Format:
Online-Ressource
ISSN:
0974-7826
Content:
Abstract: Objectives���Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-��) are proinflammatory cytokines that play a major role in tumorigenesis. These biomarkers are relatively unexplored in gallbladder cancer (GBC) for their diagnostic and prognostic utility. Material and Methods���A total of 40 healthy controls and 40 GBC patients were recruited. Serum IL-6 and TNF-�� levels were measured, and their diagnostic utility was analyzed using the receiver operating characteristics (ROC) curve. The relationship between clinicopathological variables and serum tumor markers (CEA, CA125, and CA19-9) in identifying GBC patients was also assessed. Results���Serum IL-6 and TNF-�� expression were significantly higher in the GBC group (for both IL-6 and TNF-��, p���=���0.0001) than in healthy controls. ROC analysis revealed that the areas under the curve for serum IL-6 and TNF-�� were 0.89 and 0.71, respectively. The sensitivity and specificity for serum IL-6 were 82.5 and 97.5%, respectively, at an optimal cutoff value of 10.34 pg/mL; for TNF-��, they were 40.0 and 100%, respectively, at a cutoff value of 0.24 pg/mL. There was also a significant difference in serum IL-6 levels between the resectable and nonresectable GBC groups. Serum IL-6 showed a positive correlation with CA125 (r���=���0.34, p���〈���0.05), while no correlation was observed between serum TNF-�� and serum tumor markers (CEA, CA125, and CA19-9). Conclusion���Serum IL-6 may serve as a diagnostic marker and a predictor of resectability, and it can be used in conjunction with other serum tumor markers in GBC.
In:
day:24
In:
month:08
In:
year:2023
In:
Journal of laboratory physicians, Mumbai : Medknow Publ., 2009-, (24.08.2023), 0974-7826
Language:
English
DOI:
10.1055/s-0043-1772772
URN:
urn:nbn:de:101:1-2023101210125099076727
URL:
https://doi.org/10.1055/s-0043-1772772
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023101210125099076727
URL:
https://d-nb.info/1305814622/34
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