: Online-Ressource (vii, 224 pages) , color illustrations
    Edition: Online-Ausg.
    ISBN: 9783319202914 , 331920291X
    Series Statement: Recent results in cancer research volume 200
    Content: This issue of Recent Results in Cancer Researchpresents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
    Note: Description based upon print version of record , Preface; Contents; 1 DNA Repair and Chromosomal Translocations; Abstract; 1Introduction; 2Genome Stability; 3DNA Damage and Repair; 3.1 Balance of DNA Damage and DNA Repair; 3.2 Sources of DNA Damage; 3.3 Types of DNA Damage and Their Source; 3.3.1 Uracil, Abasic Sites, 8-Oxoguanine, Single Strand Breaks, Pyrimidine Dimers, O-6-Methylguanine; 3.3.2 Replication Errors and Mismatches; 3.3.3 Double Strand Breaks (DSBs); Random DSBs Due to External Influences; Random DSBs Due to Internal Influences; Directed DSBs Due to Internal Processes (e.g., Immunoglobulin Rearrangements) , RAG 1/2 Associated DSBsAID Associated DSBs; DSB Due to Normal Chromatin Movement and Processes (Topoisomerase and Helicase Action); 3.4 Detecting DNA Damage; 3.4.1 Detecting DSB and Signaling for Repair; Poly(ADP-ribosyl)ation; Gamma H2AX (Phosphorylated Form of H2AX); TP53; 53BP1; 3.4.2 Signaling During Repair; 3.5 Repairing DNA Damage; 3.5.1 Base Excision Repair (BER); 3.5.2 Nucleotide Excision Repair (NER); 3.5.3 Direct Reversal; 3.5.4 Mismatch Repair; 3.5.5 Double Strand Break Repair; Homologous Recombination (HR); Single Strand Annealing (SSA) , BIR (Breakage Induced Replication Template Switching)Classical Non-Homologous End Joining (C-NHEJ); Alternative End Joining Pathway (A-EJ) or Microhomology-Mediated End-Joining (MMEJ); 4Translocations; 4.1 Translocations---the Tip of the Iceberg; 4.2 DSBs and the Resulting Chromosomal Rearrangements; 4.2.1 Consequences of Two DSBs; 4.2.2 Consequences of Three and More DSBs; 4.3 Steric Constraints on the Formation of Chromosomal Rearrangements; 4.3.1 Arrangement and Mobility of Chromosomes in the Interphase Nucleus (Chromosome Territories); 4.4 Functional Consequences of Translocations , 4.4.1 Passenger Translocations4.4.2 Driver Translocations; Fusion Genes; Deregulated Gene Expression; Additional Mechanisms: Disrupting Tumor Suppressor Genes, Two Reciprocal Fusion Proteins; 4.5 Specific Mechanisms Causing Chromosomal Translocations; 4.5.1 Random DsDNA Breaks Followed by Faulty Repair via HR, NHEJ or A-EJ (MMEJ); 4.5.2 Due to Faulty RAG1-2 or AID Action; 4.5.3 Chromothripsis; 4.5.4 Shortened Telomeres; 4.5.5 Template Switching During DNA Replication, Replication Stress; 4.5.6 Increased Rate of Chromosomal Translocations in Certain Mendelian Disorders , 4.6 Why Do We See Certain Translocations Recurringly?4.6.1 Selection Theory; 4.6.2 Factors Influencing the Sites of DSBs and the Efficiency of DSB Repair; Transcriptional Status and Translocation Frequency; Evidence for Regions Targeted by AID Being More Susceptible to Translocations; Evidence for Certain Drugs Causing Certain Translocations; Chromatin Status Plays a Role in DSB Repair; Model Systems to Study Translocations; Evidence for a Defined 3D Arrangement of Interphase Chromosomes?; 4.6.3 Translocations Have to Occur in the Right Cell Type , 4.7 Increased Genomic Instability as a Consequence of Translocations
    Additional Edition: 9783319202907
    Additional Edition: Erscheint auch als Druck-Ausgabe Chromosomal Instability in Cancer Cells
    Language: English
    URL: Volltext  (lizenzpflichtig)
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  • 4
    UID:
    (DE-627)825926610
    Format: Online-Ressource (1 online resource)
    Edition: 3., neu bearbeitete Auflage
    Edition: Online-Ausg.
    Content: Mit aussagekräftigen prä-, intra- und postoperatives Bildern Chirurgen mit langjähriger Berufspraxis vermitteln ihre Erfahrungen und geben Ihnen klare Empfehlungen und übersichtliche Handlungsanweisungen. Sie finden eine umfassende Übersicht zu Krankheitsbildern, Diagnostik, Technik der Basisoperationen und Zugänge, Fehlermöglichkeiten, Maßnahmen bei Komplikationen, medikamentöse Therapieschemata sowie Qualitätssicherung und Rechtsfragen.Aus dem Inhalt:Endokrine ChirurgieGastrointestinale ChirurgieKolorektale ChirurgieHepatobiliäre und Pankreaschirurgie Transplantationschirurgie Techniken der Gefäß- und ThoraxchirurgieDas auf zwei Bände angelegte Werk bietet dem erfahrenen und dem in der Facharztausbildung stehenden chirurgisch tätigen Arzt das gesamte Wissen auf dem aktuellen Stand.Allgemein- und Viszeralchirurgie I - Allgemeinchirurgie Common Trunk, 3. Aufl. 2014ISBN 978-3-437-24705-7Die Inhalte dieses Titels sind auch im Online-Produkt OP-Welt.de. Diese und allen anderen Medizinwelten finden Sie auf www.Elsevier-Medizinwelten.de.Von dort haben Sie Zugriff auf weitere Informationen zu den Produkten, können sich einen kostenfreien Testzugang einrichten oder 'Ihre Welt' direkt kaufen.
    Note: Includes bibliographical references , Haupttitel; Inhaltsverzeichnis; Impressum; Vorwort zur 3. Auflage; Aus dem Vorwort zur 1. Auflage; Autorenverzeichnis; Nachruf auf Professor Dr. Heinz Becker; Mitherausgeber der 1. und 2. Auflage; I. Endokrine Chirurgie; Kapitel 1. Schilddrüse; A Gutartige Erkrankungen; 1.2. Diagnostik; 1.3. Indikation zur Operation; 1.4. Operation; 1.5. Komplikationen; 1.6. Nachbehandlung, Rezidivprophylaxe; B Schilddrüsenkarzinom; 1.8. Diagnostik; 1.9. Operative Therapie; 1.10. Rezidiveingriff; 1.11. Therapie von Fernmetastasen; 1.12. Komplikationen; 1.13. Postoperative Therapie; 1.14. Tumornachsorge , 1.15. PrognoseKapitel 2. Nebenschilddrüse; 2.1. Vorbemerkungen; 2.2. Primärer Hyperparathyreoidismus; 2.3. Sekundärer Hyperparathyreoidismus; Kapitel 3. Nebenniere; 3.1. Historische Vorbemerkungen; 3.2. Anatomie und Physiologie der Nebenniere; 3.3. Physiologie Nebennierenrinde (NNR); 3.4. Diagnostik - Indikation; 3.5. Operative Therapie; 3.6. Spezielle Operationstechnik; 3.7. Therapie des malignen Nebennierentumors; 3.8. Nebennierentumoren in der Schwangerschaft; 3.9. Prognose; 3.10. Nachsorge; Kapitel 4. Neuroendokrine Tumoren; A Neuroendokrine Neoplasien - allgemeine Gesichtspunkte , 4.2. Epidemiologie und Häufigkeitsverteilung4.3. Pathohistologie; 4.4. Diagnostik; 4.5. Operative Therapie; 4.6. Nichtoperative Therapie; B Neuroendokrine Neoplasien - organspezifische Gesichtspunkte; 4.8. Neuroendokrine Neoplasien des Magens; 4.9. Neuroendokrine Neoplasien des Pankreas; 4.10. NEN des Dünndarms, der Appendix, des Dickdarms plus Rektum; II. Gastrointestinale Chirurgie; Kapitel 5. Chirurgische Onkologie; 5.1. Einleitung; 5.2. Tumorbiologie und Genetik; 5.3. Tumormetastasierung; 5.4. Tumormarker; 5.5. Stadieneinteilung; 5.6. Diagnostik und Staging , 5.7. Prinzipien der chirurgischen TherapieKapitel 6. Ösophagus; 6.1. Einleitung; 6.2. Divertikel; 6.3. Funktionsstörungen; 6.4. Ösophagusverletzungen; 6.5. Benigne Tumoren; 6.6. Ösophaguskarzinom; Kapitel 7. Zwerchfell und Reflux; 7.1. Zwerchfellhernien; 7.2. Hiatushernien; 7.3. Refluxkrankheit; 7.4. Diagnostik; 7.5. Konservative Therapie und Operationsindikation; 7.6. Operative Therapie; 7.7. Postoperative Behandlung; Kapitel 8. Magen - Duodenum; A Gutartige Erkrankungen; 8.2. Diagnostik; 8.3. Therapie des Ulcus ventriculi und duodeni; 8.4. Allgemeine Aspekte der operativen Therapie , 8.5. Operationsvorbereitung8.6. Spezielle operative Techniken und Verfahren; 8.7. Operationen bei akuten Ulkuskomplikationen; 8.8. Minimalinvasives laparoskopisches Vorgehen; 8.9. Komplikationen; 8.10. Krankheiten des operierten Magens; 8.11. Postoperative Behandlung - Nachsorge; B Magenkarzinom; 8.13. Pathogenese; 8.14. Klassifikation und Tumor-Staging; 8.15. (Chirurgische) Anatomie des Magens; 8.16. Tumorlokalisation - Tumorwachstum - Metastasierung; 8.17. Diagnostik - klinische Symptome; 8.18. Operationsindikation; 8.19. Operative Therapie; 8.20. Prognose - Prognosefaktoren , 8.21. Schlussbetrachtungen und Ausblick
    Additional Edition: 3437169661
    Additional Edition: 9783437248115
    Additional Edition: 9783437169663
    Additional Edition: Erscheint auch als Druck-Ausgabe Allgemein- und Viszeralchirurgie ; 2: Spezielle operative Techniken München : Elsevier, Urban & Fischer, 2015 3437248111
    Additional Edition: 9783437248115
    Language: German
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  • 5
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    UID:
    (DE-627)1654280003
    Format: Online-Ressource (VII, 224 p. 39 illus. in color, online resource)
    Edition: 1st ed. 2015
    ISBN: 9783319202914
    Series Statement: Recent Results in Cancer Research 200
    Content: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification
    Note: Includes bibliographical references at the end of each chapters , DNA Repair and Chromosomal TranslocationsCINcere modelling: What have mouse models for chromosome instability taught us? -- Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development -- Consequences of aneuploidy in cancer: transcriptome and beyond.
    Additional Edition: 9783319202907
    Additional Edition: Erscheint auch als Druck-Ausgabe Chromosomal instability in cancer cells Cham : Springer, 2015 9783319202907
    Language: English
    Subjects: Biology
    RVK:
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 6
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    UID:
    (DE-605)HT030026655
    Format: 1 Online-Ressource (VII, 224 p. 39 illus. in color)
    Edition: 1st ed. 2015
    ISBN: 9783319202914
    Series Statement: Recent Results in Cancer Research 200
    Additional Edition: Printed edition 9783319202907
    Additional Edition: Printed edition 9783319202921
    Additional Edition: Printed edition 9783319349626
    Language: English
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  • 7
    UID:
    (DE-101)1063736617
    Format: XII, 584 S. , Ill., graph. Darst.
    Edition: 3., neu bearb. Aufl.
    ISBN: 9783437248023 (Set) , 9783437248115 , 3437248111
    Language: German
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  • 8
    Online Resource
    Online Resource
    Cham : Springer International Publishing | Cham : Springer International Publishing AG
    UID:
    (DE-603)368089797
    Format: 1 Online-Ressource (VII, 224 Seiten) , 39 illus. in color.
    Edition: 1st ed. 2015
    ISBN: 9783319202914 , 331920291X
    Series Statement: Recent Results in Cancer Research 200
    Additional Edition: Erscheint auch als Druck-Ausgabe Chromosomal Instability in Cancer Cells Cham : Springer International Publishing, 2015 9783319202907
    Additional Edition: 9783319202907
    Additional Edition: 9783319202921
    Additional Edition: 9783319349626
    Language: English
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  • 9
    UID:
    (DE-604)BV044390045
    Format: 1 online resource
    Edition: 3., neu bearbeitete Auflage
    ISBN: 9783437169663 , 3437169661 , 9783437248115
    Note: Includes bibliographical references
    Additional Edition: Erscheint auch als Druck-Ausgabe Rintelen, Henriette Allgemein- und Viszeralchirurgie II - Spezielle operative Techniken : Elsevier Health Sciences Germany,c2015 ISBN 9783437248115
    Language: German
    Keywords: Aufsatzsammlung
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 10
    Online Resource
    Online Resource
    Cham : Springer International Publishing
    UID:
    (DE-604)BV046816298
    Format: 1 Online Ressource (VII, 224 Seiten, 39 Illustrationen in Farbe)
    Edition: 1st ed. 2015
    ISBN: 9783319202914
    Series Statement: Recent Results in Cancer Research
    Content: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification
    Note: DNA Repair and Chromosomal Translocations -- CINcere modelling: What have mouse models for chromosome instability taught us? -- Telomere Dysfunction, Chromosomal Instability and Cancer -- Genetic Instability and Disease Prognostication -- Causes of Chromosomal Instability -- Patterns of Chromosomal Aberrations in Solid Tumors -- Yeast as Models of Mitotic Fidelity -- The diverse effects of complex chromosome rearrangements and chromothripsis in cancer development -- Consequences of aneuploidy in cancer: transcriptome and beyond
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783319202907
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783319202921
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9783319349626
    Language: English
    Subjects: Biology
    RVK:
    URL: Volltext  (URL des Erstveröffentlichers)
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