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  • 1
    Book
    Book
    Córdoba : Palabras Editorial
    UID:
    (DE-627)1014797012
    Format: 184 Seiten
    Edition: 1a ed.
    ISBN: 9789872629106
    Language: Spanish
    URL: Cover
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  • 2
    Book
    Book
    Córdoba : Palabras Editorial
    UID:
    (DE-602)gbv_1014797012
    Format: 184 Seiten
    Edition: 1a ed.
    ISBN: 9789872629106
    Language: Spanish
    URL: Cover
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  • 3
    Book
    Book
    Rio Tercero : Editorial Nudista
    UID:
    (DE-627)1670160858
    Format: 187 Seiten
    Edition: 1a ed.
    ISBN: 9789871959839
    Language: Spanish
    URL: Cover
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  • 4
    Online Resource
    Online Resource
    Ciudad Autónoma de Buenos Aires : Elio Martín Maigua
    UID:
    (DE-627)174989503X
    Format: 1 online resource (101 pages)
    ISBN: 9789871959907
    Content: Intro -- Prólogo -- 1 -- 2 -- 3 -- 4 -- 5 -- 6 -- 7 -- 8 -- 9 -- 10 -- 11 -- 12 -- 13 -- 14 -- 15 -- 16 -- 17 -- 18 -- 19 -- 20 -- 21 -- 22 -- 23 -- 24 -- 25 -- 26 -- 27 -- 28 -- 29 -- 30 -- 31 -- 32 -- 33 -- Epílogo -- Acerca del Autor -- Agradecimientos del Autor.
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: 9789871959839
    Additional Edition: Erscheint auch als Druck-Ausgabe 9789871959839
    Language: Spanish
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  • 5
    Book
    Book
    Rio Tercero : Editorial Nudista
    UID:
    (DE-602)gbv_1670160858
    Format: 187 Seiten
    Edition: 1a ed.
    ISBN: 9789871959839
    Language: Spanish
    URL: Cover
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  • 6
    Book
    Book
    Buenos Aires : Eudeba
    UID:
    (DE-627)1093271523
    Format: 108 S.
    Series Statement: Serie del siglo y medio 83
    Language: Spanish
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  • 7
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : Universidad Complutense de Madrid
    UID:
    (DE-627)1803317086
    Content: La presente Tesis Doctoral pretende conocer la situación real de consumo de sustancias en la población de menores protegidos, así como detectar las variables predictoras del consumo o la abstinencia en dicha población. Resultados y conclusiones Se obtiene una tipología de consumo específica: mayores prevalencias para todas las sustancias y frecuencias, diferentes preferencias respecto a las sustancias de elección, menores edades de inicio en el consumo y en general, mayores porcentajes de consumo en el caso de las mujeres. Todos los conjuntos de variables estudiados son pronosticadores significativos del consumo de drogas, específicos para esta población y para las distintas drogas, si bien su peso y dirección no son los mismos en todos los casos. Alcohol, tabaco y cánnabis Factores riesgo: búsqueda de emociones y comportamientos destructivos, sentimiento de integración del centro en el barrio, relación con los compañeros del centro, acceso a cánnabis y cerveza, percepción de riesgo del consumo de cocaína; amigos que consumen alcohol, tabaco o cánnabis, presión iguales para fumar o beber, ir a pubs, bares y discotecas y participar en asociaciones o grupos reglados, faltar a clase y tener buenas relaciones con los compañeros de clase. Factores protección: práctica religión, empatía y contacto con la familia, valoración positiva centro, búsqueda de apoyo y cercanía afectiva con los adultos del centro, riesgo percibido del consumo de cánnabis y alucinógenos, práctica actividades de tiempo libre (escuchar música, leer tebeos o dibujar), valoración positiva de la formación recibida en el colegio y buena valoración de sí mismo como estudiante. Otras drogas ilegales Factores riesgo: realización de actos vandálicos; acceso a anfetaminas, consumo de anfetaminas e inhalantes de los amigos y acudir a conciertos. Factores protección: prohibición de no consumir drogas en el centro, percepción de riesgo consumo de cocaína y tener buena consideración de sí mismo como estudiante. [ABSTRACT]This PhD Thesis is intended to both understand the real situation of substance consumption within the framework of protected minors and to detect the predictor variables concerning consumption or abstinence among this population. Results and conclusions A typology of specific consumption is obtained: higher prevalence for all substances and frequencies, different preferences in relation to choice substances, lower starting ages concerning consumption and, in general terms, higher consumption rates concerning women. All the studied sets of variables are meaningful forecasters of drug consumption, specific to this population and to the different drugs, although their importance and path are not the same in all cases. Alcohol, tobacco and cannabis Risk factors: Search for emotions and destructive behaviours; neighbourhood integration feeling of the center; relationship with colleagues in the center; access to cannabis and beer; risk perception of cocaine use; friends who use alcohol, tobacco or cannabis; pressure from equals to smoke or drink; tendency to go to pubs, bars and clubs and to participate in associations or regulated groups, truancy and have good relationships with classmates. Protective factors: religion practise, empathy and family contact, positive centre assessment, search for support and emotional proximity to adults from the center, perceived risk of cannabis and hallucinogens use, leisure activities practise (listening to music, reading comics or drawing), positive consideration of school training and self-good consideration as student. Other illegal drugs Risk Factors: conducting vandalism, amphetamines access, amphetamines and inhalants use by friends and concerts attendance. Protective factors: drug prohibition in the center, risk perception concerning cocaine use and self-good consideration as student
    Note: Dissertation Universidad Complutense de Madrid 2013
    Language: Spanish
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  • 8
    UID:
    (DE-627)1574258621
    Format: 11
    ISSN: 1759-4782
    Content: In the past decade, the landscape of drug development in oncology has evolved dramatically; however, this paradigm shift remains to be adopted in early phase clinical trial designs for studies of molecularly targeted agents and immunotherapeutic agents in paediatric malignancies. In drug development, prioritization of drugs on the basis of knowledge of tumour biology, molecular 'drivers' of disease and a drug's mechanism of action, and therapeutic unmet needs are key elements; these aspects are relevant to early phase paediatric trials, in which molecular profiling is strongly encouraged. Herein, we describe the strategy of the Innovative Therapies for Children with Cancer (ITCC) Consortium, which advocates for the adoption of trial designs that enable uninterrupted patient recruitment, the extrapolation from studies in adults when possible, and the inclusion of expansion cohorts. If a drug has neither serious dose-related toxicities nor a narrow therapeutic index, then studies should generally be started at the adult recommended phase II dose corrected for body surface area, and act as dose-confirmation studies. The use of adaptive trial designs will enable drugs with promising activity to progress rapidly to randomized studies and, therefore, will substantially accelerate drug development for children and adolescents with cancer.
    Note: Gesehen am 08.05.2018
    In: Nature reviews. Clinical oncology, New York, NY : Nature Publ. Group, 2009, 14(2017), 8, Seite 497-507, 1759-4782
    In: volume:14
    In: year:2017
    In: number:8
    In: pages:497-507
    In: extent:11
    Language: English
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  • 9
    Book
    Book
    Buenos Aires : Ed. Univ. de Buenos Aires
    UID:
    (DE-627)496299816
    Format: 108 S. , 19 cm
    Series Statement: Serie del siglo y medio 83
    Language: Spanish
    URL: Cover
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  • 10
    Online Resource
    Online Resource
    [Erscheinungsort nicht ermittelbar] : [Verlag nicht ermittelbar]
    UID:
    (DE-627)180342642X
    Content: Tesis doctoral inédita realizada en en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Pediatría y el Hospital 'The Royal Marsden'. Fecha de lectura: 10 de Abril de 2012.
    Note: Dissertation 2014
    Language: English
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