Format:
1 Online-Ressource (320 pages)
ISBN:
9780128153826
Series Statement:
International Review of Cell and Molecular Biology Ser v.Volume 342
Content:
Front Cover -- International Review of Cell and Molecular Biology -- INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY -- Biology of T Cells - Part B -- Copyright -- Contents -- CONTRIBUTORS -- T CELLS: FRIENDS AND FOES -- Acknowledgments -- REFERENCES -- One - Stimulating T Cells Against Cancer With Agonist Immunostimulatory Monoclonal Antibodies -- 1. INTRODUCTION -- 2. CD137 -- 3. GITR -- 4. OX40 -- 5. CD27 -- 6. EMERGING AGONISTS: ICOS AND CD40 -- 7. CD28 SUPERAGONIST AS A CAUTIONARY TALE -- 8. CONCLUSIONS -- REFERENCES -- Two - T Cells and Regulated Cell Death: Kill or Be Killed -- 1. INTRODUCTION -- 2. CELL DEATH PATHWAYS IN T CELLS -- 2.1 Apoptosis -- 2.1.1 The Intrinsic Apoptotic Pathway -- 2.1.2 The Extrinsic Apoptotic Pathway -- 2.1.3 Cross Talk Between the Intrinsic and Extrinsic Pathways -- 2.1.4 Thymocyte Maturation and Selection -- 2.2 Necroptosis -- 2.3 Pyroptosis -- 2.4 Ferroptosis -- 3. T CELL-MEDIATED CELL DEATH -- 3.1 Granule Exocytosis -- 3.2 Death Ligand Secretion -- 3.3 Immunosurveillance -- 3.4 Cancer Immunotherapy -- 4. CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES -- Three - Macrophages: Their Untold Story in T Cell Activation and Function -- 1. INTRODUCTION -- 2. MACROPHAGES AS EFFICIENT APCS -- 3. CROSS-PRESENTATION AND TCR ENGAGEMENT OF THE MHC SERVES AS SIGNAL 1 -- 4. SIGNAL 2: COSTIMULATORY AND INHIBITORY RECEPTORS ON MACROPHAGES -- 5. SIGNAL 3: ENVIRONMENTAL CYTOKINE PRODUCTION DIRECTS T CELL DIFFERENTIATION AND EFFECTOR FUNCTION -- 6. THE ROLE OF MACROPHAGES ON T CELL INHIBITION AND EXHAUSTION -- 7. TUMOR-ASSOCIATED MACROPHAGES -- ACKNOWLEDGMENTS -- REFERENCES -- Four - Metabolism of T Lymphocytes in Health and Disease -- 1. INTRODUCTION -- 2. METABOLIC PATHWAYS: AN OVERVIEW -- 2.1 Glycolysis and the Pentose Phosphate Pathway -- 2.2 Tricarboxylic Acid Cycle and Oxidative Phosphorylation
Content:
2.3 Fatty Acid Synthesis and Fatty Acid Oxidation -- 2.4 Amino Acids and Glutaminolysis -- 3. T CELLS POSSESS A SPECIFIC METABOLIC PROFILE THAT IS CRUCIAL FOR SURVIVAL AND FUNCTION -- 4. METABOLIC PATHWAYS TO MAINTAIN T-CELL HOMEOSTASIS -- 5. METABOLIC REPROGRAMMING UPON ENGAGEMENT OF EFFECTOR T CELLS -- 5.1 Aerobic Glycolysis and Pentose Phosphate Pathway in Effector T Cells Under the Control of Mechanistic Target of Rapamycin -- 5.2 Glycolytic Enzymes and Metabolites in the Regulation of Effector T-Cell Functions -- 5.3 Glutamine Metabolism in Effector T Cells -- 5.4 TCA Cycle and OxPhos in Effector T Cells -- 5.5 Fatty Acid Metabolism in Effector T Cells -- 6. IMMUNOMETABOLISM OF REGULATORY T CELLS -- 6.1 Different Treg Subsets Have Distinct Glycolytic Demands -- 6.2 Treg Cells Use Free FAs for FAO -- 7. METABOLIC RECONFIGURATION IN T-CELL MEMORY AND LONGEVITY -- 7.1 Different Memory T-Cell Subsets Have Distinct Metabolic Profiles -- 7.2 Futile Cycle of FAS and FAO in Memory T Cells Facilitates Rapid and Robust Recall Response -- 7.3 Regulation of Memory T Cells Metabolism -- 8. TUMOR MICROENVIRONMENT SHAPES T-CELL METABOLISM AND FUNCTION -- 8.1 Competition for Nutrients in the Tumor Environment -- 8.2 Tumor-Derived Hypoxia and Acidosis Affect T-Cell Metabolism and Function -- 8.3 Challenges and Opportunities for Cancer Treatment by Adoptive T Cell Therapy -- 9. T-CELL METABOLISM IN AUTOIMMUNITY -- 9.1 Hyperactivated T-Cell Metabolism in Systemic Lupus Erythematosus -- 9.2 Naive CD4+ T Cells From Patients With Rheumatoid Arthritis Possess an "Anti-Warburg Effect" -- 9.3 Reprogramming T Cell Metabolism and Fate as a New Therapeutic Approach in Autoimmune Disorders -- 10. CONCLUSION -- REFERENCES -- Five - Cancer Immunosurveillance by T Cells -- 1. WHAT IS CANCER IMMUNOSURVEILLANCE? -- 1.1 Historical Background -- 1.2 Immunoediting: The Three E's
Content:
2. WHAT ROLE DO T-CELL SUBSETS PLAY IN CANCER IMMUNOSURVEILLANCE? -- 2.1 Immune Infiltration and Cancer Prognosis -- 2.2 T-Cell Subsets in Cancer -- 3. IMMUNE CHECKPOINTS AND IMMUNOSURVEILLANCE-A DELICATE BALANCE -- 4. WHAT ROLE DO TUMOR ANTIGENS PLAY IN CANCER IMMUNOSURVEILLANCE? -- 4.1 Antigens Within Tumors -- 4.2 T-Cell Repertoire Fitness -- 5. CONCLUSIONS -- REFERENCES -- Six - T Lymphocytes as Measurable Targets of Protection and Vaccination Against Viral Disorders -- 1. INTRODUCTION -- 2. RESPIRATORY VIRUS DISORDERS -- 2.1 Influenza Virus Classification, Epidemiology, Immunology, and Vaccinology -- 2.2 Parainfluenza Virus Classification, Epidemiology, Immunology, and Vaccinology -- 2.3 Respiratory Syncytial Virus Classification, Epidemiology, Immunology, and Vaccinology -- 2.4 Adenovirus Classification, Epidemiology, Immunology, and Vaccinology -- 2.5 Respiratory Virus Disorders and Adaptive Immune Responses Summary -- 3. VIRAL GASTROENTERITIS DISORDERS -- 3.1 RV Classification, Epidemiology, Immunology, and Vaccinology -- 3.2 Viral Gastroenteritis Disorders and Adaptive Immune Responses Summary -- 4. EXANTHEMATOUS VIRAL DISORDERS -- 4.1 Rubeola Virus Classification, Epidemiology, Immunology, and Vaccinology -- 4.2 Rubella Virus Classification, Epidemiology, Immunology, and Vaccinology -- 4.3 VZV Classification, Epidemiology, Immunology, and Vaccinology -- 4.4 Variola Virus Classification, Epidemiology, Immunology, and Vaccinology -- 4.5 Exanthematous Viral Disorders and Adaptive Immune Responses Summary -- 5. HEPATIC VIRAL DISORDERS -- 5.1 Hepatitis Virus Classification, Epidemiology, Immunology, and Vaccinology -- 5.2 Hepatic Viral Disorders and Adaptive Immune Responses Summary -- 6. NEUROLOGIC VIRAL DISORDERS -- 6.1 PV Classification, Epidemiology, Immunology, and Vaccinology
Content:
6.2 Flavivirus Classification, Epidemiology, Immunology, and Vaccinology -- 6.3 Alphavirus Classification, Epidemiology, Immunology, and Vaccinology -- 6.4 RABV Classification, Epidemiology, Immunology, and Vaccinology -- 6.5 Neurologic Viral Disorders and Adaptive Immune Responses Summary -- 7. HEMORRHAGIC FEVER VIRAL DISORDERS -- 7.1 Flavivirus Classification, Epidemiology, Immunology, and Vaccinology -- 7.2 Mammarenavirus Classification, Epidemiology, Immunology, and Vaccinology -- 7.3 Filoviruses Classification, Epidemiology, Immunology, and Vaccinology -- 7.4 Orthonairovirus Classification, Epidemiology, Immunology, and Vaccinology -- 7.5 Hemorrhagic Fever Viral Disorders and Adaptive Immune Responses Summary -- 8. PERSPECTIVES -- ACKNOWLEDGMENTS -- CONTRIBUTIONS -- REFERENCES -- Seven - In Silico Methods for Studying T Cell Biology -- 1. INTRODUCTION -- 2. CYTOMETRY WITH TIME OF FLIGHT -- 3. IMMUNE INFILTRATION ANALYSIS FROM TRANSCRIPTOMIC DATA -- 4. INFERRING TCR CLONOTYPES FROM RNASEQ DATA -- 5. T CELL RECEPTOR SEQUENCING -- 6. PEPTIDE/MHC DYNAMICS AND IMMUNOGENICITY PREDICTIONS -- 7. MATHEMATICAL MODELING OF T CELL DYNAMICS -- 8. DATABASES FOR STUDYING T CELLS BIOLOGY -- 8.1 The Cancer Immunome Atlas -- 8.2 Immunological Genome Project -- 8.3 International ImMunoGeneTics Information System -- 8.4 Roadmap Epigenomics Project -- 8.5 Adaptive Biotechnology ImmunoSEQ Analyzer -- 8.6 Flow Repository -- 8.7 Cistrome -- 8.8 Gene Expression Omnibus -- 9. CONCLUSIONS -- REFERENCES -- Back Cover
Additional Edition:
9780128153819
Additional Edition:
Print version Galluzzi, Lorenzo Biology of T Cells - Part B San Diego : Elsevier Science & Technology,c2019 9780128153819
Language:
English
URL:
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