ISSN:
1466-1861
Content:
A pleiotropic signaling lipid, sphingosine-1-phosphate (S1P), has been implicated in various pathophysiological processes supporting tumor growth and metastasis. However, there are only a few descriptive studies suggesting a role of S1P in tumor lymphangiogenesis, which is critical for tumor growth and dissemination. Corroborating own data, the literature suggests that apoptotic tumor cell-derived S1P alters the phenotype of tumor-associated macrophages (TAMs) to gain protumor functions. However, mechanistically, the role of TAM-induced lymphangiogenesis has only been poorly described, mostly linked to the production of lymphangiogenic factors such as vascular endothelial growth factor C (VEGF-C) and VEGF-D, or transdifferentiation into lymphatic endothelial cells. Recent findings highlight a rather underappreciated role of S1P in tumor lymphangiogenesis, referring to the production of interleukin-1β (IL-1β) and lipocalin-2 (LCN2) by a tumor-promoting macrophage phenotype. In this review, we aim to provide to the readers with the current understanding of the molecular mechanism how apoptotic cell-derived S1P triggers TAMs to promote lymphangiogenesis.
In:
Mediators of inflammation, Sylvania, Ohio : Hindawi Publishing Corp., 1992-, Band 26 (2017), Seite 1-12, Artikel-ID: 7510496, 1466-1861
In:
volume:26
In:
year:2017
In:
pages:1-12
In:
extent:12
In:
elocationid:7510496
Language:
English
DOI:
10.1155/2017/7510496
URN:
urn:nbn:de:hebis:30:3-463524
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