Format:
22
,
Illustrationen
ISSN:
1540-9538
Content:
CD8 T lymphocytes are classically viewed as cytotoxic T cells. Whether human CD8 T cells can, in parallel, induce a tissue regeneration program is poorly understood. Here, antigen-specific assay systems revealed that human CD8 T cells not only mediated cytotoxicity but also promoted tissue remodeling. Activated CD8 T cells could produce the epidermal growth factor receptor (EGFR)-ligand amphiregulin (AREG) and sensitize epithelial cells for enhanced regeneration potential. Blocking the EGFR or the effector cytokines IFN-γ and TNF could inhibit tissue remodeling. This regenerative program enhanced tumor spheroid and stem cell-mediated organoid growth. Using single-cell gene expression analysis, we identified an AREG+, tissue-resident CD8 T cell population in skin and adipose tissue from patients undergoing abdominal wall or abdominoplasty surgery. These tissue-resident CD8 T cells showed a strong TCR clonal relation to blood PD1+TIGIT+ CD8 T cells with tissue remodeling abilities. These findings may help to understand the complex CD8 biology in tumors and could become relevant for the design of therapeutic T cell products.
Note:
Gesehen am 18.03.2024
In:
Journal of experimental medicine, New York, NY : Rockefeller Univ. Press, 1896, 221(2024), 2, Artikel-ID e20230488, Seite 1-22, 1540-9538
In:
volume:221
In:
year:2024
In:
number:2
In:
elocationid:e20230488
In:
pages:1-22
In:
extent:22
Language:
English
DOI:
10.1084/jem.20230488
URL:
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