Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (315 p.)

ISBN: 0-12-405533-8

Content: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagy presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases. This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. Volumes in the Series.

Note: Bibliographic Level Mode of Issuance: Monograph , Front Cover -- Autophagy -- Copyright Page -- Dedication -- Mitophagy and Biogenesis -- Contents -- Foreword by Roberta A. Gottlieb -- Foreword by Eeva-Liisa Eskelinen -- Preface -- Contributors -- Abbreviations and Glossary -- Autophagy: Volume 1 - Contributions -- Autophagy: Volume 2 - Contributions -- Autophagy: Volume 3 - Contributions -- 1 Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 4 -- Introduction -- Specific Functions of Autophagy (A Summary) -- Autophagy in Normal Mammalian Cells -- Major Types of Autophagies -- Macroautophagy (Autophagy) -- Microautophagy -- Chaperone-Mediated Autophagy -- Autophagosome Formation -- Autophagic Lysosome Reformation -- Autophagic Proteins -- Protein Degradation Systems -- Beclin 1 -- Non-Autophagic Functions of Autophagy-Related Proteins -- Microtubule-Associated Protein Light Chain 3 -- Monitoring Autophagy -- Reactive Oxygen Species (ROS) -- Mammalian Target of Rapamycin (mTOR) -- Role of Autophagy in Tumorigenesis and Cancer -- Role of Autophagy in Immunity -- Autophagy and Senescence -- Role of Autophagy in Viral Defense and Replication -- Role of Autophagy in Intracellular Bacterial Infection -- Role of Autophagy in Heart Disease -- Role of Autophagy in Neurodegenerative Diseases -- Cross-Talk between Autophagy and Apoptosis -- Autophagy and Ubiquitination -- Aggresome: Ubiquitin Proteasome and Autophagy Systems -- Autophagy and Necroptosis -- Mitochondrial Fusion and Fission -- Selective Autophagies -- Allophagy -- Glycophagy -- Pexophagy -- References -- I: General Applications -- 2 Molecular Process and Physiological Significance of Mitophagy -- Introduction -- Selective Autophagy in Yeast -- Selective Autophagy in Higher Eukaryotes -- Mitochondrial Dysfunction in Age-Related Diseases -- Mitochondrial Quality Control Systems. , Mitophagy in Yeast -- Mitophagy in Mammalian Cells -- BNIP3L and BNIP3 -- FUNDC1 -- PARK2 and PINK1 -- Discussion and Perspectives -- References -- 3 Principles of Mitophagy and Beyond -- Introduction -- Yeast Mitophagy -- Principles and Mechanisms -- The Importance of Mitophagy in Yeast -- Mitophagy in Higher Eukaryotes -- Fundc1 -- NIX and BNIP3 -- Pink1 (and Parkin) -- General Conclusions -- Acknowledgments -- References -- 4 Quality Control in Mitochondria -- Mechanisms of Mitochondrial Quality Control -- Autophagy in S. cerevisiae -- An Overview of Mitophagy in S. cerevisiae -- Additional Mitochondrial Quality Control Mechanisms -- Causes of Mitophagy -- Yeast Proteins Involved in Mitophagy -- ATG Proteins -- MAP Kinases -- Phosphatases -- The RTG (Retrograde) Signaling Pathway and Mitophagy -- Uth1 -- Functional Homologues of Yeast Mitophagy Proteins in Mammals -- Mitochondrial Dynamics and Mitophagy -- Future Directions of Yeast Mitophagy Research -- References -- 5 Mitophagy: An Overview -- Snapshot: Mitophagy -- Molecular Mechanisms and Regulation -- Mitochondrial Dynamics and Mitophagy -- Monitoring Mitophagy -- Physiological and Pathological Roles of Mitophagy -- Development -- Aging -- Cancer -- Neurodegenerative Diseases -- Infection and Inflammation -- Preventive Measures for Mitophagy-Related Diseases -- Future Questions and Concluding Remarks -- Acknowledgments -- References -- II: Molecular Mechanisms -- 6 Mitophagy Induction and Curcumin-Mediated Sonodynamic Chemotherapy -- Introduction -- Alternative Therapeutic Strategies: Ultrasound Therapy and Sonodynamic Chemotherapy -- A Promising Sensitive Drug: Curcumin -- Discussion -- Acknowledgments -- References -- 7 Role of Nix in the Maturation of Erythroid Cells through Mitochondrial Autophagy -- Introduction -- Nix and Mitochondrial Autophagy in Erythroid Differentiation. , Expression of Nix during Terminal Erythroid Differentiation -- Nix Regulates Mitochondrial Autophagy in Reticulocytes -- Nix-Mediated Mitochondrial Clearance Involves Both Atg7-Dependent and Atg7-Independent Autophagy -- Mechanisms of Nix-Mediated Mitochondrial Autophagy -- Nix-Dependent Loss of Mitochondrial Membrane Potential in the Promotion of Mitochondrial Autophagy -- Nix as a Mitochondrial Receptor for Binding to Autophagosome -- Nix Domains Required for Mitochondrial Autophagy -- Conclusions -- Acknowledgments -- References -- 8 Role of the Antioxidant Melatonin in Regulating Autophagy and Mitophagy -- Introduction -- Aging -- Neurodegenerative Diseases -- Cancer -- Conclusions and Perspectives -- References -- 9 Ubiquitin Ligase-Assisted Selective Autophagy of Mitochondria: Determining Its Biological Significance Using Droso ... -- Introduction -- Drosophila Models for Parkinson's Disease -- Mitophagy and Mitochondrial Dynamics -- Muscle Degeneration Caused by Mitochondrial Defects -- Mitophagy and Protein Translation Signaling -- Crosstalk Between Mitophagy Signals and the Ubiquitin-Proteasome Pathway -- Possible Roles of Mitophagy in Neurons -- Regulators of Mitochondrial Maintenance Identified in Drosophila Studies -- Tools for the Detection of Mitophagy in Drosophila -- Concluding Remarks -- References -- 10 Atg32 Confers Selective Mitochondrial Sequestration as a Cargo for Autophagy -- Introduction -- Atg32, a Mitophagy-Specific Protein -- Genome-wide Screen for Mitophagy-Deficient Mutants in Yeast -- Localization and Topology of Atg32 -- Atg32 Interacts with Atg11 for Selective MitochondriaL Degradation -- Atg11, an Adaptor Protein for Selective Autophagy -- Atg32 is a Receptor Protein for Mitophagy that Interacts with Atg11 -- Phosphorylation of Atg32 Mediates Atg32-Atg11 Interactions and Mitophagy -- Atg32 Interacts with Atg8. , Induction and Regulation of Mitophagy -- Mitophagy Induction in Yeast -- Signaling Pathways that Regulate Mitophagy -- Other Factors Related to Mitophagy in Yeast -- Physiological Role of Mitophagy in Yeast -- Acknowledgments -- References -- 11 PARK2 Induces Autophagy Removal of Impaired Mitochondria via Ubiquitination -- Introduction -- Mitochondrial Dysfunction and Parkinson's Disease -- Park2/Parkin and Intracellular Quality Control -- Relevance of Parkin-Mediated Mitophagy to Parkinson's Disease Pathogenesis -- Concluding Remarks -- Acknowledgments -- References -- 12 Ubiquitination of Mitofusins in PINK1/Parkin-Mediated Mitophagy -- Introduction -- Mitochondrial Dynamics -- PINK1/Parkin-Mediated Mitophagy -- Ubiquitination of Mfn1 and Mfn2 by Parkin -- Consequences of Mfn Ubiquitination -- Conclusions and Perspectives -- Acknowledgments -- References -- 13 Mitochondrial Alterations and Mitophagy in Response to 6-Hydroxydopamine -- Introduction -- Mitochondrial Alterations -- Biochemical Mitochondrial Alterations -- Morphological Mitochondrial Alterations -- 6-OHDA and Mitochondrial Dynamics -- 6-OHDA and Autophagy -- Acknowledgments -- References -- III: Role in Disease -- 14 Role of Mitochondrial Fission and Mitophagy in Parkinson's Disease -- Introduction -- Mitochondrial Fission and PD -- Mitophagy -- Genetic Factors -- α-Synuclein -- Leucine-Rich Repeat Kinase 2 -- DJ-1 -- Parkin -- PTEN-Induced Kinase 1 -- Omi/HtrA2 -- Sporadic PD -- References -- 15 Mitophagy Controlled by the PINK1-Parkin Pathway Is Associated with Parkinson's Disease Pathogenesis -- Introduction -- Parkin has Ubiquitin Ligase Activity -- Genetic Association Between the PD Genes PARKIN and PINK1 -- Pink1 and Parkin are Involved in the Regulation of Mitochondrial Dynamics -- Parkin is Involved in the Elimination of Damaged Mitochondria Through the Mitophagy Pathway. , PINK1 Regulates the Mitochondrial Translocation of Parkin -- Molecular Regulation of PINK1 and Parkin -- PINK1 and Parkin Regulate Mitochondrial Motility -- Physiological and Pathological Roles of Mitophagy by the PINK1-Parkin Pathway -- Discussion -- Acknowledgments -- References -- 16 Loss of Mitochondria during Skeletal Muscle Atrophy -- Introduction -- Ubiquitin-Proteasome System Mediated Muscle Atrophy -- Autophagy-Lysosomal System Mediated Muscle Atrophy -- Mitophagy-Mediated Muscle Atrophy -- Mechanisms Underlying the Loss of Mitochondria During Muscle Atrophy -- Conclusion and Future Directions -- References -- 17 Role of Impaired Mitochondrial Autophagy in Cardiac Aging -- Introduction -- Mechanisms and Consequences of Mitochondrial Dysfunction in the Aging Heart -- Mitochondria as a Source of Oxidants -- Mechanisms of Mitochondrial Dysfunction in the Aging Heart -- Consequences of Mitochondrial Dysfunction on Heart Physiology -- Contribution of Impaired Mitochondrial Quality Control to Cardiac Aging -- Role of Altered Mitochondrial Dynamics in Cardiac Aging -- Contribution of Altered Mitochondrial Autophagy to Heart Senescence -- Mitochondrial Dysfunction and Quality Control: Novel Pharmacological Targets Against Cardiac Aging and Cardiovascular Disea ... -- Conclusion -- References -- Index. , English

Additional Edition: ISBN 0-12-405528-1

Additional Edition: ISBN 1-322-01798-0

Language: English

UID:

Format: 1 online resource (315 p.)

ISBN: 0-12-405533-8

Content: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagy presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases. This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. Volumes in the Series.

Note: Bibliographic Level Mode of Issuance: Monograph , Front Cover -- Autophagy -- Copyright Page -- Dedication -- Mitophagy and Biogenesis -- Contents -- Foreword by Roberta A. Gottlieb -- Foreword by Eeva-Liisa Eskelinen -- Preface -- Contributors -- Abbreviations and Glossary -- Autophagy: Volume 1 - Contributions -- Autophagy: Volume 2 - Contributions -- Autophagy: Volume 3 - Contributions -- 1 Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 4 -- Introduction -- Specific Functions of Autophagy (A Summary) -- Autophagy in Normal Mammalian Cells -- Major Types of Autophagies -- Macroautophagy (Autophagy) -- Microautophagy -- Chaperone-Mediated Autophagy -- Autophagosome Formation -- Autophagic Lysosome Reformation -- Autophagic Proteins -- Protein Degradation Systems -- Beclin 1 -- Non-Autophagic Functions of Autophagy-Related Proteins -- Microtubule-Associated Protein Light Chain 3 -- Monitoring Autophagy -- Reactive Oxygen Species (ROS) -- Mammalian Target of Rapamycin (mTOR) -- Role of Autophagy in Tumorigenesis and Cancer -- Role of Autophagy in Immunity -- Autophagy and Senescence -- Role of Autophagy in Viral Defense and Replication -- Role of Autophagy in Intracellular Bacterial Infection -- Role of Autophagy in Heart Disease -- Role of Autophagy in Neurodegenerative Diseases -- Cross-Talk between Autophagy and Apoptosis -- Autophagy and Ubiquitination -- Aggresome: Ubiquitin Proteasome and Autophagy Systems -- Autophagy and Necroptosis -- Mitochondrial Fusion and Fission -- Selective Autophagies -- Allophagy -- Glycophagy -- Pexophagy -- References -- I: General Applications -- 2 Molecular Process and Physiological Significance of Mitophagy -- Introduction -- Selective Autophagy in Yeast -- Selective Autophagy in Higher Eukaryotes -- Mitochondrial Dysfunction in Age-Related Diseases -- Mitochondrial Quality Control Systems. , Mitophagy in Yeast -- Mitophagy in Mammalian Cells -- BNIP3L and BNIP3 -- FUNDC1 -- PARK2 and PINK1 -- Discussion and Perspectives -- References -- 3 Principles of Mitophagy and Beyond -- Introduction -- Yeast Mitophagy -- Principles and Mechanisms -- The Importance of Mitophagy in Yeast -- Mitophagy in Higher Eukaryotes -- Fundc1 -- NIX and BNIP3 -- Pink1 (and Parkin) -- General Conclusions -- Acknowledgments -- References -- 4 Quality Control in Mitochondria -- Mechanisms of Mitochondrial Quality Control -- Autophagy in S. cerevisiae -- An Overview of Mitophagy in S. cerevisiae -- Additional Mitochondrial Quality Control Mechanisms -- Causes of Mitophagy -- Yeast Proteins Involved in Mitophagy -- ATG Proteins -- MAP Kinases -- Phosphatases -- The RTG (Retrograde) Signaling Pathway and Mitophagy -- Uth1 -- Functional Homologues of Yeast Mitophagy Proteins in Mammals -- Mitochondrial Dynamics and Mitophagy -- Future Directions of Yeast Mitophagy Research -- References -- 5 Mitophagy: An Overview -- Snapshot: Mitophagy -- Molecular Mechanisms and Regulation -- Mitochondrial Dynamics and Mitophagy -- Monitoring Mitophagy -- Physiological and Pathological Roles of Mitophagy -- Development -- Aging -- Cancer -- Neurodegenerative Diseases -- Infection and Inflammation -- Preventive Measures for Mitophagy-Related Diseases -- Future Questions and Concluding Remarks -- Acknowledgments -- References -- II: Molecular Mechanisms -- 6 Mitophagy Induction and Curcumin-Mediated Sonodynamic Chemotherapy -- Introduction -- Alternative Therapeutic Strategies: Ultrasound Therapy and Sonodynamic Chemotherapy -- A Promising Sensitive Drug: Curcumin -- Discussion -- Acknowledgments -- References -- 7 Role of Nix in the Maturation of Erythroid Cells through Mitochondrial Autophagy -- Introduction -- Nix and Mitochondrial Autophagy in Erythroid Differentiation. , Expression of Nix during Terminal Erythroid Differentiation -- Nix Regulates Mitochondrial Autophagy in Reticulocytes -- Nix-Mediated Mitochondrial Clearance Involves Both Atg7-Dependent and Atg7-Independent Autophagy -- Mechanisms of Nix-Mediated Mitochondrial Autophagy -- Nix-Dependent Loss of Mitochondrial Membrane Potential in the Promotion of Mitochondrial Autophagy -- Nix as a Mitochondrial Receptor for Binding to Autophagosome -- Nix Domains Required for Mitochondrial Autophagy -- Conclusions -- Acknowledgments -- References -- 8 Role of the Antioxidant Melatonin in Regulating Autophagy and Mitophagy -- Introduction -- Aging -- Neurodegenerative Diseases -- Cancer -- Conclusions and Perspectives -- References -- 9 Ubiquitin Ligase-Assisted Selective Autophagy of Mitochondria: Determining Its Biological Significance Using Droso ... -- Introduction -- Drosophila Models for Parkinson's Disease -- Mitophagy and Mitochondrial Dynamics -- Muscle Degeneration Caused by Mitochondrial Defects -- Mitophagy and Protein Translation Signaling -- Crosstalk Between Mitophagy Signals and the Ubiquitin-Proteasome Pathway -- Possible Roles of Mitophagy in Neurons -- Regulators of Mitochondrial Maintenance Identified in Drosophila Studies -- Tools for the Detection of Mitophagy in Drosophila -- Concluding Remarks -- References -- 10 Atg32 Confers Selective Mitochondrial Sequestration as a Cargo for Autophagy -- Introduction -- Atg32, a Mitophagy-Specific Protein -- Genome-wide Screen for Mitophagy-Deficient Mutants in Yeast -- Localization and Topology of Atg32 -- Atg32 Interacts with Atg11 for Selective MitochondriaL Degradation -- Atg11, an Adaptor Protein for Selective Autophagy -- Atg32 is a Receptor Protein for Mitophagy that Interacts with Atg11 -- Phosphorylation of Atg32 Mediates Atg32-Atg11 Interactions and Mitophagy -- Atg32 Interacts with Atg8. , Induction and Regulation of Mitophagy -- Mitophagy Induction in Yeast -- Signaling Pathways that Regulate Mitophagy -- Other Factors Related to Mitophagy in Yeast -- Physiological Role of Mitophagy in Yeast -- Acknowledgments -- References -- 11 PARK2 Induces Autophagy Removal of Impaired Mitochondria via Ubiquitination -- Introduction -- Mitochondrial Dysfunction and Parkinson's Disease -- Park2/Parkin and Intracellular Quality Control -- Relevance of Parkin-Mediated Mitophagy to Parkinson's Disease Pathogenesis -- Concluding Remarks -- Acknowledgments -- References -- 12 Ubiquitination of Mitofusins in PINK1/Parkin-Mediated Mitophagy -- Introduction -- Mitochondrial Dynamics -- PINK1/Parkin-Mediated Mitophagy -- Ubiquitination of Mfn1 and Mfn2 by Parkin -- Consequences of Mfn Ubiquitination -- Conclusions and Perspectives -- Acknowledgments -- References -- 13 Mitochondrial Alterations and Mitophagy in Response to 6-Hydroxydopamine -- Introduction -- Mitochondrial Alterations -- Biochemical Mitochondrial Alterations -- Morphological Mitochondrial Alterations -- 6-OHDA and Mitochondrial Dynamics -- 6-OHDA and Autophagy -- Acknowledgments -- References -- III: Role in Disease -- 14 Role of Mitochondrial Fission and Mitophagy in Parkinson's Disease -- Introduction -- Mitochondrial Fission and PD -- Mitophagy -- Genetic Factors -- α-Synuclein -- Leucine-Rich Repeat Kinase 2 -- DJ-1 -- Parkin -- PTEN-Induced Kinase 1 -- Omi/HtrA2 -- Sporadic PD -- References -- 15 Mitophagy Controlled by the PINK1-Parkin Pathway Is Associated with Parkinson's Disease Pathogenesis -- Introduction -- Parkin has Ubiquitin Ligase Activity -- Genetic Association Between the PD Genes PARKIN and PINK1 -- Pink1 and Parkin are Involved in the Regulation of Mitochondrial Dynamics -- Parkin is Involved in the Elimination of Damaged Mitochondria Through the Mitophagy Pathway. , PINK1 Regulates the Mitochondrial Translocation of Parkin -- Molecular Regulation of PINK1 and Parkin -- PINK1 and Parkin Regulate Mitochondrial Motility -- Physiological and Pathological Roles of Mitophagy by the PINK1-Parkin Pathway -- Discussion -- Acknowledgments -- References -- 16 Loss of Mitochondria during Skeletal Muscle Atrophy -- Introduction -- Ubiquitin-Proteasome System Mediated Muscle Atrophy -- Autophagy-Lysosomal System Mediated Muscle Atrophy -- Mitophagy-Mediated Muscle Atrophy -- Mechanisms Underlying the Loss of Mitochondria During Muscle Atrophy -- Conclusion and Future Directions -- References -- 17 Role of Impaired Mitochondrial Autophagy in Cardiac Aging -- Introduction -- Mechanisms and Consequences of Mitochondrial Dysfunction in the Aging Heart -- Mitochondria as a Source of Oxidants -- Mechanisms of Mitochondrial Dysfunction in the Aging Heart -- Consequences of Mitochondrial Dysfunction on Heart Physiology -- Contribution of Impaired Mitochondrial Quality Control to Cardiac Aging -- Role of Altered Mitochondrial Dynamics in Cardiac Aging -- Contribution of Altered Mitochondrial Autophagy to Heart Senescence -- Mitochondrial Dysfunction and Quality Control: Novel Pharmacological Targets Against Cardiac Aging and Cardiovascular Disea ... -- Conclusion -- References -- Index. , English

Additional Edition: ISBN 0-12-405528-1

Additional Edition: ISBN 1-322-01798-0

Language: English

UID:

Format: 1 online resource (315 p.)

ISBN: 0-12-405533-8

Content: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volume 4 - Mitophagy presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson's Disease, cardiac aging, and skeletal muscle atrophy. The most current understanding of the proteins and pathways involved in mitophagy are covered, with specific attention to Nix and Bnip3, PINK1/Parkin, Atg32, and FUNDC1. The role of mitophagy in cancer, neurodegeneration, aging, infection, and inflammation is also discussed providing essential insights into the pathogenesis of a variety of mitochondria dysfunction-related diseases. This book is an asset to newcomers as a concise overview of the current knowledge on mitophagy, while serving as an excellent update reference for more experienced scientists working on other aspects of autophagy. From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases. Volumes in the Series.

Note: Bibliographic Level Mode of Issuance: Monograph , Front Cover -- Autophagy -- Copyright Page -- Dedication -- Mitophagy and Biogenesis -- Contents -- Foreword by Roberta A. Gottlieb -- Foreword by Eeva-Liisa Eskelinen -- Preface -- Contributors -- Abbreviations and Glossary -- Autophagy: Volume 1 - Contributions -- Autophagy: Volume 2 - Contributions -- Autophagy: Volume 3 - Contributions -- 1 Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 4 -- Introduction -- Specific Functions of Autophagy (A Summary) -- Autophagy in Normal Mammalian Cells -- Major Types of Autophagies -- Macroautophagy (Autophagy) -- Microautophagy -- Chaperone-Mediated Autophagy -- Autophagosome Formation -- Autophagic Lysosome Reformation -- Autophagic Proteins -- Protein Degradation Systems -- Beclin 1 -- Non-Autophagic Functions of Autophagy-Related Proteins -- Microtubule-Associated Protein Light Chain 3 -- Monitoring Autophagy -- Reactive Oxygen Species (ROS) -- Mammalian Target of Rapamycin (mTOR) -- Role of Autophagy in Tumorigenesis and Cancer -- Role of Autophagy in Immunity -- Autophagy and Senescence -- Role of Autophagy in Viral Defense and Replication -- Role of Autophagy in Intracellular Bacterial Infection -- Role of Autophagy in Heart Disease -- Role of Autophagy in Neurodegenerative Diseases -- Cross-Talk between Autophagy and Apoptosis -- Autophagy and Ubiquitination -- Aggresome: Ubiquitin Proteasome and Autophagy Systems -- Autophagy and Necroptosis -- Mitochondrial Fusion and Fission -- Selective Autophagies -- Allophagy -- Glycophagy -- Pexophagy -- References -- I: General Applications -- 2 Molecular Process and Physiological Significance of Mitophagy -- Introduction -- Selective Autophagy in Yeast -- Selective Autophagy in Higher Eukaryotes -- Mitochondrial Dysfunction in Age-Related Diseases -- Mitochondrial Quality Control Systems. , Mitophagy in Yeast -- Mitophagy in Mammalian Cells -- BNIP3L and BNIP3 -- FUNDC1 -- PARK2 and PINK1 -- Discussion and Perspectives -- References -- 3 Principles of Mitophagy and Beyond -- Introduction -- Yeast Mitophagy -- Principles and Mechanisms -- The Importance of Mitophagy in Yeast -- Mitophagy in Higher Eukaryotes -- Fundc1 -- NIX and BNIP3 -- Pink1 (and Parkin) -- General Conclusions -- Acknowledgments -- References -- 4 Quality Control in Mitochondria -- Mechanisms of Mitochondrial Quality Control -- Autophagy in S. cerevisiae -- An Overview of Mitophagy in S. cerevisiae -- Additional Mitochondrial Quality Control Mechanisms -- Causes of Mitophagy -- Yeast Proteins Involved in Mitophagy -- ATG Proteins -- MAP Kinases -- Phosphatases -- The RTG (Retrograde) Signaling Pathway and Mitophagy -- Uth1 -- Functional Homologues of Yeast Mitophagy Proteins in Mammals -- Mitochondrial Dynamics and Mitophagy -- Future Directions of Yeast Mitophagy Research -- References -- 5 Mitophagy: An Overview -- Snapshot: Mitophagy -- Molecular Mechanisms and Regulation -- Mitochondrial Dynamics and Mitophagy -- Monitoring Mitophagy -- Physiological and Pathological Roles of Mitophagy -- Development -- Aging -- Cancer -- Neurodegenerative Diseases -- Infection and Inflammation -- Preventive Measures for Mitophagy-Related Diseases -- Future Questions and Concluding Remarks -- Acknowledgments -- References -- II: Molecular Mechanisms -- 6 Mitophagy Induction and Curcumin-Mediated Sonodynamic Chemotherapy -- Introduction -- Alternative Therapeutic Strategies: Ultrasound Therapy and Sonodynamic Chemotherapy -- A Promising Sensitive Drug: Curcumin -- Discussion -- Acknowledgments -- References -- 7 Role of Nix in the Maturation of Erythroid Cells through Mitochondrial Autophagy -- Introduction -- Nix and Mitochondrial Autophagy in Erythroid Differentiation. , Expression of Nix during Terminal Erythroid Differentiation -- Nix Regulates Mitochondrial Autophagy in Reticulocytes -- Nix-Mediated Mitochondrial Clearance Involves Both Atg7-Dependent and Atg7-Independent Autophagy -- Mechanisms of Nix-Mediated Mitochondrial Autophagy -- Nix-Dependent Loss of Mitochondrial Membrane Potential in the Promotion of Mitochondrial Autophagy -- Nix as a Mitochondrial Receptor for Binding to Autophagosome -- Nix Domains Required for Mitochondrial Autophagy -- Conclusions -- Acknowledgments -- References -- 8 Role of the Antioxidant Melatonin in Regulating Autophagy and Mitophagy -- Introduction -- Aging -- Neurodegenerative Diseases -- Cancer -- Conclusions and Perspectives -- References -- 9 Ubiquitin Ligase-Assisted Selective Autophagy of Mitochondria: Determining Its Biological Significance Using Droso ... -- Introduction -- Drosophila Models for Parkinson's Disease -- Mitophagy and Mitochondrial Dynamics -- Muscle Degeneration Caused by Mitochondrial Defects -- Mitophagy and Protein Translation Signaling -- Crosstalk Between Mitophagy Signals and the Ubiquitin-Proteasome Pathway -- Possible Roles of Mitophagy in Neurons -- Regulators of Mitochondrial Maintenance Identified in Drosophila Studies -- Tools for the Detection of Mitophagy in Drosophila -- Concluding Remarks -- References -- 10 Atg32 Confers Selective Mitochondrial Sequestration as a Cargo for Autophagy -- Introduction -- Atg32, a Mitophagy-Specific Protein -- Genome-wide Screen for Mitophagy-Deficient Mutants in Yeast -- Localization and Topology of Atg32 -- Atg32 Interacts with Atg11 for Selective MitochondriaL Degradation -- Atg11, an Adaptor Protein for Selective Autophagy -- Atg32 is a Receptor Protein for Mitophagy that Interacts with Atg11 -- Phosphorylation of Atg32 Mediates Atg32-Atg11 Interactions and Mitophagy -- Atg32 Interacts with Atg8. , Induction and Regulation of Mitophagy -- Mitophagy Induction in Yeast -- Signaling Pathways that Regulate Mitophagy -- Other Factors Related to Mitophagy in Yeast -- Physiological Role of Mitophagy in Yeast -- Acknowledgments -- References -- 11 PARK2 Induces Autophagy Removal of Impaired Mitochondria via Ubiquitination -- Introduction -- Mitochondrial Dysfunction and Parkinson's Disease -- Park2/Parkin and Intracellular Quality Control -- Relevance of Parkin-Mediated Mitophagy to Parkinson's Disease Pathogenesis -- Concluding Remarks -- Acknowledgments -- References -- 12 Ubiquitination of Mitofusins in PINK1/Parkin-Mediated Mitophagy -- Introduction -- Mitochondrial Dynamics -- PINK1/Parkin-Mediated Mitophagy -- Ubiquitination of Mfn1 and Mfn2 by Parkin -- Consequences of Mfn Ubiquitination -- Conclusions and Perspectives -- Acknowledgments -- References -- 13 Mitochondrial Alterations and Mitophagy in Response to 6-Hydroxydopamine -- Introduction -- Mitochondrial Alterations -- Biochemical Mitochondrial Alterations -- Morphological Mitochondrial Alterations -- 6-OHDA and Mitochondrial Dynamics -- 6-OHDA and Autophagy -- Acknowledgments -- References -- III: Role in Disease -- 14 Role of Mitochondrial Fission and Mitophagy in Parkinson's Disease -- Introduction -- Mitochondrial Fission and PD -- Mitophagy -- Genetic Factors -- α-Synuclein -- Leucine-Rich Repeat Kinase 2 -- DJ-1 -- Parkin -- PTEN-Induced Kinase 1 -- Omi/HtrA2 -- Sporadic PD -- References -- 15 Mitophagy Controlled by the PINK1-Parkin Pathway Is Associated with Parkinson's Disease Pathogenesis -- Introduction -- Parkin has Ubiquitin Ligase Activity -- Genetic Association Between the PD Genes PARKIN and PINK1 -- Pink1 and Parkin are Involved in the Regulation of Mitochondrial Dynamics -- Parkin is Involved in the Elimination of Damaged Mitochondria Through the Mitophagy Pathway. , PINK1 Regulates the Mitochondrial Translocation of Parkin -- Molecular Regulation of PINK1 and Parkin -- PINK1 and Parkin Regulate Mitochondrial Motility -- Physiological and Pathological Roles of Mitophagy by the PINK1-Parkin Pathway -- Discussion -- Acknowledgments -- References -- 16 Loss of Mitochondria during Skeletal Muscle Atrophy -- Introduction -- Ubiquitin-Proteasome System Mediated Muscle Atrophy -- Autophagy-Lysosomal System Mediated Muscle Atrophy -- Mitophagy-Mediated Muscle Atrophy -- Mechanisms Underlying the Loss of Mitochondria During Muscle Atrophy -- Conclusion and Future Directions -- References -- 17 Role of Impaired Mitochondrial Autophagy in Cardiac Aging -- Introduction -- Mechanisms and Consequences of Mitochondrial Dysfunction in the Aging Heart -- Mitochondria as a Source of Oxidants -- Mechanisms of Mitochondrial Dysfunction in the Aging Heart -- Consequences of Mitochondrial Dysfunction on Heart Physiology -- Contribution of Impaired Mitochondrial Quality Control to Cardiac Aging -- Role of Altered Mitochondrial Dynamics in Cardiac Aging -- Contribution of Altered Mitochondrial Autophagy to Heart Senescence -- Mitochondrial Dysfunction and Quality Control: Novel Pharmacological Targets Against Cardiac Aging and Cardiovascular Disea ... -- Conclusion -- References -- Index. , English

Additional Edition: ISBN 0-12-405528-1

Additional Edition: ISBN 1-322-01798-0

Language: English