Format:
Online-Ressource
ISSN:
1521-3765
Content:
Abstract: Cyclometalated iridium complexes are found to be versatile catalysts for the direct reductive amination (DRA) of carbonyls to give primary amines under transfer‐hydrogenation conditions with ammonium formate as both the nitrogen and hydrogen source. These complexes are easy to synthesise and their ligands can be easily tuned. The activity and chemoselectivity of the catalyst towards primary amines is excellent, with a substrate to catalyst ratio (S/C) of 1000 being feasible. Both aromatic and aliphatic primary amines were obtained in high yields. Moreover, a first example of homogeneously catalysed transfer‐hydrogenative DRA has been realised for β‐keto ethers, leading to the corresponding β‐amino ethers. In addition, non‐natural α‐amino acids could also be obtained in excellent yields with this method.
In:
volume:20
In:
number:1
In:
year:2013
In:
pages:245-252
In:
extent:8
In:
Chemistry - a European journal, Weinheim : Wiley-VCH, 1995-, 20, Heft 1 (2013), 245-252 (gesamt 8), 1521-3765
Language:
English
DOI:
10.1002/chem.201303541
URN:
urn:nbn:de:101:1-2023010705020900002437
URL:
https://doi.org/10.1002/chem.201303541
URL:
https://nbn-resolving.org/urn:nbn:de:101:1-2023010705020900002437
URL:
https://d-nb.info/1277432570/34
URL:
https://doi.org/10.1002/chem.201303541
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