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Environmental Impacts on Male Reproductive Development: Lessons from Experimental Models (2021)

Jorgensen, Anne [Verfasser] ; Svingen, Terje [Verfasser] ; Miles, Harriet [Verfasser] ; [et al.]

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UID:

(DE-101)1293483257

Format: Online-Ressource

ISSN: 1663-2826

Content: Background: Male reproductive development in mammals can be divided into a gonadal formation phase followed by a hormone-driven differentiation phase. Failure of these processes may result in Differences in Sex Development (DSD), which may include abnormalities of the male reproductive tract, including cryptorchidism, hypospadias, infertility, and testicular germ cell cancer (TGCC). These disorders are also considered to be part of a testicular dysgenesis syndrome (TDS) in males. Whilst DSDs are considered to result primarily from genetic abnormalities, the development of TDS disorders is frequently associated with environmental factors. Summary: In this review, we will discuss the development of the male reproductive system in relation to DSD and TDS. We will also describe the experimental systems, including studies involving animals and human tissues or cells that can be used to investigate the role of environmental factors in inducing male reproductive disorders. We will discuss recent studies investigating the impact of environmental chemicals (e.g., phthalates and bisphenols), lifestyle factors (e.g., smoking) and pharmaceuticals (e.g., analgesics) on foetal testis development. Finally, we will describe the evidence, involving experimental and epidemiologic approaches, for a role of environmental factors in the development of specific male reproductive disorders, including cryptorchidism, hypospadias, and TGCC. Key Messages: Environmental exposures can impact the development and function of the male reproductive system in humans. Epidemiology studies and experimental approaches using human tissues are important to translate findings from animal studies and account for species differences in response to environmental exposures.

In: volume:96

In: number:2

In: year:2023

In: pages:190-206

In: extent:17

In: Hormone research in paediatrics, Basel : Karger, 2010-, 96, Heft 2 (2023), 190-206 (gesamt 17), 1663-2826

Language: English

DOI: 10.1159/000519964

URN: urn:nbn:de:101:1-2023062200584571366846

URL: https://doi.org/10.1159/000519964

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023062200584571366846

URL: https://d-nb.info/1293483257/34

URL: https://karger.com/doi/10.1159/000519964

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Expansion of the Ago gene family in the teleost clade (2011)

McFarlane, Lindsey [Verfasser] ; Svingen, Terje [Verfasser] ; Braasch, Ingo [Verfasser] ; [et al.]

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UID:

(DE-101)1191824160

Format: Online-Ressource , online resource.

ISSN: 1432-041X , 1432-041X

In: volume:221

In: number:2

In: day:11

In: month:5

In: year:2011

In: pages:95-104

In: date:6.2011

In: Development genes and evolution, Berlin ; Heidelberg : Springer, 1894-, 221, Heft 2 (11.5.2011), 95-104, 6.2011, 1432-041X

Language: English

DOI: 10.1007/s00427-011-0363-7

URN: urn:nbn:de:101:1-2019073021584352198114

URL: https://doi.org/10.1007/s00427-011-0363-7

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2019073021584352198114

URL: https://d-nb.info/1191824160/34

URL: https://doi.org/10.1007/s00427-011-0363-7

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Anogenital distance as a toxicological or clinical marker for fetal androgen action and risk for reproductive disorders (2018)

Schwartz, Camilla Lindgren [Verfasser] ; Christiansen, Sofie [Verfasser] ; Vinggaard, Anne Marie [Verfasser] ; [et al.]

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UID:

(DE-101)1174534435

Format: Online-Ressource , online resource.

ISSN: 1432-0738 , 1432-0738

In: day:14

In: month:11

In: year:2018

In: pages:1-20

In: Archives of toxicology, Berlin ; Heidelberg : Springer, 1930-, (14.11.2018), 1-20, 1432-0738

Language: English

DOI: 10.1007/s00204-018-2350-5

URN: urn:nbn:de:101:1-2018123019290618710275

URL: https://doi.org/10.1007/s00204-018-2350-5

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2018123019290618710275

URL: https://d-nb.info/1174534435/34

URL: https://doi.org/10.1007/s00204-018-2350-5

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Effects on metabolic parameters in young rats born with low birth weight after exposure to a mixture of pesticides (2017)

Svingen, Terje [Verfasser] ; Ramhøj, Louise [Sonstige] ; Mandrup, Karen [Sonstige] ; [et al.]

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UID:

(DE-101)1155542517

Format: Online-Ressource , online resource.

ISSN: 2045-2322 , 2045-2322

In: volume:8

In: number:1

In: day:10

In: month:1

In: year:2018

In: pages:1-10

In: date:12.2018

In: Scientific reports, [London] : Macmillan Publishers Limited, part of Springer Nature, 2011-, 8, Heft 1 (10.1.2018), 1-10, 12.2018, 2045-2322

Language: English

DOI: 10.1038/s41598-017-18626-x

URN: urn:nbn:de:1111-201804058805

URL: https://doi.org/10.1038/s41598-017-18626-x

URL: https://nbn-resolving.org/urn:nbn:de:1111-201804058805

URL: https://d-nb.info/1155542517/34

URL: http://dx.doi.org/10.1038/s41598-017-18626-x

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Calretinin is a novel candidate marker for adverse ovarian effects of early life exposure to mixtures of endocrine disruptors in the rat (2020)

Johansson, Hanna Katarina Lilith [Verfasser] ; Svingen, Terje [Verfasser] ; Boberg, Julie [Verfasser] ; [et al.]

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UID:

(DE-101)1214056970

Format: Online-Ressource , online resource.

ISSN: 1432-0738 , 1432-0738

In: volume:94

In: number:4

In: day:27

In: month:3

In: year:2020

In: pages:1241-1250

In: date:4.2020

In: Archives of toxicology, Berlin ; Heidelberg : Springer, 1930-, 94, Heft 4 (27.3.2020), 1241-1250, 4.2020, 1432-0738

Language: English

DOI: 10.1007/s00204-020-02697-3

URN: urn:nbn:de:101:1-2020071805004330359267

URL: https://doi.org/10.1007/s00204-020-02697-3

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2020071805004330359267

URL: https://d-nb.info/1214056970/34

URL: https://doi.org/10.1007/s00204-020-02697-3

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Functional Analysis of Mmd2 and Related PAQR Genes During Sex Determination in Mice (2022)

Zhao, Liang [Verfasser] ; Thomson, Ella [Verfasser] ; Ng, Ee T. [Verfasser] ; [et al.]

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UID:

(DE-101)1281709425

Format: Online-Ressource

ISSN: 1661-5433

Content: Introduction: Sex determination in eutherian mammals is controlled by the Y-linked gene Sry, which drives the formation of testes in male embryos. Despite extensive study, the genetic steps linking Sry action and male sex determination remain largely unknown. Here, we focused on Mmd2, a gene that encodes a member of the progestin and adipoQ receptor (PAQR) family. Mmd2 is expressed during the sex-determining period in XY but not XX gonads, suggesting a specific role in testis development. Methods: We used CRISPR to generate mouse strains deficient in Mmd2 and its 2 closely related PAQR family members, Mmd and Paqr8, which are also expressed during testis development. Following characterization of Mmd2 expression in the developing testis, we studied sex determination in embryos from single knockout as well as Mmd2;Mmd and Mmd2;Paqr8 double knockout lines using quantitative RT-PCR and immunofluorescence. Results: Analysis of knockout mice deficient in Sox9 and Nr5a1 revealed that Mmd2 operates downstream of these known sex-determining genes. However, fetal testis development progressed normally in Mmd2-null embryos. To determine if other genes might have compensated for the loss of Mmd2, we analyzed Paqr8 and Mmd-null embryos and confirmed that in both knockout lines, sex determination occurred normally. Finally, we generated Mmd2;Mmd and Mmd2;Paqr8 double-null embryos and again observed normal testis development. Discussion: These results may reflect functional redundancy among PAQR factors, or their dispensability in gonadal development. Our findings highlight the difficulties involved in identifying genes with a functional role in sex determination and gonadal development through expression screening and loss-of-function analyses of individual candidate genes and may help to explain the paucity of genes in which variations have been found to cause human disorders/differences of sex development.

In: volume:16

In: number:4

In: year:2023

In: pages:270-282

In: extent:13

In: Sexual development, Basel : Karger, 2007-, 16, Heft 4 (2023), 270-282 (gesamt 13), 1661-5433

Language: English

DOI: 10.1159/000522668

URN: urn:nbn:de:101:1-2023022223133887692246

URL: https://doi.org/10.1159/000522668

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023022223133887692246

URL: https://d-nb.info/1281709425/34

URL: https://www.karger.com/Article/Pdf/522668

URL: https://www.karger.com/Article/FullText/522668

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Fibrinogen and Neopterin Is Associated with Future Myocardial Infarction and Total Mortality in Patients with Stable Coronary Artery Disease (2018)

Mjelva, Øistein Rønneberg [Mitwirkender] ; Svingen, Gard F.T. [Mitwirkender] ; Pedersen, Eva K.R. [Mitwirkender] ; [et al.]

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UID:

(DE-101)1171093381

Format: Online-Ressource

ISSN: 2567-689X

In: volume:118

In: number:04

In: year:2018

In: pages:778-790

In: Thrombosis and haemostasis, Stuttgart : Thieme, 1976-, 118, Heft 04 (2018), 778-790, 2567-689X

Language: English

DOI: 10.1055/s-0038-1629912

URN: urn:nbn:de:101:1-2018111106365767223817

URL: https://doi.org/10.1055/s-0038-1629912

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2018111106365767223817

URL: https://d-nb.info/1171093381/34

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Expression pattern of clinically relevant markers in paediatric germ cell- and sex-cord stromal tumours is similar to adult testicular tumours (2014)

Mosbech, Christiane Hammershaimb [Verfasser] ; Svingen, Terje [Verfasser] ; Nielsen, John Erik [Verfasser] ; [et al.]

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UID:

(DE-101)1189559056

Format: Online-Ressource , online resource.

ISSN: 1432-2307 , 1432-2307

In: volume:465

In: number:5

In: day:30

In: month:7

In: year:2014

In: pages:567-577

In: date:11.2014

In: Virchows Archiv, Berlin ; Heidelberg : Springer, 1847-, 465, Heft 5 (30.7.2014), 567-577, 11.2014, 1432-2307

Language: English

DOI: 10.1007/s00428-014-1635-1

URN: urn:nbn:de:101:1-2019063017332791846057

URL: https://doi.org/10.1007/s00428-014-1635-1

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2019063017332791846057

URL: https://d-nb.info/1189559056/34

URL: https://doi.org/10.1007/s00428-014-1635-1

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Transcriptional profiling of the developing rat ovary following intrauterine exposure to the endocrine disruptors diethylstilbestrol and ketoconazole (2023)

Kugathas, Indusha [Verfasser] ; Johansson, Hanna K. L. [Verfasser] ; Chan Sock Peng, Edith [Verfasser] ; [et al.]

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UID:

(DE-101)1305648951

Format: Online-Ressource, 1 online resource.

ISSN: 1432-0738

In: volume:97

In: number:3

In: day:18

In: month:1

In: year:2023

In: pages:849-863

In: date:3.2023

In: Archives of toxicology, Berlin ; Heidelberg : Springer, 1930-, 97, Heft 3 (18.1.2023), 849-863, 3.2023, 1432-0738

Language: English

DOI: 10.1007/s00204-023-03442-2

URN: urn:nbn:de:101:1-2023101109384797462421

URL: https://doi.org/10.1007/s00204-023-03442-2

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2023101109384797462421

URL: https://d-nb.info/1305648951/34

URL: https://doi.org/10.1007/s00204-023-03442-2

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Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals (2020)

Johansson, Hanna K. L. [Verfasser] ; Damdimopoulou, Pauliina [Verfasser] ; Duursen, Majorie B. M. van [Verfasser] ; [et al.]

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UID:

(DE-101)1221026321

Format: Online-Ressource , online resource.

ISSN: 1432-0738 , 1432-0738

In: volume:94

In: number:10

In: day:7

In: month:7

In: year:2020

In: pages:3359-3379

In: date:10.2020

In: Archives of toxicology, Berlin ; Heidelberg : Springer, 1930-, 94, Heft 10 (7.7.2020), 3359-3379, 10.2020, 1432-0738

Language: English

DOI: 10.1007/s00204-020-02834-y

URN: urn:nbn:de:101:1-2020110812375276197434

URL: https://doi.org/10.1007/s00204-020-02834-y

URL: https://nbn-resolving.org/urn:nbn:de:101:1-2020110812375276197434

URL: https://d-nb.info/1221026321/34

URL: https://doi.org/10.1007/s00204-020-02834-y

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