Format:
Online Ressource (148 S., 9.773 KB)
,
Ill., graph. Darst
Content:
miRNAs are tiny regulatory RNAs of 20-25 nucleotides (nt) in length that are endogenously expressed in cells. Hundreds of miRNA genes have been identified in plants and animals. Together they form a large family of regulatory molecules that control important cellular and developmental pathways. Most animal miRNAs regulate the translation of different cellular mRNAs via imperfect base pairing interactions. Due to the complexity of target mRNA recognition only a small subset of miRNAs is annotated with biological functions. In order to contribute to their functional identification, I identified the temporal and spatial expression pattern of D. melanogaster miRNAs by Northern blot analysis at different developmental stages. Temporal expression patterns of miRNAs can be used for the verification of predicted miRNA targets and biological functions. Tissue specific expression patterns of M. musculus miRNAs were identified again by northern blot analysis ...
Note:
Göttingen, Univ., Diss., 2007
Language:
English
Keywords:
Hochschulschrift
URN:
urn:nbn:de:gbv:7-webdoc-1402-1
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