X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
Type of Material
Type of Publication
Consortium
Language
  • 1
    Online Resource
    Online Resource
    Screen of Compounds to Target Tumor Cells with Chromothripsis (2021)
    [Erscheinungsort nicht ermittelbar] : [Verlag nicht ermittelbar]
    Details
    UID:
    (DE-627)1828047988
    Content: Chromothripsis is a form of genomic instability that begins with a shattering event leading to clustered chromosomal aberrations. Chromothriptic cells acquire multiple genomic alterations in confined genomic regions restricted to one or a few chromosomes. Due to the very high prevalence of chromothripsis in different types of cancers especially Sonic Hedgehog medulloblastomas, osteosarcomas and neuroblastomas and due to the link between chromothripsis and poor prognosis for cancer patients, finding therapeutic options to specifically target tumor cells with chromothripsis is highly relevant. Chromothripsis is linked to homologous recombination (HR) repair deficiency in a number of tumor types. Therefore, synthetic lethality may potentially be used, whereby HR repair deficiencies of cancer cells are exploited by applying a PARP inhibitor, which spares repair-proficient normal cells. In the primary screen, I searched for potential additive or synergistic partners of a PARP inhibitor (BGB290) and also searched for drugs that are potent as single agents. The analysis of the primary screen done in 15 cell lines identified romidepsin and nanaomycin A as promising candidates to eliminate tumor cells with chromothripsis. To confirm the potential additivity or synergism of these drugs with the PARP inhibitor, a secondary screen was done where drugs were titrated against each other in 8×8 matrix settings. The secondary screen revealed a strong synergistic interaction between BGB290 and romidepsin in chromothriptic Sonic Hedgehog (SHH) medulloblastoma patient derived xenograft spheroid models but antagonism in non-chromothriptic control cells. Functional assays revealed that the synergistic effect between BGB290 and romidepsin was not TP53 dependent. Romidepsin and BGB290 combination treatment caused G2 cell cycle arrest and apoptosis in chromothriptic DAOY cells. The mitotic rate was decreased by romidepsin and BGB290 combination treatment in DAOY cells as shown by acetyl-αtubulin and phospho-histone H3 immunostaining. Gene expression analysis revealed that the romidepsin and BGB290 combination treatment was associated to the regulation of MYC target genes. To further analyze the link between MYC expression and the effects of the combination treatment, I used an inducible MYC ON / OFF system. When MYC was overexpressed, romidepsin and BGB290 showed additivity, while in the MYC OFF state the additive effect was replaced by antagonism. This indicates that MYC overexpression plays a role in the interaction between BGB290 and romidepsin. Lastly, the in vivo efficacy of BGB290 and romidepsin combination treatment was confirmed in patient-derived xenograft mouse models.
    Note: Dissertation 2021
    Language: English
    URL: kostenfrei
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Fulltext
    BSZ
    GBV
  • 2
    Online Resource
    Online Resource
    Screen of compounds to target tumor cells with chromothripsis (22)
    Heidelberg
    Details
    UID:
    (DE-627)1778258522
    Format: 1 Online-Ressource (273 Seiten) , Illustrationen, Diagramme
    Note: Dissertation Ruperto-Carola University of Heidelberg 2021 , Zusammenfassungen in deutscher und englischer Sprache
    Additional Edition: Erscheint auch als Druck-Ausgabe Khalid, Umar, 1991 - Screen of compounds to target tumor cells with chromothripsis Heidelberg, 2021
    Language: English
    Keywords: Hochschulschrift
    DOI: 10.11588/heidok.00029959
    URN: urn:nbn:de:bsz:16-heidok-299596
    URL: kostenfrei
    URL: kostenfrei
    URL: Volltext  (kostenfrei)
    URL: https://nbn-resolving.org/urn:nbn:de:bsz:16-heidok-299596
    URL: https://d-nb.info/1246270773/34
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Fulltext
    BSZ
    GBV
  • 3
    Online Resource
    Online Resource
    Screen of Compounds to Target Tumor Cells with Chromothripsis (2021)
    Heidelberg : Universitätsbibliothek Heidelberg
    Details
    UID:
    (DE-603)48874279X
    Format: 1 Online-Ressource
    Note: Dissertation Heidelberg, Universität Heidelberg 2021
    Language: English
    Keywords: Hochschulschrift
    DOI: 10.11588/heidok.00029959
    URN: urn:nbn:de:bsz:16-heidok-299596
    URL: https://doi.org/10.11588/heidok.00029959
    URL: https://nbn-resolving.org/urn:nbn:de:bsz:16-heidok-299596
    URL: kostenfrei
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    HeBIS
  • 4
    Online Resource
    Online Resource
    Does work-life balance moderate the relationship between career commitment and career success? : evidence from an emerging Asian economy (2020)
    Show associated volumes
    Details
    UID:
    (DE-627)1745886230
    ISSN: 2076-3387
    Content: This study examines the relationship between career commitment and employee career success (objective and subjective success) in middle-level employees working in the service sector. Further, the study investigates the moderating effect of work-life balance on the relationship between career commitment and career success. By analyzing data from 360 middle level working employees, our empirical results show that career commitment has a positive and significant effect on the objective and subjective career success of employees. Work-life balance positively moderates the relationship between career commitment and subjective career success, whereas it fails to moderate the relationship between career commitment and objective career success. The study contributes by providing a better understanding of the employee’s perception of career commitment and career success and their management in emerging markets. Avenues for future research are identified.
    In: Administrative Sciences, Basel : MDPI, 2011, 10(2020), 4/82 vom: Dez., Seite 1-12, 2076-3387
    In: volume:10
    In: year:2020
    In: number:4/82
    In: month:12
    In: pages:1-12
    Language: English
    Keywords: Aufsatz in Zeitschrift
    DOI: 10.3390/admsci10040082
    URL: kostenfrei
    URL: kostenfrei
    URL: kostenfrei
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Open Access Request
    BSZ
    GBV
  • 5
    Online Resource
    Online Resource
    An Exploratory Analysis of Islamic Finance Products for Housing Finance in the UK Market (2018)
    [S.l.] : SSRN
    Details
    UID:
    (DE-627)1790955157
    Format: 1 Online-Ressource (19 p)
    Content: Purpose – The purpose of this paper is to provide an exploratory analysis Islamic finance products for housing finance in the UK market and make a comparative study of all available products in the market in order for drawing out the best product presented. To this end, the study examines the key Sharī'ah compliant products offered by different Islamic financial service providers for home financing in the UK and finds as to which product offers the best value for money among its competitors. Design/methodology/approach – The study reviews the various methods available and attempts to justify their use for both parts of the study, part 1 of which deals with the methods used for the review of the key principles of Islamic banking and the surrounding subject area, while the other part discusses the variables and approaches used for the cross-product analysis. The research method adopted is qualitative in nature using first and secondary data. The research of first part of the study is qualitative and is conducted through a literature review. The second part of the study involved collecting primary data with regards to the Islamic housing finance market in the UK. Findings – The research finds that if a prospective applicant for an Islamic housing finance does not have sufficient savings for a high deposit and accepts the Sharī'ah compliance products of Islamic home financing providers in the UK, then the Ahli United Manzil Home purchase programme is the most suitable and competitive; although highest application fees incur. Otherwise the applicant will have to wait until the Sharī'ah compliance products have been thoroughly established. Practical implications – The study recommends that an independent Sharī'ah advisory Board be set up in order to confirm and analyse the Sharī'ah issues pertaining to Islamic home financing, in an objective manner. Originality/value – The paper provides (so far as the authors are aware) the first cross-product analysis of the products offered by Islamic housing finance providers in the UK with the aim of showing the best home financing mode in terms of cost and also the product that complies most with the Sharī'ah
    Note: In: International Journal of Excellence in Islamic Banking & Finance, 2014 , Nach Informationen von SSRN wurde die ursprüngliche Fassung des Dokuments June 6, 2014 erstellt
    Language: English
    URL: kostenfrei
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    BSZ
    GBV
  • 6
    Online Resource
    Online Resource
    Ādalīs (2) : riwāyah = Adalis (2020)
    ʻAmmān : al-Manhal lil-Nashr al-Iliktirūnī
    Details
    UID:
    (DE-603)517778793
    Format: 1 Online-Ressource (158 pages)
    Edition: al-Ṭabʻah al-iliktirūnīyah al-ūlá
    Original writing edition: الطبعة الإلكترونية الأولى
    Original writing title: آدليس (2) : رواية
    Original writing person/organisation: عودة, عمر خالد،
    Original writing publisher: عمان : المنهل للنشر الإلكتروني،
    Note: Electronic reproduction from the print version by Al Manhal
    Additional Edition: Erscheint auch als Druck-Ausgabe ʻAwdah, ʻUmar Khālid Ādalīs (2) : riwāyah = Adalis al-Jīzah : Nūn lil-Nashr wa-al-Tawzīʻ, [2018] 9789777781565
    Additional Edition: 9789777781565
    Language: Arabic
    URL: http://platform.almanhal.com/MNHL/Preview/?ID=1-133316
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    HeBIS
  • 7
    Online Resource
    Online Resource
    Ādalīs (2) : riwāyah = Adalis (2020)
    ʻAmmān : al-Manhal lil-Nashr al-Iliktirūnī
    Details
    UID:
    (DE-627)1852645695
    Format: 1 Online-Ressource (158 pages)
    Edition: al-Ṭabʻah al-iliktirūnīyah al-ūlá
    Original writing edition: الطبعة الإلكترونية الأولى
    Original writing title: آدليس (2) : رواية
    Original writing person/organisation: عودة, عمر خالد،
    Original writing publisher: عمان : المنهل للنشر الإلكتروني،
    Note: Electronic reproduction from the print version by Al Manhal
    Additional Edition: Erscheint auch als Druck-Ausgabe ʻAwdah, ʻUmar Khālid Ādalīs (2) : riwāyah = Adalis al-Jīzah : Nūn lil-Nashr wa-al-Tawzīʻ, [2018] 9789777781565
    Language: Arabic
    URL: Deutschlandweit zugänglich
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Stabi Berlin
    UB Potsdam
    BSZ
    GBV
  • 8
    Online Resource
    Online Resource
    Ādalīs (2) : riwāyah = Adalis (2020)
    ʻAmmān : al-Manhal lil-Nashr al-Iliktirūnī
    Details
    UID:
    (DE-602)gbv_1852645695
    Format: 1 Online-Ressource (158 pages)
    Edition: al-Ṭabʻah al-iliktirūnīyah al-ūlá
    Original writing edition: الطبعة الإلكترونية الأولى
    Original writing title: آدليس (2) : رواية
    Original writing person/organisation: عودة, عمر خالد،
    Original writing publisher: عمان : المنهل للنشر الإلكتروني،
    Note: Electronic reproduction from the print version by Al Manhal
    Additional Edition: Erscheint auch als Druck-Ausgabe ʻAwdah, ʻUmar Khālid Ādalīs (2) : riwāyah = Adalis al-Jīzah : Nūn lil-Nashr wa-al-Tawzīʻ, [2018] ISBN 9789777781565
    Language: Arabic
    URL: Deutschlandweit zugänglich
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Stabi Berlin
    UB Potsdam
    KOBV
  • 9
    Article
    Article
    "Transformation accommodation": towards the convergence of Sharī ̒ah and common law in Muslim minority jurisdictions (2016)
    Show associated volumes
    Details
    UID:
    (DE-627)1637149212
    ISSN: 0268-0556
    In: Arab law quarterly, Leiden [u.a.] : Brill, 1985, 30(2016), 3, Seite 245-261, 0268-0556
    In: volume:30
    In: year:2016
    In: number:3
    In: pages:245-261
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Article
    BSZ
  • 10
    Online Resource
    Online Resource
    Vision Based Robot Navigation : Obstacle Avoidance & Road Following Behaviors (2013)
    Saarbrücken : LAP LAMBERT Academic Publishing
    Details
    UID:
    (DE-101)1031865160
    Format: Online-Ressource
    Edition: 1. Aufl.
    ISBN: 9783659321580 , 3659321583
    Note: Lizenzpflichtig. - Vom Verlag als Druckwerk on demand angeboten
    Language: English
    URN: urn:nbn:de:101:1-2013030214793
    URL: https://nbn-resolving.org/urn:nbn:de:101:1-2013030214793
    URL: https://d-nb.info/1031865160/34
    URL: https://www.lap-publishing.com
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    DNB
Nothing or not found what you are looking for? Please check your search query. For a search / Interlibrary loan from abroad use the search set "KOBV International" in the old KOBV portal.
Close ⊗
This website uses cookies and the analysis tool Matomo. Further information can be found on the KOBV privacy pages