Format:
1 Online-Ressource (358 p)
ISBN:
9780128035535
Content:
Cover -- Title page -- Copyright page -- Contents -- List of Contributors -- Acknowledgments -- Chapter 1 - Current Trends in Cancer Therapy -- PI3K/AKT pathway -- Idelelasib -- mTOR pathway -- mTOR Inhibitors -- Temsirolimus -- Everolimus -- Mitogen-activated protein kinase (MAPK) pathway -- RAF Inhibitors -- Vemurafenib -- Dabrafenib -- Sorafenib -- MEK Inhibitors -- Trametinib -- Combination of MEK and BRAF inhibitors -- EGFR pathway -- EGFR Tyrosine Kinase Inhibitors -- Gefitinib -- Erlotinib -- Afatinib -- EGFR Monoclonal Antibodies -- Panitumumab -- Cetuximab
Content:
Human epidermal growth factor receptor 2 -- Trastuzumab -- Pertuzumab -- Lapatinib -- Ado Trastuzumab Emtansine -- Anaplastic lymphoma kinase pathway -- Crizotinib -- Ceritinib -- Antiangiogenic agents -- VEGF pathway -- VEGF Monoclonal Antibodies -- Bevacizumab -- Ramucirumab -- VEGF Tyrosine Kinase Inhibitors -- Sunitinib -- Sorafenib -- Pazopanib -- Axitinib -- Vandetinib -- Cabozantinib -- Regorafenib -- Immunotherapy -- Cancer Vaccines -- Sipuleucel-T -- Adoptive T Cell Immunotherapy -- Immune Checkpoint Blockade -- CTLA-4 Inhibition -- Ipilimumab -- PD1/PDL1/PDL2 Inhibition -- Nivolumab
Content:
Pembroluzimab -- Toxicities of Immune Checkpoint Inhibitions -- Monitoring Response in Checkpoint Inhibition -- Combination Therapy -- Future Directions -- Cyclin dependent kinases and their pathways -- Palbociclib -- Poly ADP ribose polymerase inhibition -- Olaparib -- Conclusions -- References -- Chapter 2 - Molecular Mechanisms Underlying Anthracycline Cardiotoxicity: Challenges in Cardio-Oncology -- Introduction -- Impaired redox signaling -- Iron overload in mitochondria -- Calcium overload in mitochondria -- Altered mitochondrial dynamics in anthracyclines
Content:
Respiratory defects and altered metabolism in anthracycline cardiotoxicity -- Autophagy in anthracycline cardiotoxicity -- Deregulated molecular signaling pathways in anthracycline cardiotoxicity -- Gender-specific cardiotoxic effects of anthracycline -- Anthracyclines and cardiac remodeling -- Strategies to prevent doxorubicin cardiotoxicity -- Conclusions -- References -- Chapter 3 - Common Pathways in Cancer, Tumor Angiogenesis and Vascular Disease -- Introduction -- Hedgehog signaling -- Notch signaling -- Vascular targets for chemotherapy-angiogenesis
Content:
Vascular targets for chemotherapy-vasculogenic mimicry -- Vascular targets for chemotherapy-microvesicular trafficking -- Vascular targets for chemotherapy-vessel maturation -- Hedgehog and cancer biology -- Hedgehog inhibitors in cancer therapy -- Hedgehog and vascular biology -- Notch signaling and tumor biology -- Notch inhibitors -- Notch signaling and vascular biology -- Chemotherapy and vascular disease -- Conclusions -- References -- Chapter 4 - Molecular Mechanisms of Anthracycline-Induced Cardiotoxicity -- Historical and clinical perspectives -- Risk factors
Content:
Molecular mechanisms of DOX mediated cardiotoxicity
Note:
Description based upon print version of record
Additional Edition:
9780128035474
Additional Edition:
Print version Gottlieb, Roberta A Cardio-Oncology : Principles, Prevention and Management Saint Louis : Elsevier Science,c2016 9780128035474
Language:
English
Keywords:
Electronic books
URL:
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