Format:
12
,
Illustrationen
ISSN:
1878-4046
Content:
Rationale and Objectives: To investigate the diagnostic value of radiomics features and dual-source dual-energy CT (DECT) based material decomposition in differentiating low-risk thymomas, high-risk thymomas, and thymic carcinomas.Materials and Methods: This retrospective study included 32 patients (16 males, mean age 66 +/- 14 years) with pathologically confirmed thymic masses who underwent contrast-enhanced DECT between 10/2014 and 01/2023. Two experienced readers evaluated all patients regarding conventional radiomics features, as well as DECT-based features, including attenuation (HU), iodine density (mg/mL), and fat fraction (%). Data comparisons were performed using analysis of variance and chi-square statistic tests. Receiver operating character-istic curve analysis and Cox-regression tests were used to discriminate between low-risk/high-risk thymomas and thymic carcinomas.Results: Of the 32 thymic tumors, 12 (38%) were low-risk thymomas, 11 (34%) were high-risk thymomas, and 9 (28%) were thymic carcinomas. Values differed significantly between low-risk thymoma, high-risk thymoma, and thymic carcinoma regarding DECT-based features (p 〈= 0.023) and 30 radiomics features (p 〈= 0.037). The area under the curve to differentiate between low-risk/high-risk thymomas and thymic cancer was 0.998 (95% CI, 0.915-1.000; p 〈 0.001) for the combination of DECT imaging parameters and radiomics features, yielding a sensitivity of 100% and specificity of 96%. During a follow-up of 60 months (IQR, 35-60 months), the multiparametric approach including radiomics features, DECT parameters, and clinical parameters showed an excellent prognostic power to predict all-cause mortality (c-index = 0.978 [95% CI, 0.958-0.998], p = 0.003).Conclusion: A multiparametric approach including conventional radiomics features and DECT-based features facilitates accurate, non-invasive discrimination between low-risk/high-risk thymomas and thymic carcinomas.
Note:
Online verfügbar: 25. April 2023, Artikelversion: 27. November 2023
,
Gesehen am 20.02.2024
In:
Academic radiology, Philadelphia, PA [u.a.] : Elsevier, 1994, 30(2023), 12 vom: Dez., Seite 3010-3021, 1878-4046
In:
volume:30
In:
year:2023
In:
number:12
In:
month:12
In:
pages:3010-3021
In:
extent:12
Language:
English
DOI:
10.1016/j.acra.2023.03.034
URL:
Volltext
(lizenzpflichtig)
URL:
Volltext
(lizenzpflichtig)
Bookmarklink