Format:
Online-Ressource
ISSN:
1521-3773
Content:
Abstract: Nanographene, a small piece of graphene, has attracted unprecedented interest across diverse scientific disciplines particularly in organic electronics. The biological applications of nanographenes, such as bioimaging, cancer therapies and drug delivery, provide significant opportunities for breakthroughs in the field. However, the intrinsic aggregation behavior and low solubility of nanographenes, which stem from their flat structures, hamper their development for bioapplications. Herein, we report a water‐soluble warped nanographene (WNG) that can be easily synthesized by sequential regioselective C−H borylation and cross‐coupling reactions of the saddle‐shaped WNG core structure. The saddle‐shaped structure and hydrophilic tetraethylene glycol chains impart high water solubility to the WNG. The water‐soluble WNG possesses a range of promising properties including good photostability and low cytotoxicity. Moreover, the water‐soluble WNG was successfully internalized into HeLa cells and promoted photoinduced cell death.
In:
volume:57
In:
number:11
In:
year:2018
In:
pages:2874-2878
In:
extent:5
In:
Angewandte Chemie / International edition, Weinheim : Wiley-VCH, 1962-, 57, Heft 11 (2018), 2874-2878 (gesamt 5), 1521-3773
Language:
English
DOI:
10.1002/anie.201713387
URN:
urn:nbn:de:101:1-2022083105553520147311
URL:
https://doi.org/10.1002/anie.201713387
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2022083105553520147311
URL:
https://d-nb.info/1266729941/34
URL:
https://doi.org/10.1002/anie.201713387
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