Format:
Online-Ressource
ISSN:
1437-4315
Content:
Abstract: Mitochondria are surrounded by the two membranes, the outer and inner membranes, whose lipid compositions are optimized for proper functions and structural organizations of mitochondria. Although a part of mitochondrial lipids including their characteristic lipids, phosphatidylethanolamine and cardiolipin, are synthesized within mitochondria, their precursor lipids and other lipids are transported from other organelles, mainly the ER. Mitochondrially synthesized lipids are re-distributed within mitochondria and to other organelles, as well. Recent studies pointed to the important roles of inter-organelle contact sites in lipid trafficking between different organelle membranes. Identification of Ups/PRELI proteins as lipid transfer proteins shuttling between the mitochondrial outer and inner membranes established a part of the molecular and structural basis of the still elusive intra-mitochondrial lipid trafficking.
In:
volume:401
In:
number:6-7
In:
year:2020
In:
pages:821-833
In:
extent:13
In:
Biological chemistry, Berlin [u.a.] : de Gruyter, 1996-, 401, Heft 6-7 (2020), 821-833 (gesamt 13), 1437-4315
Language:
English
DOI:
10.1515/hsz-2020-0121
URN:
urn:nbn:de:101:1-2408061711525.664786555834
URL:
https://doi.org/10.1515/hsz-2020-0121
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2408061711525.664786555834
URL:
https://d-nb.info/1338081411/34
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