Umfang:
Online-Ressource
,
v.: digital
Ausgabe:
1st
Ausgabe:
Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences Electronic reproduction; Available via World Wide Web
ISBN:
9781441913999
Serie:
Advances in Experimental Medicine and Biology 664
Inhalt:
This is the proceedings of the XIIIth International Symposium on Retinal Degenerations, which will be held in Emeishan, Sichuan, China on September 18 - 23, 2008. The themes will include "Molecular and genetic mechanisms in photoreceptor degeneration," "Age-related macular degeneration," "New diagnostic techniques for retinal degenerations." "Neuroprotection in the prevention of retinal degeneration," "Gene therapy and the correction of gene defects," as well as other emerging topics that may develop over the next few months
Anmerkung:
"XIII International Symposium on Retinal Degeneration (also known as RD2008) was held from September 18-23, 2008 at the Hong Zhu Shan Hotel at the foot of Ernei Mountain in the Sichuan Province of China, near Chendu."--P. ix
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Includes bibliographical references and index
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Dedication; Dedication; Preface; Contents; Contributors; Travel Awards; About the Editors; Part I Basic Science Underlying Retinal Degeneration; 1 Analysis of Genes Differentially Expressed During Retinal Degeneration in Three Mouse Models; 1.1 Introduction; 1.2 Methods; 1.2.1 RNA Preparation and cDNA Labeling; 1.2.2 Hybridization of Slides, Image Acquisition and Bioinformatics; 1.2.3 Real-Time PCR; 1.3 Results; 1.3.1 Microarray Analysis of Opsin 02550256 0/0 Model; 1.3.2 Microarray Analysis of Bouse C Model; 1.3.3 Microarray Analysis of MOT1 Mouse; 1.4 Discussion; References
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2 Regulation of Angiogenesis by Macrophages2.1 Macrophage Polarization and Its Role in Angiogenesis; References; 3 Protein Kinase C Regulates Rod Photoreceptor Differentiation Through Modulation of STAT3 Signaling; 3.1 Introduction; 3.2 Materials and Methods; 3.2.1 Reagents; 3.2.2 Animals and Retina Explant Culture; 3.2.3 Cell Culture; 3.2.4 Western Blot Assay; 3.3 Results; 3.3.1 Phorbol Esters Increase Rod Generation; 3.3.2 Expression of PKC Isoforms in Developing Retina; 3.3.3 Activation of PKC Decreases Phosphorylation of STAT3; 3.4 Discussion; References
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4 Pigment Epithelium-derived Factor Receptor (PEDF-R): A Plasma Membrane-linked Phospholipase with PEDF Binding Affinity4.1 Introduction; 4.2 Identification of a PEDF Receptor; 4.3 In Silico Information; 4.4 Expression and Distribution in the Retina; 4.5 Transmembrane Topology; 4.6 Binding to PEDF Ligands; 4.7 Phospholipase Activity; 4.8 PEDF-R Activity in Retinal Cells; 4.9 Conclusions; References; 5 The Function of Oligomerization-Incompetent RDS in Rods; References; 6 The Association Between Telomere Length and Sensitivity to Apoptosis of HUVEC; 6.1 Introduction; 6.2 Methods
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6.2.1 The Culture of HUVEC and the Construction of Cell Division Model6.2.2 Construction of an Apoptosis Model of HUVEC with Free Hydroxyl Radicals; 6.2.3 Measurement of Apoptosis Rates and Telomere Lengths; 6.2.4 Statistics Analysis; 6.3 Results; 6.3.1 Relationship Between the Time of Culture and the Telomere Length; 6.3.2 Relationship Among Apoptosis Rates, Culture Times and Oxidation; 6.3.3 Oxidation Enhances the Telomere Shortening; 6.4 Discussion; References; 7 Photoreceptor Guanylate Cyclases and cGMP Phosphodiesterases in Zebrafish
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7.1 Regulation of cGMP Levels in Photoreceptor Outer Segments7.2 Retinal Disorders Associated with Mutations in RetGCs and PDE6; 7.3 Analysis of Teleost RetGC and PDEs in Retinal Function and Disorders; References; 8 RDS in Cones Does Not Interact with the Beta Subunit of the Cyclic Nucleotide Gated Channel; References; 9 Increased Expression of TGF-1 and Smad 4 on Oxygen-Induced Retinopathy in Neonatal Mice; 9.1 Introduction; 9.2 Material and Methods; 9.2.1 Animals; 9.2.2 Methods; 9.2.2.1 TGF- Immunohistochemistry (IH) and Smad-4 In Situ Hybridization (ISH); 9.2.3 Statistical Analysis
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9.3 Results
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Electronic reproduction; Available via World Wide Web
Weitere Ausg.:
ISBN 9781441913982
Sprache:
Englisch
Fachgebiete:
Medizin
Schlagwort(e):
Netzhautdegeneration
;
Chengdu
DOI:
10.1007/978-1-4419-1399-9
URL:
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