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,
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Content:
Herzinsuffizienz, Zellmigration, Vorläuferzelle, kardiale Progenitorzellen, Sekretom, Renin-Angiotensin-Aldosteron System, parakrine Wirkungsweisen
Content:
Heart failure is a leading cause of morbidity and mortality worldwide and heart transplantation remains the only therapy for advanced heart failure at this moment. Cell- based therapies involving cardiac stem cells constitute a promising new therapy option for the replacement of lost tissue and the restoration of cardiac function by induction of new vessel formation. Cardiac stem cells exhibit the ability for self-renewal, proliferation and differentiation into specialized cell types and therefore are thought to have a great regenerative potential. Despite the observed beneficial effects after stem cell transplantation e.g. after myocardial infarction, the mechanisms by which the stem cells led to an improvement are still under debate. Furthermore, the influence of the surrounding milieu following injury on stem cell fate and function has to be elucidated. The present work investigated the behavior and function of murine resident cardiac progenitor cells, positive for the surface marker stem cell antigen-1 (Sca-1+), under physiological and pathophysiological conditions. For this purpose we investigated the influence of the renin-angiotensin-aldosterone system, which is a crucial mediator in progression of heart failure, on the function of Sca-1+ cells in vitro. Afterwards, the role of pathophysiological aldosterone concentrations on the secretory activity of Sca-1+ cells was determined. The present work showed for the first time an influence of the components of the ...
Note:
Greifswald, Univ., Diss., 2014
Additional Edition:
Druckausg. Wenzel, Kristin Einfluss des Renin-Angiotensin-Aldosteron Systems auf die Migration und die parakrine Aktivität residenter kardialer Stammzellen 2014
Language:
German
Keywords:
Herzinsuffizienz
;
Zellmigration
;
Vorläuferzelle
;
Herzmuskelzelle
;
Plesiokrinie
;
Renin-Angiotensin-System
;
Hochschulschrift
URN:
urn:nbn:de:gbv:9-002051-9
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