Format:
Online-Ressource
ISSN:
1439-2054
Content:
Abstract: The pursuit of effective therapeutic strategies for tissue damage has prompted extensive scholarly investigations worldwide. Tissue engineering has emerged as a prominent approach, particularly through the utilization of artificial scaffolds that closely resemble the natural extracellular matrix (ECM). These scaffolds exhibit multi‐scale topological structures and surface physicochemical properties, which significantly influence cellular behavior, thereby attracting considerable attention from numerous researchers. This comprehensive review is concentrated on the primary techniques employed in the fabrication of biodegradable polymer scaffolds possessing oriented porous structures, and the most recent advancements in tissue engineering research are presented. Significantly, the profound influence of scaffold surface characteristics is underscored on cellular behavior, elucidating the superiority of oriented pore structures over disordered ones in mimicking the distinctive attributes of the ECM. Enhanced cell adhesion, proliferation, and tissue differentiation represent notable advantages associated with oriented porous scaffolds. Additionally, the critical interplay between scaffold structure, performance, and functionalization is emphasized, highlighting the imperative to optimize the clinical application of tissue engineering scaffolds.
In:
day:15
In:
month:10
In:
year:2023
In:
extent:20
In:
Macromolecular materials and engineering, Weinheim : Wiley-VCH GmbH, [2000]-, (15.10.2023) (gesamt 20), 1439-2054
Language:
English
DOI:
10.1002/mame.202300246
URN:
urn:nbn:de:101:1-2023101615180595413238
URL:
https://doi.org/10.1002/mame.202300246
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023101615180595413238
URL:
https://d-nb.info/1306223784/34
URL:
https://doi.org/10.1002/mame.202300246
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