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  • 1
    UID:
    (DE-602)b3kat_BV045429315
    Format: 1 Online-Ressource (95 Seiten) , Illustrationen, Diagramme
    Note: Dissertation Humboldt-Universität zu Berlin 2018
    Additional Edition: Erscheint auch als Druck-Ausgabe Murugan, Rajagopal Protective memory B cell response in controlled human malaria infection
    Language: English
    Subjects: Biology , Medicine
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    Keywords: Hochschulschrift
    URL: Volltext  (kostenfrei)
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  • 2
    UID:
    (DE-602)b3kat_BV045513170
    Format: 95 Seiten , Illustrationen, Diagramme
    Note: Dissertation Humboldt-Universität zu Berlin 2018
    Additional Edition: Erscheint auch als Online-Ausgabe Murugan, Rajagopal Protective memory B cell response in controlled human malaria infection 10.18452/19695
    Language: English
    Subjects: Biology , Medicine
    RVK:
    RVK:
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    Keywords: Hochschulschrift
    URL: Volltext  (kostenfrei)
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  • 3
    UID:
    (DE-604)BV045429315
    Format: 1 Online-Ressource (95 Seiten) , Illustrationen, Diagramme
    Note: Dissertation Humboldt-Universität zu Berlin 2018
    Additional Edition: Erscheint auch als Druck-Ausgabe Murugan, Rajagopal Protective memory B cell response in controlled human malaria infection
    Language: English
    Subjects: Biology , Medicine
    RVK:
    RVK:
    RVK:
    Keywords: Hochschulschrift
    URL: Volltext  (kostenfrei)
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  • 4
    UID:
    (DE-627)832509809
    Format: Online-Ressource , illustrations
    Edition: Online-Ausg.
    ISBN: 9781634826952
    Series Statement: Hepatology research and clinical developments
    Content: Over the past few years, epidemiological studies have revealed that there is an increase of life threatening liver diseases worldwide. It becomes increasingly clear that developments in this field are moving so rapidly toward the creation of new drugs against these maladies. Numerous research articles and books have been published on various aspects of toxicities, symptoms, managements and health implications of the liver. Consequently, a catalogue of collective information of toxicities, various features of natural products, and remedies for the prevention of toxicities is needed. This book de
    Note: Includes bibliographical references and index , HEPATOTOXICITY: SYMPTOMS,MANAGEMENT AND HEALTH IMPLICATIONS; HEPATOTOXICITY: SYMPTOMS,MANAGEMENT AND HEALTH IMPLICATIONS; Library of Congress Cataloging-in-Publication Data; Contents; Acknowledgments; Foreword A; Foreword B; Foreword C; About the Editors; Synopsis; Chapter 1: Alcoholic Hepatotoxicity: Symptoms and Managements; Abstract; 1. Introduction; 1.1. Liver; 1.1.1. Regulatory Functions of Liver; 1.2. Liver Toxicity; 1.2.1. Drug Induced Hepatotoxicity; 1.2.2. Marker Enzymes for Hepatotoxicity; 1.3. Alcohol; 1.3.1. Alcohol Metabolism in Liver; 1.3.2. Oxidative Metabolism of Ethanol , 1.3.3. Non-Oxidative Metabolism of Ethanol1.4. Impact of Alcohol on Mitochondrial Functions; 1.5. Alcohol Effects on Erythrocyte; 1.6. Alcohol Effects on Stomach; 1.7. Alcohol Effects on Nervous System; 1.8. Alcohol Effects on the Liver; 2. Symptoms; 2.1. Signs and Symptoms of Alcohol Abuse; 2.2. Signs and Symptoms of Alcoholism; 3. Alcohol Management; 3.1. Initial Care Management; 3.2. Management for Alcohol Abuse; 3.3. Variable Treatments for Alcohol Abuse; 3.4. Herbal Treatments; Conclusion; References; Chapter 2: Potential Role of Polyphenols on Liver Health and Diseases; Abstract , IntroductionProperties, Use, and Classification of Phenolic; Compounds; Classification, Structures, and Sources of Flavonoids; Flavonols; Flavones; Flavan-3-ols; Flavanones and Chalcones; Anthocyanidins/Anthocyanins; Isoflavones; Classification, Structures, and Sources of Non-Flavonoids; Phenolic acids and its derivatives; Hydroxycinnamates; Aglycone forms; Stilbenes; Potential Role of Polyphenols in the Management, Prevention, and Treatment of Liver Diseases; Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH); Alcoholic-related liver diseases; Liver cancer , ReferencesChapter 3: Pathology of Hepatotoxicity; Abstract; Introduction; Normal Liver; Laboratory Evaluation of Liver Disease; Blood Tests; Patterns of Hepatic injury; Complications; Symptoms of Liver Damage; Prevention of Drug Hepatotoxicity; Before Marketing; After Marketing; Conclusion; References; Chapter 4: Hepatoprotective Effect of Phloroglucinol from South Indian Marine Macroalgae against Liver Disorders; Abstract; 1. Introduction; 1.1. Risk Factors; 1.1.1. Virus Mediated Liver Injury; 1.1.2. Hepatitis B Viral Infection; 1.1.3. Hepatitis C Viral Infection , 1.1.4. Drug Induced Liver Injury1.1.4.1. Rifampicin, Isoniazid (INH) Induced Hepatotoxicity; 1.1.4.2. Non Steroidal Anti-Inflammatory Drugs Induced Hepatotoxicity; 1.1.4.3. Anti HIV Drug Induced Hepatotoxicity; 1.1.4.4. Anti-Hyperlipidemic Drugs Induced Hepatotoxicity; 1.1.4.5. Alpha 1 - Antitrypsin Deficiency; 1.1.4.6. Aflatoxins; 1.3. Alcohol Induced Liver Injury; 1.4. Nonalcoholic Fatty Liver Damage (NAFLD); 1.4.1. Non-Alcoholic Steatohepatitis; 1.5. Schistosomal Infection Induced Liver Damage; 2. Hepatoprotective Agents; 2.1. Marine Environment; 2.1.1. Marine Algae , 2.1.2. Marine Brown Algae
    Additional Edition: 1634826957
    Additional Edition: 9781634826501
    Additional Edition: 9781634826952
    Additional Edition: Print version Hepatotoxicity
    Language: English
    URL: Volltext  (lizenzpflichtig)
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  • 5
    UID:
    (DE-627)1683878647
    Format: 10
    ISSN: 2470-9468
    Content: Memories of exposure - Protective memory B cell responses are shaped through multiple mechanisms, including clonal selection of naïve B cells and affinity maturation. Memory B cell responses are considered critical to the development of a successful malaria vaccine, and Murugan et al. characterize memory B cell responses to the Plasmodium falciparum circumsporozoite (PfCSP) protein in human volunteers immunized with sporozoites. They observed that repeated immunization induced potent responses to the immunodominant PfCSP NANP repeat by the clonal selection of naïve and preexisting memory B cell precursors and was less influenced by affinity maturation. Computational modeling indicated that these responses are shaped by the complexity of the antigen, and these findings provide a new perspective on protective B cell responses. - Affinity maturation, the clonal selection and expansion of antigen-activated B cells expressing somatically mutated antibody variants that develop during T cell-dependent germinal center reactions, is considered pivotal for efficient development of protective B cell memory responses to infection and vaccination. Repeated antigen exposure promotes affinity maturation but each time also recruits antigen-reactive naïve B cells into the response. Here, we determined the relative impact of affinity maturation versus antigen-mediated clonal selection of naïve B cells to mount potent B cell memory responses in humans after repeated exposure to a complex pathogen, the malaria parasite Plasmodium falciparum (Pf). Using single-cell immunoglobulin (Ig) gene sequencing and production of recombinant monoclonal antibodies, we analyzed the origin, development, and quality of memory B cell responses to Pf circumsporozoite protein (PfCSP), the major sporozoite surface protein. We show that after repeated immunization of Pf-naïve volunteers with infectious Pf sporozoites (PfSPZ Challenge) under chloroquine prophylaxis (PfSPZ-CVac), the clonal selection of potent germline and memory B cell precursors against the central PfCSP NANP repeat outpaces affinity maturation because the majority of Ig gene mutations are affinity-neutral. Mathematical modeling explains how the efficiency of affinity maturation decreases strongly with antigen complexity. Thus, in the absence of long-term exposure, the frequency of antigen-reactive precursors and likelihood of their activation rather than affinity maturation will determine the quality of anti-PfCSP memory B cell responses. These findings have wide implications for the design of vaccination strategies to induce potent B cell memory responses against PfCSP and presumably other structurally complex antigens. - The clonal selection of potent germline antibodies outpaces affinity maturation in human anti-PfCSP memory B cell responses. - The clonal selection of potent germline antibodies outpaces affinity maturation in human anti-PfCSP memory B cell responses.
    Note: Gesehen am 02.12.2019
    In: Science immunology, Washington, DC : AAAS, 2016, 3(2018,20) Artikel-Nummer eaap8029, 10 Seiten, 2470-9468
    In: volume:3
    In: year:2018
    In: number:20
    In: extent:10
    Language: English
    URL: Volltext  (Pay-per-use)
    URL: Volltext  (Pay-per-use)
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  • 6
    UID:
    (DE-627)1653743700
    Format: Online Ressource
    ISBN: 9781634853774 , 1634853776
    Series Statement: Digestive diseases--research and clinical developments
    Content: 1.1.2. Ulcerative Colitis (UC)1.1.3. Indeterminate Colitis (IC); 1.2. Historical Perspective and Research Advances; 1.3. Does an Environmental Factor Play a Role in IBD?; 1.4. "Westernization"; 1.5. Sanitation and Exposure to Infection; 1.6. Occupation; 1.7. Diet; 1.8. Tobacco Smoking; 1.9. Genetic Factors; 1.10. Familial and Ethnic Syndromes; 2. CURRENT LIMITATIONS OF IBD TREATMENT; 3. DRUG DISCOVERY AND ZEBRA FISH RESEARCH; 3.1. Zebra Fish -- Inflammation Research; 4. MICROBES CAUSING INFLAMMATION; 5. EXPERIMENTAL SETUP
    Content: 2.3. Chronic Gastritis2.4. Consequences; 3. THERAPY; 3.1. How Is Acute Gastritis Diagnosed?; 3.1.1. How Is Acute Gastritis Treated?; 3.2. How Is Chronic Gastritis Diagnosed?; 3.2.1. The Most Common Medicines to Reduce Gastric Acid Are; 3.2.2. Diet; 3.2.3. Recommended Foods Generally Include Foods with Small Amounts of the Following; 3.2.4. Recommended Foods Include; SUMMARY; ACKNOWLEDGMENTS; REFERENCES; Chapter 2: RESVERATROL AND ITS DERIVATIVES FOR THE PREVENTION AND TREATMENT OF GASTROINTESTINAL DISORDERS: A REVIEW; ABSTRACT; INTRODUCTION; STRUCTURE OF RESVERATROL AND ITS DERIVATIVES
    Content: 5.1. Extraction and Isolation of Fractionated Glycosaminoglycans (f-GAG)5.2. Maintenance of Stocks and Collection of Embryos; 5.3. Induction of IBD; 5.4. Optical Observation; 5.5. Histology and Staining; 5.6. Alcian Blue Staining; 5.7. Sudan Black Staining; 5.8. Antibacterial Activity; 5.9. Antibacterial Susceptibility Testing; 5.10. Statistics; 6. RESULTS AND DISCUSSION; 6.1. Optical Observation; 6.2. Histology; 6.3. Alcian Blue Staining; 6.4. Antibacterial Activity of f-GAG; 7. HYPOTHETICAL MECHANISM OF ACTION; CONCLUSION; ACKNOWLEDGMENTS; REFERENCES
    Content: DISORDERS OF GASTROINTESTINAL SYSTEMS AND CLINICAL MANIFESTATIONS; DISORDERS OF GASTROINTESTINAL SYSTEMS AND CLINICAL MANIFESTATIONS; Library of Congress Cataloging-in-Publication Data; CONTENTS; ACKNOWLEDGMENTS; FOREWORD A; Dr. P. Madeswaran, PhD; FOREWORD B; Palok Aich, PhD,; FOREWORD C; Qazi A. Hamid, Ph.D.,; ABOUT THE EDITORS; Dr. Senthilkumar Rajagopal; Dr. Sengottuvelan Murugan; Dr. Saravanan Ramachandran; SYNOPSIS; Chapter 1: UNDERSTANDING THE IMPACTS OF ALCOHOL: GASTRIC FUNCTIONS AND THERAPY; ABSTRACT; 1. INTRODUCTION; 2. THE GASTROINTESTINAL TRACT; 2.1. Stomach; 2.2. Acute Gastritis
    Content: RESVERATROL AND ITS DERIVATIVES IN ULCERATIVE COLITIS (UC)Resveratrol and Its Derivatives in Colon Cancer; Effects of Resveratrol and Its Derivatives on Colon Cancer Cells In Vitro; Effects of Resveratrol and Its Derivatives on Animal Models of Colon Cancer; EFFECTS OF RESVERATROL AND ITS DERIVATIVES ON ESOPHAGEAL AND STOMACH CANCER; CONCLUSION; REFERENCES; Chapter 3: ANTI-INFLAMMATORY EFFECT OF POLYMER FROM CEPHALOPOD AGAINST EXPERIMENTALLY INDUCED INTESTINAL BOWEL DISEASE IN ZEBRA FISH MODEL; ABSTRACT; 1. INTRODUCTION; 1.1. Types of IBD; 1.1.1. Crohn's Disease (CD)
    Note: Includes bibliographical references and index. - Online resource; title from PDF title page (EBSCO, viewed September 30, 2016)
    Additional Edition: 9781634853774
    Additional Edition: 1634853776
    Additional Edition: 9781634853668
    Additional Edition: 1634853660(hardcover)
    Additional Edition: 9781634853668 (hardcover)
    Additional Edition: Erscheint auch als Druck-Ausgabe Disorders of gastrointestinal systems and clinical manifestations New York : Nova Biomedical, [2016]
    Language: English
    Keywords: Electronic books ; Electronic books
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  • 7
    UID:
    (DE-627)869063499
    Format: 1 Online-Ressource (345 p)
    ISBN: 9781634853668
    Series Statement: Digestive Diseases - Research and Clinical Developments
    Content: DISORDERS OF GASTROINTESTINAL SYSTEMS AND CLINICAL MANIFESTATIONS -- DISORDERS OF GASTROINTESTINAL SYSTEMS AND CLINICAL MANIFESTATIONS -- Library of Congress Cataloging-in-Publication Data -- CONTENTS -- ACKNOWLEDGMENTS -- FOREWORD A -- Dr. P. Madeswaran, PhD -- FOREWORD B -- Palok Aich, PhD, -- FOREWORD C -- Qazi A. Hamid, Ph.D., -- ABOUT THE EDITORS -- Dr. Senthilkumar Rajagopal -- Dr. Sengottuvelan Murugan -- Dr. Saravanan Ramachandran -- SYNOPSIS -- Chapter 1: UNDERSTANDING THE IMPACTS OF ALCOHOL: GASTRIC FUNCTIONS AND THERAPY -- ABSTRACT -- 1. INTRODUCTION
    Note: Description based upon print version of record
    Additional Edition: 9781634853774
    Additional Edition: 9781634853668
    Additional Edition: Print version Rajagopal, Senthilkumar Disorders of Gastrointestinal Systems and Clinical Manifestations Hauppauge : Nova Science Publishers, Inc.,c2016 9781634853668
    Language: English
    Keywords: Electronic books
    URL: Volltext  (lizenzpflichtig)
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  • 8
    UID:
    (DE-101)1182541283
    Format: Online-Ressource
    Note: Dissertation Berlin, Humboldt-Universität zu Berlin 2018
    Language: English
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  • 9
    UID:
    (DE-603)448529343
    Format: Online-Ressource
    Note: Dissertation Berlin, Humboldt-Universität zu Berlin 2018
    Language: English
    Keywords: Hochschulschrift
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  • 10
    UID:
    (DE-627)1674134304
    Format: 1 Online-Ressource
    Note: Dissertation Berlin, Humboldt-Universität zu Berlin 2018
    Language: English
    Keywords: Hochschulschrift
    URL: Volltext  (kostenfrei)
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