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  • 1
    Online Resource
    Online Resource
    Tumor Organoids (2017)
    Cham : Springer International Publishing AG
    Details
    UID:
    (DE-627)1797561146
    Format: 1 Online-Ressource (225 pages)
    ISBN: 9783319605111
    Series Statement: Cancer Drug Discovery and Development
    Additional Edition: 9783319605098
    Additional Edition: Erscheint auch als Druck-Ausgabe Soker, Shay Tumor Organoids Cham : Springer International Publishing AG,c2017 9783319605098
    Language: English
    URL: lizenzpflichtig
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  • 2
    Online Resource
    Online Resource
    Tumor Organoids (2018)
    Cham : Springer International Publishing
    Details
    UID:
    (DE-605)HT019678761
    Format: 1 Online-Ressource (XVI, 213 p. 52 illus., 50 illus. in color)
    ISBN: 9783319605111
    Series Statement: Cancer Drug Discovery and Development
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783319605098
    Language: English
    DOI: 10.1007/978-3-319-60511-1
    URL: http://dx.doi.org/10.1007/978-3-319-60511-1
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  • 3
    Online Resource
    Online Resource
    Tumor Organoids (2018)
    Cham : Springer International Publishing
    Details
    UID:
    (DE-604)BV044662213
    Format: 1 Online-Ressource (XVI, 213 p. 52 illus., 50 illus. in color)
    ISBN: 9783319605111
    Series Statement: Cancer Drug Discovery and Development
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-319-60509-8
    Language: English
    DOI: 10.1007/978-3-319-60511-1
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 4
    Online Resource
    Online Resource
    Tumor Organoids (2018)
    Cham : Springer International Publishing
    Details
    UID:
    (DE-602)b3kat_BV044662213
    Format: 1 Online-Ressource (XVI, 213 p. 52 illus., 50 illus. in color)
    ISBN: 9783319605111
    Series Statement: Cancer Drug Discovery and Development
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-319-60509-8
    Language: English
    DOI: 10.1007/978-3-319-60511-1
    URL: Volltext  (URL des Erstveröffentlichers)
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  • 5
    Online Resource
    Online Resource
    Tumor Organoids (2017)
    Cham : Springer International Publishing
    Details
    UID:
    (DE-627)100285010X
    Format: 1 Online-Ressource (225 pages)
    ISBN: 9783319605111
    Series Statement: Cancer Drug Discovery and Development
    Content: "Dedication" -- "Contents" -- "Contributors" -- "Introduction" -- "Techniques to Produce and Culture Lung Tumor Organoids" -- "1 Introduction" -- "2 Techniques" -- "2.1 Matrigel" -- "2.2 Maglev" -- "2.3 Rotating Wall Vessel" -- "2.4 Hanging Drop" -- "2.5 Non-adherent Cultures" -- "3 Discussion" -- "References" -- "Tissue Organoids: Liver" -- "1 Introduction" -- "2 Strategies for the Generation of Hepatic Tissue" -- "2.1 Hepatocyte Aggregates and Spheroids" -- "2.2 Liver Tissue Engineering" -- "2.3 Liver Bioengineering and Liver Organoids" -- "2.4 Future Perspectives" -- "3 Drug Development and Toxicology" -- "3.1 Need of Engineered Liver Tissues for Drug Development" -- "3.2 Limitations of Current In Vitro Liver Models to Test Drugs" -- "3.3 Organoids in Drug Development" -- "3.4 Cancer Research" -- "4 Conclusions" -- "References" -- "Mammary Gland Organoids" -- "1 The Mammary Gland" -- "2 Model Systems to Study Mammary Gland Development: 2D Vs 3D" -- "3 Mammary Gland Organoids" -- "4 Key Finding Using Primary Mammary Organoids as a Model of Development" -- "5 Primary Mammary Organoids as a Platform to Understand Mechanisms Involved in Carcinogenesis" -- "6 Concluding Remarks" -- "References" -- "Biofabrication Technologies for Developing In Vitro Tumor Models" -- "1 Introduction" -- "2 Tumor Spheroids" -- "2.1 Homogeneous Spheroids" -- "2.2 Heterogeneous Spheroids" -- "3 Biofabricated Tumor Constructs" -- "3.1 Rotating Wall Vessel" -- "3.2 Three Dimensional Bioprinting" -- "3.3 Photopatterning" -- "3.4 Tumor-on-a-Chip" -- "3.5 Metastasis-on-a-Chip" -- "4 Patient-Specific Tumor Models for Personalized Medicine" -- "5 Conclusions" -- "References" -- "Three Dimensional In Vitro Tumor Platforms for Cancer Discovery" -- "1 Collagen Characterization for the Use of Tumor Platform" -- "2 3D In Vitro Collagen Tumor Models
    Content: "3 Microfluidic Vascularized Tumor Platform" -- "4 Conclusion" -- "References" -- "Tissue-Engineered Models for Studies of Bone Metastasis" -- "1 Introduction" -- "2 The Microenvironment in Bone Metastasis" -- "2.1 Bone Structure and Homeostatic Bone Remodeling" -- "2.2 The Vicious Cycle of Bone Metastasis" -- "3 In Vivo Models of Bone Metastasis" -- "4 Tissue-Engineered Models to Study Bone Metastasis" -- "4.1 Dimensionality: 2D Versus 3D" -- "4.2 Cell-Matrix Interactions" -- "4.2.1 Organic Matrix (Collagen, Decellularized Matrices, etc.)" -- "4.2.2 Inorganic Matrix (Mineral)" -- "4.3 Cell-Cell Interactions" -- "4.3.1 Direct: Cell-Cell Contact in Co-cultures of Tumor and Bone Cells" -- "4.3.2 Indirect: Membranes, Cell-Derived Factors, Soluble Cues" -- "4.4 Mechanical Forces" -- "5 Future Perspectives" -- "References" -- "Building Better Tumor Models: Organoid Systems to Investigate Angiogenesis" -- "1 Introduction" -- "2 Cell Signaling Pathways in Tumor Angiogenesis" -- "3 Organoid Systems to Model Angiogenesis" -- "4 Hypoxia and Tumor Angiogenesis" -- "4.1 Overview" -- "4.2 Controlling and Measuring Oxygen In Vitro" -- "5 Cellular Metabolism and Angiogenesis in the Tumor Microenvironment" -- "5.1 Overview" -- "5.2 Methods to Characterize Cellular Metabolism In Vitro" -- "6 Biomechanics in Tumor-Associated Angiogenesis" -- "6.1 Overview" -- "6.2 Angiogenesis Models to Elucidate the Impact of Mechanical Forces" -- "7 Intravasation and Extravasation in Tumor-Associated Angiogenesis" -- "7.1 Overview" -- "7.2 Methods to Investigate Intravasation and Extravasation of Tumor Cells" -- "8 Summary and Future Directions" -- "References" -- "Microfluidics in Cell and Tissue Studies" -- "1 Introduction" -- "2 Microfluidic Devices" -- "3 Interfacing Single Cells with Microfluidic Systems
    Content: "4 Interfacing 2D Cell Culture with Microfluidic Systems" -- "5 Interfacing 3D Cell Culture with Microfluidic Systems" -- "6 Analytical Approaches Interfaced with Microfluidics" -- "7 Conclusions" -- "References" -- "Stiffness-Tuned Matrices for Tumor Cell Studies" -- "1 Matrix Stiffness Regulates Cell Behavior" -- "2 Ideal Properties of a Stiffness Model" -- "3 Collagen I Structure and Mechanics" -- "4 Stiffening Collagen I Matrices" -- "5 Measuring Stiffness with Atomic Force Microscopy (AFM)" -- "6 Method for Tuning Collagen I Stiffness" -- "6.1 Functionalization of Collagen I" -- "6.2 Photoinitiator Synthesis" -- "6.3 Photoactivation of Cross-Links in Collagen" -- "6.4 Calibrating the AFM for Stiffness Measurements" -- "6.5 Collagen I-GMA Spanned the Range of Breast Cancer-­Relevant Stiffnesses" -- "7 Matrix Stiffness Affects Invasive Behavior" -- "8 Migration Assay on Stiffness-Tuned Collagen I" -- "9 Conclusions" -- "References" -- "Mathematical Modeling of Tumor Organoids: Toward Personalized Medicine" -- "1 Introduction" -- "2 In Silico Organoid Model of Mammary Acini" -- "2.1 Outline of Our Approach" -- "2.2 The IBCell Model" -- "2.3 IBCell Calibration" -- "2.4 IBCell Morphocharts" -- "2.5 Double-Tuning of IBCell" -- "2.6 Identification of Potential Mechanisms of Mutant Development" -- "2.7 Experimental Validation" -- "2.8 Genotype-to-Phenotype Bridging with IBCell" -- "3 In Silico Organotypic Model for Drug Delivery in Tumors" -- "3.1 Outline of Our Approach" -- "3.2 The Image-Based microPK/PD Model" -- "3.3 microPK/PD Model Calibration" -- "3.4 microPK/PD Predictions of Improved Drug Efficacy" -- "4 In Silico Organoid Models for Personalized Medicine" -- "5 Discussion" -- " Appendix A: Mathematical Framework of the IBCell Model" -- " Appendix B: Mathematical Framework of the microPK/PD Model
    Additional Edition: 9783319605098
    Additional Edition: Print version Soker, Shay Tumor Organoids Cham : Springer International Publishing,c2017 9783319605098
    Language: English
    URL: Volltext  (lizenzpflichtig)
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  • 6
    Online Resource
    Online Resource
    Tumor organoids (2018)
    Cham, Switzerland : Humana Press
    Details
    UID:
    (DE-627)1656967081
    Format: 1 Online-Ressource (XVI, 213 Seiten) , Illustrationen, Diagramme
    ISBN: 9783319605111
    Series Statement: Cancer Drug Discovery and Development
    Content: Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell-cell, cell-ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies
    Content: Techniques to Produce and Culture Lung Tumor Organoids -- Tissue Organoids: Liver -- Mammary Gland Organoids -- Biofabrication Technologies for Developing In Vitro Tumor Models -- Three Dimensional In Vitro Tumor Platforms for Cancer Discovery -- Tissue-engineered models for studies of bone metastasis -- Building Better Tumor Models: Organoid Systems to Investigate Angiogenesis -- Microfluidics in cell and tissue studies -- Stiffness-tuned matrices for tumor cell studies -- Mathematical modeling of tumor organoids: toward personalized medicine
    Additional Edition: 9783319605098
    Additional Edition: Erscheint auch als Druck-Ausgabe 978-3-319-60509-8
    Language: English
    DOI: 10.1007/978-3-319-60511-1
    URL: Volltext  (lizenzpflichtig)
    URL: Cover
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  • 7
    Online Resource
    Online Resource
    Tumor Organoids (2018)
    Cham : Springer International Publishing
    Details
    UID:
    (DE-101)1142235327
    Format: Online-Ressourcen
    Edition: 1st edition 2018
    ISBN: 9783319605111
    Series Statement: Cancer Drug Discovery and Development
    Note: Lizenzpflichtig
    Additional Edition: Erscheint auch als Druck-Ausgabe Tumor Organoids Cham : Springer International Publishing, 2017
    Language: German
    DOI: 10.1007/978-3-319-60511-1
    URN: urn:nbn:de:1111-20171025413
    URL: https://doi.org/10.1007/978-3-319-60511-1
    URL: https://nbn-resolving.org/urn:nbn:de:1111-20171025413
    URL: https://d-nb.info/1142235327/34
    URL: http://www.springerlink.com/content/978-3-319-60511-1
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  • 8
    Online Resource
    Online Resource
    Tumor organoids (2018)
    Cham : Humana Press
    Details
    UID:
    (DE-605)HT019504326
    Format: 1 Online-Ressource (xvi, 213 Seiten) , Illustrationen
    ISBN: 9783319605111
    Series Statement: Cancer drug discovery and development
    Additional Edition: Erscheint auch als Druck-Ausgabe 9783319605098
    Language: English
    DOI: 10.1007/978-3-319-60511-1
    URL: http://www.springer.com/
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  • 9
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    Online Resource
    Regenerative medicine applications in organ transplantation (2014)
    Amsterdam : Elsevier/AP
    Details
    UID:
    (DE-627)1655036815
    Format: Online Ressource (xxxvii, 1011 pages) , illustrations (some color)
    ISBN: 9780123985200 , 012398520X , 0123985234 , 9780123985231
    Content: Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more
    Note: Includes bibliographical references and index. - Print version record
    Additional Edition: 0123985234
    Additional Edition: 012398520X
    Additional Edition: Erscheint auch als Druck-Ausgabe Orlando, Giuseppe Regenerative Medicine Applications in Organ Transplantation Burlington : Elsevier Science,c2013 9780123985231
    Language: English
    Keywords: Electronic books ; Electronic books
    URL: Volltext  (lizenzpflichtig)
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  • 10
    Online Resource
    Online Resource
    Regenerative medicine applications in organ transplantation (2014)
    Amsterdam : Elsevier
    Details
    UID:
    (DE-605)HT019790627
    Format: 1 Online-Ressource (xxxvii, 1011 pages)
    Edition: First edition
    ISBN: 9780123985200 , 012398520X
    Note: Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more , Includes bibliographical references and index
    Additional Edition: Erscheint auch als Druck-Ausgabe Orlando, Giuseppe Regenerative medicine applications in organ transplantation 9780123985231
    Language: English
    URL: Volltext
    URL: https://doi.org/10.1016/C2012-0-00629-1
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