UID:
almafu_9961426823702883
Format:
1 videorecording (52 min., 54 sec.)
,
005254
Note:
Retrieved April 12, 2024, from https://hstalks.com/bs/1483/.
,
Introduction -- Concept through proof of concept -- Epidemiological observations -- Methods of investigation in humans -- Mendelian and complex inheritance -- Mendelian genetics -- Invasive pneumococcal disease (IPD) -- Genetic disorders in the NF-KB signaling pathway -- IRAK-4/MyD88 deficiencies -- The genus Mycobacterium -- MSMD -- Gene mutations in MSMD -- IL12R-beta1 deficiency and tuberculosis (TB) -- Mendelian TB proportion in disseminated forms -- Investigation of common infectious diseases -- Tuberculosis and leprosy -- TB: individual variability in response to infection -- Complex TB inheritance: candidate genes -- Complex TB inheritance: major gene -- TB: genome-wide linkage screen -- Linkage to chromosome 8q12-q13 -- Leprosy: response to M. leprae -- Leprosy clinical features -- Leprosy epidemiology -- Countries with increasing incidence -- Difficulties in investigating leprosy -- Leprosy per se -- Leprosy linkage analysis (1) -- Leprosy linkage analysis (2) -- Family-based association study -- Primary scan -- Results of the association study -- Exact replication in the same population (1) -- Exact replication in the same population (2) -- Case-control replication in Northern India (1) -- Case-control replication in Northern India (2) -- LTA+80 A allele effect on leprosy susceptibility -- Case-control replication in Brazil -- LTA+80 A allele effect in the Brazilian population -- Age at leprosy diagnosis -- Performing the analysis by age -- Concluding remarks on leprosy -- Continuous spectrum -- Genetic spectrum depends on age -- Acknowledgements (1) -- Acknowledgements (2) -- Some reviews in the subject.
Language:
English
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