Format:
21
ISSN:
1546-1718
Content:
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P 〈 5 × 10−8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.
Note:
Gesehen am 15.08.2023
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Published: 31 May 2021
In:
Nature genetics, London : Macmillan Publishers Limited, part of Springer Nature, 1992, 53(2021), 6 vom: Juni, Seite 840-860, 1546-1718
In:
volume:53
In:
year:2021
In:
number:6
In:
month:06
In:
pages:840-860
In:
extent:21
Language:
English
DOI:
10.1038/s41588-021-00852-9
URL:
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