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  • 1
    UID:
    (DE-603)283995483
    Format: 637 S.
    ISBN: 3426770784
    Language: German
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  • 2
    Online Resource
    Online Resource
    Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg
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    UID:
    (DE-603)467144966
    ISSN: 1932-6203
    Content: Introduction: Esophageal atresia with or without tracheoesophageal fistula (EA/TEF) occurs approximately 1 in 3.500 live births representing the most common malformation of the upper digestive tract. Only half a century ago, EA/TEF was fatal among affected newborns suggesting that the steady birth prevalence might in parts be due to mutational de novo events in genes involved in foregut development. Methods: To identify mutational de novo events in EA/TEF patients, we surveyed the exome of 30 case-parent trios. Identified and confirmed de novo variants were prioritized using in silico prediction tools. To investigate the embryonic role of genes harboring prioritized de novo variants we performed targeted analysis of mouse transcriptome data of esophageal tissue obtained at the embryonic day (E) E8.5, E12.5, and postnatal. Results: In total we prioritized 14 novel de novo variants in 14 different genes (APOL2, EEF1D, CHD7, FANCB, GGT6, KIAA0556, NFX1, NPR2, PIGC, SLC5A2, TANC2, TRPS1, UBA3, and ZFHX3) and eight rare de novo variants in eight additional genes (CELSR1, CLP1, GPR133, HPS3, MTA3, PLEC, STAB1, and PPIP5K2). Through personal communication during the project, we identified an additional EA/TEF case-parent trio with a rare de novo variant in ZFHX3. In silico prediction analysis of the identified variants and comparative analysis of mouse transcriptome data of esophageal tissue obtained at E8.5, E12.5, and postnatal prioritized CHD7, TRPS1, and ZFHX3 as EA/TEF candidate genes. Re-sequencing of ZFHX3 in additional 192 EA/TEF patients did not identify further putative EA/TEF-associated variants. Conclusion: Our study suggests that rare mutational de novo events in genes involved in foregut development contribute to the development of EA/TEF.
    In: PLOS ONE, San Francisco, California, US : PLOS, 2006-, Band 15, Heft 6 (2020), Seite 1-14, Artikel-ID: e0234246, 1932-6203
    In: volume:15
    In: year:2020
    In: number:6
    In: pages:1-14
    In: extent:14
    In: elocationid:e0234246
    Language: English
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  • 3
    UID:
    (DE-605)(DE-362)10389430
    Format: 732 Seiten
    Edition: Vollst. Taschenbuchausg., erw. Neuausg.
    ISBN: 3426627051 , 9783426627051
    Series Statement: Knaur 62705
    Language: German
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  • 4
    Book
    Book
    Hammersmith [u.a.] : Flamingo
    UID:
    (DE-605)HT011134146
    Format: 696, [16] S.
    Edition: New ed
    ISBN: 0006374921
    Language: Undetermined
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  • 5
    UID:
    (DE-605)HT015305333
    Format: XXVII, 732 Seiten , Illustrationen, Karte
    Edition: Vollständige Taschenbuchausgabe
    ISBN: 9783426627051 , 3426627051
    Series Statement: Knaur 62705
    Language: German
    Subjects: English Studies
    RVK:
    Keywords: China ; Nonkonformismus ; Frau ; Geschichte ; Fiktionale Darstellung
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  • 6
    UID:
    (DE-605)(DE-380)1325802
    Format: 543 Seiten, 16 Seiten Tafeln , Illustrationen ; 22 cm, 793 g
    Edition: 1. Auflage
    Language: German
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  • 7
    Book
    Book
    London : HarperCollins
    UID:
    (DE-605)HT006663350
    Format: 524 S. : Ill., graph. Darst., Kt.
    ISBN: 0002153572
    Language: English
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  • 8
    UID:
    (DE-101)942595378
    Format: 648, [16] S. , Ill., Kt. , 18 cm
    Edition: Vollst. Sonderausg.
    ISBN: 9783426609989 , 3426609983
    Series Statement: Knaur 60998
    Language: German
    Keywords: China ; Nonkonformismus ; Frau ; Geschichte 1909-1978 ; Belletristische Darstellung ; Fiktionale Darstellung ; Belletristische Darstellung
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  • 9
    Book
    Book
    London : Flamingo
    UID:
    (DE-627)124181813
    Format: 696, [16] Seiten , Illustrationen , 18 cm
    ISBN: 0006374921
    Language: English
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  • 10
    UID:
    (DE-627)1727010760
    Format: xx, 374 Seiten, 32 ungezählte Seiten mit Fotos , Illustrationen , 25 cm
    ISBN: 9780525657828 , 9780451493507 , 0451493508
    Content: Part I:The road to the republic (1866-1911).The rise of the father of China --Soong Charlie: a methodist preacher and a secret revolutionary --Part II:The sisters and Sun Yat-sen (1912-1925).Ei-ling: a 'mighty smart' young lady --China embarks on democracy --The marriages of Ei-ling and Ching-ling --To become Mme Sun --'I wish to follow the example of my friend Lenin' --Part III:The sisters and Chiang Kai-shek (1926-1936) --Shanghai ladies --May-ling meets the Generalissimo --Married to a beleaguered dictator --Ching-ling in exile: Moscow, Berlin, Shanghai --The husband and wife team --Getting Chiang's Son back from Stalin's clutches --'A woman protects a man' --Part IV:The sisters in wars (1937-1950).Bravery and corruption --Red sister's frustration --Little sister's triumph and misery --The downfall of the Chiang regime --Part V:Three women, three destinies (1949-2003).'We must crush warm-feeling-ism': being Mao's vice chairman --'I have no regrets' --Taiwan days --The Hollywood connection --New York, New York --In the face of a changed time.
    Content: They were the most famous sisters in China. As the country battled through a hundred years of wars, revolutions and seismic transformations, the three Soong sisters from Shanghai were at the center of power, and each of them left an indelible mark on history. Red Sister, Ching-ling, married the "Father of China," Sun Yat-sen, and rose to be Mao's vice-chair. Little Sister, May-ling, became Madame Chiang Kai-shek, first lady of pre-Communist Nationalist China and a major political figure in her own right. Big Sister, Ei-ling, became Chiang's unofficial main adviser - and made herself one of China's richest women. All three sisters enjoyed tremendous privilege and glory but also endured constant mortal danger. They showed great courage and experienced passionate love, as well as despair and heartbreak. They remained close emotionally, even when they embraced opposed political camps and Ching-ling dedicated herself to destroying her two sisters' worlds. Big Sister, Little Sister, Red Sister is a gripping story of love, war, intrigue, bravery, glamour and betrayal that takes us on a sweeping journey from Canton to Hawaii to New York, from exiles' quarters in Japan and Berlin to secret meeting rooms in Moscow, and from the compounds of the Communist elite in Beijing to the corridors of power in democratic Taiwan. In a group biography that is by turns intimate and epic, Jung Chang reveals the lives of three extraordinary women who helped shape twentieth-century China. --
    Note: "A Borzoi book." , Includes bibliographical references (pages 341-354) and index
    Language: English
    Keywords: Biographies
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