Format:
Online-Ressource
,
Begleitmaterial
ISSN:
2699-4445
Content:
Abstract: Pleomorphic xanthoastrocytoma (PXA) poses a diagnostic challenge. The present study relies on methylation-based predictions and focuses on copy number variations (CNV) in PXA. We identified 551 tumors from patients having received the histologic diagnosis or differential diagnosis pleomorphic xanthoastrocytoma (PXA) uploaded to the web page www.molecularneuropathology.org. Of these 551 tumors, 165 received the prediction “methylation class (anaplastic) pleomorphic xanthoastrocytoma” with a calibrated score 〉=0.9 by the brain tumor classifier version v12.8 and, therefore, were defined the PXA reference set designated mcPXAref. In addition to these 165 mcPXAref, 767 other tumors received the prediction mcPXA with a calibrated score 〉=0.9 but without a histological PXA diagnosis. The total number of individual tumors predicted by histology and/or by methylome based classification as PXA, mcPXA or both was 1318, and these were designated the study cohort. The selection of a control coh.... https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/5156
In:
volume:4
In:
year:2023
In:
Free Neuropathology, Muenster : Prof. Dr. Werner Paulus, University of Muenster, Institute of Neuropathology, [2020]-, 4 (2023), 2699-4445
Language:
English
DOI:
10.17879/freeneuropathology-2023-5156
URN:
urn:nbn:de:hbz:6:3-freeneuropathology-2023-53105
URL:
https://doi.org/10.17879/freeneuropathology-2023-5156
URL:
https://nbn-resolving.org/urn:nbn:de:hbz:6:3-freeneuropathology-2023-53105
URL:
https://d-nb.info/1314959492/34
URL:
https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/5156/5310
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