Format:
Online-Ressource
ISSN:
2235-3186
Content:
Introduction: Sarcoidosis is characterized by noncaseating granulomatous inflammation in multiple organs. Renal involvement is rare, and granulomatous interstitial nephritis (GIN) is the predominant histological feature. Renal sarcoidosis (RS) is usually diagnosed by exclusion, combining clinical and histological findings, and often remains misdiagnosed. This retrospective study aimed to describe the characteristics and prognosis of patients with RS in China. Methods: Eighteen patients with RS from a single center were enrolled, of whom 15 had biopsy-proven tubulointerstitial nephritis. Their clinicopathological features and renal outcomes were analyzed to understand this rare disease better. Results: Eighteen patients (14 male/4 female) were included in our study. The median estimated glomerular filtration rate (eGFR) was 30.36 (11.57, 60.14) mL/min/1.73 m2. In 15 patients undergoing a renal biopsy, GIN was the most common pathological phenotype (66.67%). Seventeen patients had follow-up records, with a median follow-up of 24.07 (8.82, 60.90) months. One month after treatment, median eGFR increased significantly from 30.36 (11.57, 60.14) mL/min/1.73 m2 to 58.53 (39.35, 80.65) mL/min/1.73 m2, and proteinuria decreased from 1.10 (0.69, 1.58) g/24 h to 0.68 (0.52, 1.05) g/24 h. No patients relapsed or developed end-stage renal disease. Conclusion: RS is a rare but important cause of tubulointerstitial injury, with a favorable long-term prognosis if properly diagnosed and treated promptly.
In:
volume:147
In:
number:10
In:
year:2023
In:
pages:591-598
In:
extent:8
In:
Nephron, Basel : Karger, 2015-, 147, Heft 10 (2023), 591-598 (gesamt 8), 2235-3186
Language:
English
URN:
urn:nbn:de:101:1-2023101200324368694562
URL:
https://doi.org/10.1159/000530668
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023101200324368694562
URL:
https://d-nb.info/1305743709/34
URL:
https://karger.com/nef/article-pdf/doi/10.1159/000530668/3985699/000530668.pdf
URL:
https://karger.com/doi/10.1159/000530668
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