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  • 1
    UID:
    (DE-603)333899202
    Format: V, 116 S. , graph. Darst.
    Note: Frankfurt (Main), Univ., Diss., 2013
    Language: German
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  • 2
    UID:
    (DE-627)1803868813
    Content: The failing heart is characterized by blunted B-adrenoceptor (B-AR) responses associated with a number of changes in the signal transduction pathway including downregulation of B-ARs, increased expression of inhibitory G-proteins and G-protein coupled receptor kinases (GRKs) and impaired adenylyl cyclase (AC) activities. However, a careful review of the literature reveals that most types of heart failure in human and experimental models used to study B-AR signaling are associated with low cardiac output heart failure with significant fibrosis in the myocardium. No information is available regarding the regulation of B-AR signal transduction in heart failure with a high-output status without fibrosis. Therefore, the objective of this work is to use a high-output heart failure model without fibrosis and examine the status of B-AR signaling. To reach this aim, we first characterized a high-output model induced by an aortocaval shunt from several aspects including general features, morphology and histology of the heart, circulatory congestion, hemodynamics and contractile function in vivo and in vitro. The results demonstrated that the development of hypertrophy and heart failure typically occurred in three stages: developing hypertrophic stage (first two weeks after the induction of shunt), established hypertrophic stage (2-8 weeks) and decompensated hypertrophic or failing stage (8-16 weeks). The failing stage is characterized by dramatic hypertrophy of both left (LV) and right (RV) ventricles with signs of circulatory congestion, decreased in vivo and in vitro cardiac performance and shift of myosin heavy chain isoforms. However, the response of the failing heart to B-AR stimulation was not blunted but instead showed stimulation of contractile function. To investigate the mechanisms underlying the enhanced B-AR response in aortocaval shunted animals, we examined changes at the receptor level. Agonist binding experiments showed a selective increase in density of B 1-AR but not B2-AR, without any changes in the affinities. Western blot experiments confirmed that the increase in B1-AR density is due to an enhanced expression of protein levels rather than an increased externalization of receptors. However, the steady state mRNA level of B1-AR was not altered indicating an increased translational rate or decreased protein degradation underlying the increased B 1-AR protein expression.
    Note: Dissertation 2000
    Language: English
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  • 3
    UID:
    (DE-627)1806915650
    ISSN: 1752-1289
    In: International journal of Chinese culture and management, Olney : Inderscience, 2007, 5(2022), 2, Seite 101-113, 1752-1289
    In: volume:5
    In: year:2022
    In: number:2
    In: pages:101-113
    Language: English
    Keywords: Aufsatz in Zeitschrift
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  • 4
    UID:
    (DE-627)1190535319
    Format: S. 1126 - 1144
    In: Rule of law and harmony of international society ; 2, [Washington, D.C.] : [World Jurist Association], 2005, 2(2005), Seite 1126 - 1144
    In: volume:2
    In: year:2005
    In: pages:1126 - 1144
    Language: English
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  • 5
    Book
    Book
    Athens [u.a.] : Univ. of Georgia Press
    UID:
    (DE-603)057674817
    Format: XXV, 411 S. , Ill.
    ISBN: 082031837X
    Series Statement: Studies in the legal history of the South
    Language: English
    Subjects: History , Law
    RVK:
    RVK:
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  • 6
    Online Resource
    Online Resource
    Athens : University of Georgia Press
    UID:
    (DE-602)gbv_1696738555
    Format: 1 online resource (454 pages)
    ISBN: 9780820342061
    Series Statement: Studies in the Legal History of the South
    Content: Cover -- Contents -- List of Tables -- Preface -- Introduction -- Chapter One. The Road to the Fifteenth Amendment, 1860-1870 -- Chapter Two. The Making of Federal Enforcement Laws, 1870-1872 -- Chapter Three. The Anatomy of Enforcement, 1870-1876 -- Chapter Four. The Hayes Administration and Black Suffrage, 1876-1880 -- Chapter Five. The Survival of a Principle, 1880-1888 -- Chapter Six. The Rise and Fall of Reenforcement, 1888-1891 -- Epilogue. Equality Deferred, 1892-1910 -- Appendix One. Enforcement Act of May 31, 1870 -- Appendix Two. Naturalization Act of July 14, 1870 -- Appendix Three. Enforcement Act of February 28, 1871 -- Appendix Four. Enforcement Act of April 20, 1871 -- Appendix Five. Enforcement Rider in the Civil Appropriation Act of June 10, 1872 -- Appendix Six. Sections from the Enforcement Acts in the Revised Statutes, Their Repeals, and Amendments -- Appendix Seven. Criminal Prosecutions under Enforcement Acts, 1870-1894, by Section and Year -- Appendix Eight. Strength Distribution of the Major Parties in the Federal Government, 1861-1909 -- Abbreviations -- Notes -- Selected Bibliography -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Y.
    Note: Description based on publisher supplied metadata and other sources
    Additional Edition: ISBN 9780820318370
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9780820318370
    Language: English
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  • 7
    UID:
    (DE-604)BV045346324
    Format: xx, 233 Seiten
    ISBN: 9781498514309 , 1498514308 , 9781498514316 , 1498514316
    Series Statement: Emerging perspectives on education in China
    Language: English
    Subjects: General works
    RVK:
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  • 8
    Online Resource
    Online Resource
    Athens [Ga.] :University of Georgia Press, | ©1997
    UID:
    (DE-602)almafu_9959227269302883
    Format: 1 online resource (xxv, 411 pages) : , illustrations.
    Edition: 1st ed.
    ISBN: 1-283-61287-9 , 9786613925329 , 0-8203-4206-8
    Series Statement: Studies in the legal history of the South
    Content: Following the Civil War, Republicans teamed with activist African Americans to protect Black voting rights through constitutional reform. This work looks at the forces and mechanisms which led to Black suffrage, and follows the issues into the early 20th century.
    Note: Bibliographic Level Mode of Issuance: Monograph , Cover -- Contents -- List of Tables -- Preface -- Introduction -- Chapter One. The Road to the Fifteenth Amendment, 1860-1870 -- Chapter Two. The Making of Federal Enforcement Laws, 1870-1872 -- Chapter Three. The Anatomy of Enforcement, 1870-1876 -- Chapter Four. The Hayes Administration and Black Suffrage, 1876-1880 -- Chapter Five. The Survival of a Principle, 1880-1888 -- Chapter Six. The Rise and Fall of Reenforcement, 1888-1891 -- Epilogue. Equality Deferred, 1892-1910 -- Appendix One. Enforcement Act of May 31, 1870 -- Appendix Two. Naturalization Act of July 14, 1870 -- Appendix Three. Enforcement Act of February 28, 1871 -- Appendix Four. Enforcement Act of April 20, 1871 -- Appendix Five. Enforcement Rider in the Civil Appropriation Act of June 10, 1872 -- Appendix Six. Sections from the Enforcement Acts in the Revised Statutes, Their Repeals, and Amendments -- Appendix Seven. Criminal Prosecutions under Enforcement Acts, 1870-1894, by Section and Year -- Appendix Eight. Strength Distribution of the Major Parties in the Federal Government, 1861-1909 -- Abbreviations -- Notes -- Selected Bibliography -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- J -- K -- L -- M -- N -- O -- P -- Q -- R -- S -- T -- U -- V -- W -- Y. , English
    Additional Edition: ISBN 0-8203-1837-X
    Language: English
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  • 9
    Online Resource
    Online Resource
    Kassel : Univ.-Bibliothek
    UID:
    (DE-603)347995942
    Format: Online Ressource
    Note: 4 Fotos des Künstlerbuchs 75 Kun KBS 249. - 4 Hefte, überwiegend Illustrationen. Malerei, Video, Installation, Skulpturen. - Papierart: recycled paper. Satz, Druckverfahren: Digitaldruck. Bindung: saddle stitch. Schrift: Courier.
    Language: Undetermined
    Keywords: Künstlerbuch
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  • 10
    Image
    Image
    [Kassel]
    UID:
    (DE-603)340228563
    Format: 4 Hefte , Illustrationen
    Note: Enthält Malerei, Video, Installation, Skulpturen
    Language: German
    Keywords: Künstlerbuch
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