UID:
(DE-602)edoccha_9959228676102883
Format:
1 online resource (339 p.)
ISBN:
1-281-04644-2
,
9786611046446
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0-08-052888-0
Series Statement:
Cell biology
Content:
The first of its kind, this volume presents the latest research findings on the chaperonins, the best studied family of a class of proteins known as molecular chaperones. These findings are changing our view of some fundamental cellular processes involving proteins, especially how proteins fold into their functional conformations.Key Features* Origins of the new view of protein folding* Prokaryotic chaperonins* Eukaryotic chaperonins* Evolution of the chaperonins* Refolding of denatured proteins* Organelle biosynthesis* Biomedical aspects
Note:
Description based upon print version of record.
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Front Cover; The Chaperonins; Copyright Page; Contents; Contributors; Preface; Chapter 1. Chaperonins: Introductory Perspective; I. Origins; II. General Concept of Molecular Chaperones; III. Definitions and Nomenclature; IV. Functions of Chaperonins; V. Problems; References; Chapter 2. Evolutionary Relationships of Chaperonins; I. Introduction; II. Chaperonin 60 and Chaperonin 10 Gene Families; III. t-Complex Polypeptide 1 Gene Family; IV. Evolutionary Relationship of t-Complex Polypeptide 1 and Chaperonin 60 Gene Families and Origin of Eukaryotic Cells; References
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Chapter 3. Chaperonins of Photosynthetic OrganismsI. Introduction; II. Chloroplast Chaperonins; III. Chaperonin 60 and Chaperonin 10 in Mitochondria from Angiosperms; IV. Chaperonin 60 and Chaperonin 10 in Photosynthetic Prokaryotic Organisms; V. Concluding Comments; References; Chapter 4. Chaperonin-Mediated Folding and Assembly of Proteins in Mitochondria; I. Introduction; II. Mitochondrial Chaperonin 60; III. Mitochondrial Chaperonin 60 as Stress Protein; IV. Regulation of Mitochondrial Chaperonin 60 Function by Mitochondrial Chaperonin 10
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V. Role of Mitochondrial Chaperonin 60 Machinery in Intramitochondrial Protein SortingVI. Cooperation of Mitochondrial Chaperonin 60 with Mitochondrial Heat Shock Protein 70 Machinery; VII. Perspectives; References; Chapter 5. Structure and Function of Chaperonins in Archaebacteria and Eukaryotic Cytosol; I. Introduction; II. Archaebacterial Chaperonins; III. t-Complex Polypeptide 1 in Eukaryotic Cytosol; IV. CCT Analysis in Yeast; V. Evolution; VI. Conclusions; References; Chapter 6. Regulation of Chaperonin Gene Expression; I. Introduction; II. Chaperonin Gene Organization
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III. Induction of Chaperonin Synthesis in Response to StressIV. Regulation of Escherichia coli Chaperonin Genes; V. Regulation of Chaperonin Genes in Other Bacteria, Including Gram- Positive Bacteria; VI. Modulation of Chaperonin Activity by Bacteriophage Gp31 Protein; VII. Concluding Remarks; References; Chapter 7. Kinetic and Energetic Aspects of Chaperonin Function; I. Ground Rules of Chaperonin Behavior; II. Avoidance of Dead Ends; III. Spontaneous Protein Folding; IV. Energy Transduction: Role of ATP in Chaperonin Activity; V. Conformation of Bound Protein Substrates
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VI. General Models of Chaperonin ActionReferences; Chapter 8. Role of Prokaryotic Chaperonins in Protein Folding; I. Introduction; II. Pathway of Chaperone-Assisted Protein Folding; III. Mechanism of Chaperonin-Mediated Protein Folding; IV. Conformational Properties of Chaperonin-Bound Proteins; V. Role of Chaperonins in Oligomeric Protein Assembly; VI. Chaperonin Function under Cellular Stress Conditions; VII. Concluding Remarks; References; Chapter 9. Chaperonin Structure and Conformational Changes; I. Introduction: Methods for Structural Studies of Chaperonins
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II. Arrangement of Subunit Domains in Chaperonin 60 Oligomer
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English
Additional Edition:
ISBN 0-12-237455-X
Language:
English
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