Format:
Online-Ressource
ISSN:
1613-4133
Content:
Abstract: Hyperglycemia, abnormal lipid and antioxidant profiles are the most usual complications in diabetes mellitus. Thus, in this study, we investigated the anti‐diabetic and anti‐oxidative effects of anthocyanins (ANT) from black soybean seed coats in streptozotocin (STZ)‐induced diabetic rats. The administration of ANT markedly decreased glucose levels and improved heart hemodynamic function (left ventricular end diastolic pressure, ±dp/dt parameters). ANT not only enhanced STZ‐mediated insulin level decreases, but also decreased the triglyceride levels induced by STZ injection in serum. Diabetic rats exhibited a lower expression of glucose transporter 4 proteins in the membrane fractions of heart and skeletal muscle tissues, which was enhanced by ANT. In addition, ANT activated insulin receptor phosphorylation, suggesting an increased utilization of glucose by tissues. Moreover, ANT protected pancreatic tissue from STZ‐induced apoptosis through regulation of caspase‐3, Bax, and Bcl‐2 proteins. Furthermore, ANT significantly suppressed malondialdehyde levels and restored superoxide dismutase and catalase activities in diabetic rats. Interestingly, the observed effects of ANT were superior to those of glibenclamide. Taken together, ANT from black soybean seed coat have anti‐diabetic effects that are due, in part, to the regulation of glucose transporter 4 and prevention of insulin resistance and pancreatic apoptosis, suggesting a possible use as a drug to regulate diabetes.
In:
volume:53
In:
number:11
In:
year:2009
In:
pages:1419-1429
In:
extent:11
In:
Molecular nutrition & food research, Weinheim : Wiley-VCH, [2004]-, 53, Heft 11 (2009), 1419-1429 (gesamt 11), 1613-4133
Language:
English
DOI:
10.1002/mnfr.200800526
URN:
urn:nbn:de:101:1-2023060707244728531514
URL:
https://doi.org/10.1002/mnfr.200800526
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023060707244728531514
URL:
https://d-nb.info/1292230290/34
URL:
https://doi.org/10.1002/mnfr.200800526
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