UID:
(DE-602)gbv_1651864217
Format:
Online-Ressource (XII, 203 p. 52 illus., 34 illus. in color, digital)
ISBN:
9781461440093
,
1283623625
,
9781283623629
Series Statement:
SpringerLink
Content:
Systems Biology of Apoptosis summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches. Systems biology combines rigorous mathematical modelling with experimental approaches in a closed loop cycle for advancing our knowledge about complex biological processes. In this book, the editor describes the contemporary systems biology studies devoted to apoptotic signaling and focuses on the question how systems biology helps to understand life/death decisions made in the cell and to develop new approaches to rational treatment strategies.
Note:
Description based upon print version of record
,
Systems Biologyof Apoptosis; Preface; Contents; Contributors; Chapter 1: Modeling Formalisms in Systems Biology of Apoptosis; 1.1 Why Modeling Apoptosis?; 1.2 Overview of Mathematical Formalisms; 1.2.1 Linear Regression Models; 1.2.2 Boolean Models; 1.2.3 Quantitative Modeling Approaches; 1.3 Basic Concepts in ODE Modeling; 1.3.1 Building Blocks of Biochemical Models; 1.3.2 Simulation; 1.3.3 Parameter Estimation, Identifiability, and Model Selection; 1.3.4 Sensitivity Analysis; 1.4 Conceptual Model of an Irreversible Switch in Apoptosis
,
1.5 Mechanistic ODE Models Describing Apoptosis Networks1.5.1 Origins of a Robust All-or-None Behavior: Models Characterized by Bistability and Feedback Mechanisms; 1.5.1.1 Extrinsic Apoptosis Pathway; 1.5.1.2 Intrinsic Apoptosis Pathway; 1.5.1.3 Implicit Feedback Mechanisms in the Intrinsic Apoptosis Pathway; 1.5.2 Origins of a Robust All-or-None Behavior: Switching and Threshold Mechanisms Other Than Bistability; 1.5.3 Models Characterized by a Timing Switch; 1.5.4 Ambiguity of Cell Death or Survival; 1.5.5 Understanding Cell-to-Cell Variability; 1.6 Conclusions; References
,
Chapter 2: Systems Biology of Death Receptor-Induced Apoptosis2.1 Death Receptor-Mediated Apoptosis; 2.2 Effectors and Regulators of Extrinsic Apoptosis; 2.2.1 Caspases as Major Effector Molecules of Apoptosis Pathway; 2.2.1.1 Caspase-8/10 Activation at the DISC; 2.2.2 c-FLIP Proteins Regulate Caspase Activation at the DISC; 2.2.3 IAP Family of Proteins; 2.2.4 Bcl-2 Family of Proteins; 2.3 CD95-Induced Nonapoptotic Pathways; 2.3.1 CD95-Mediated NF-kappaB Activation; 2.3.2 The Function of RIP in CD95-Mediated Nonapoptotic Pathways
,
2.4 Mathematical Formalisms Used in Modeling of the Extrinsic Pathway2.4.1 Modeling Extrinsic Apoptosis; 2.4.1.1 Revealing a Threshold Mechanism in CD95-Induced Apoptosis; 2.4.1.2 The Stoichiometry of the DISC Determines Life and Death at CD95; 2.4.1.3 Dual Function of c-FLIPL in Procaspase-8 Processing and Cell Death; 2.5 Conclusions; References; Chapter 3: Systematic Complexity Reduction of Signaling Models and Application to a CD95 Signaling Model for Apoptosis; 3.1 Introduction; 3.2 Graphical Structuring of ODE Models; 3.2.1 Experimental Noise Model and Error Function
,
3.2.2 Parameter Optimization3.2.3 Choosing Significant Error Function Cutoffs; 3.3 Reduction of Graph-Based Models; 3.3.1 Indirect Model Verification and Rejection; 3.4 Topological Model Analysis; 3.4.1 Controllability; 3.4.2 Observability; 3.4.3 Activity; 3.5 The Reduction Graph Data Structure; 3.6 Search Strategies; 3.7 Basic Search Strategies; 3.8 Hybrid Switching Approach; 3.9 Application Example: Reducing a Model of the CD95 Pathway; References; Chapter 4: Systems Biology of the Mitochondrial Apoptosis Pathway; 4.1 ``Mitochondrial ´´or ``Intrinsic´´ Apoptosis Pathway
,
4.2 Regulators of the Mitochondrial Apoptosis Pathway
Additional Edition:
ISBN 9781461440086
Additional Edition:
Buchausg. u.d.T. Systems biology of apoptosis New York : Springer, 2013 ISBN 9781461440086
Language:
English
Subjects:
Biology
Keywords:
Apoptosis
;
Systembiologie
;
Aufsatzsammlung
DOI:
10.1007/978-1-4614-4009-3
URL:
Volltext
(lizenzpflichtig)
Bookmarklink
