Format:
Online-Ressource
ISSN:
1421-9964
Content:
Introduction: The objective of this study was to investigate myocardial deformation of left (LV) and right ventricle (RV) using 2-dimensional speckle-tracking echocardiography (2D-STE) in fetuses with and without congenital cytomegalovirus (CMV) infection. Methods: This was a prospective single-center study. Vertical transmission was defined by a positive CMV polymerase chain reaction (PCR) test on the amniotic fluid or on the neonate’s urine. Fetuses were divided into group 1 and group 2 if CMV-PCR was positive or negative, respectively. LV and RV global longitudinal strain (GLS) values were obtained and adjusted for gestational age by calculating Z-scores. Univariate analysis was carried out to compare cardiac indices between group 1 and group 2. Results: Fetuses from group 1 (n = 11) had a significantly lower LV myocardial shortening than those from group 2 (n = 32). GLS was −20.7 ± 5.2% and −26.3 ± 4.1%, respectively (p = 0.001). Similarly, GLS Z-score was lower (0.02 ± 0.72) in group 1 than in group 2 (−0.80 ± 0.59) (p = 0.001). Similarly, RV GLS Z-score was significantly impaired in group 1 compared to group 2 (−0.44 ± 1.03 vs. −1.04 ± 0.71, p = 0.041). Conclusion: Fetuses with congenital CMV showed subclinical biventricular myocardial dysfunction. Further studies are needed to confirm the potential role of 2D-STE in identifying fetuses with congenital CMV at risk of postnatal cardiovascular morbidities.
In:
volume:50
In:
number:6
In:
year:2023
In:
pages:430-437
In:
extent:8
In:
Fetal diagnosis and therapy, Basel : Karger, 1986-, 50, Heft 6 (2023), 430-437 (gesamt 8), 1421-9964
Language:
English
URN:
urn:nbn:de:101:1-2023121323234155437430
URL:
https://doi.org/10.1159/000533280
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023121323234155437430
URL:
https://d-nb.info/131327657X/34
URL:
https://karger.com/fdt/article-pdf/50/6/430/4057438/000533280.pdf
URL:
https://karger.com/doi/10.1159/000533280
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