UID:
edoccha_9960074048302883
Format:
1 online resource (415 p.)
ISBN:
0-12-405167-7
Content:
Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate
Note:
Description based upon print version of record.
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Front Cover; Natural Hosts Of SIV: Implication In AIDS; Copyright; Contents; Epigraphy; Contributors; Introduction; Chapter 1 - Comparative Studies of Natural and Non-natural Hosts of SIV-An Overview; OVERVIEW; OUTLOOK; References; Chapter 2 - History of Simian Immunodeficiency Virus Discovery; SERENDIPITOUS PATHWAYS TO AN AIDS MODEL AND SIV'S AFRICAN ORIGIN; SIVMAC EMERGED FROM THE CALIFORNIA NATIONAL PRIMATE RESEARCH CENTER MACAQUE COLONY; SURVIVORS OF THE MACAQUE LYMPHOMA OUTBREAK SENT TO THE NEW ENGLAND AND WASHINGTON PRIMATE RESEARCH CENTERS
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WHAT'S IN A NAME? SIMIAN IMMUNODEFICIENCY VIRUS (AKA STLV-III, STLV-IIIAGM, AND HTLV-IV)ORIGINS OF SIVMAC FROM KURU EXPERIMENTS USING ASIAN RHESUS MONKEYS; BOB GORMUS AT THE TULANE NATIONAL PRIMATE RESEARCH CENTER UNCOVERS THE AFRICAN ORIGIN OF SIV; HIV-1 ANCESTRY DISCOVERED IN AN EX-PET CHIMPANZEE IN GABON; WAS SIVMAC THE IDEAL MODEL FOR AIDS?; ANCIENT ORIGINS OF THE SIV FAMILY IN AFRICA RAISE MORE QUESTIONS; References; Chapter 3 - Simian Immunodeficiency Virus Infections in the Wild; INTRODUCTION; HISTORY; SIV CLASSIFICATION; EVOLUTION OF SIVS
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HOW LONG WERE SIVS PRESENT IN NON-HUMAN PRIMATESCHALLENGES TO STUDY SIV INFECTION IN WILD NON-HUMAN PRIMATE POPULATIONS; SIV PREVALENCE AND MOLECULAR EPIDEMIOLOGY IN AFRICAN NON-HUMAN PRIMATES; TRANSMISSION OF SIMIAN RETROVIRUSES IN THEIR NATURAL HOSTS; HISTORY OF SIV IN THEIR NATURAL HOSTS; CONCLUSIONS; References; Chapter 4 - Properties of Human and Simian Immunodeficiency Viruses; INTRODUCTION; COMMON FEATURES OF PRIMATE LENTIVIRUSES; UNIQUE FEATURES OF HIV-1 AND HIV-2 RELATED PRIMATE LENTIVIRUSES; PRIMATE LENTIVIRAL CORECEPTOR TROPISM AND PATHOGENESIS; CONCLUSIONS AND PERSPECTIVES
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ReferencesChapter 5 - Simian Immunodeficiency Virus Infection of Chimpanzees (Pan troglodytes); INTRODUCTION; DISTRIBUTION OF SIVCPZ IN THE WILD; ORIGINS AND AGE OF SIVCPZ; OUTCOME OF SIVCPZ INFECTION: EARLY ASSUMPTIONS; AIDS IN WILD CHIMPANZEES?; COMPARISON OF SIVCPZ INFECTION WITH OTHER MODELS; INCREASED PATHOGENICITY OF THE SIVCPZ/HIV-1 LINEAGE?; FURTHER CONFLICTS IN THE HISTORY OF SIV INFECTION OF CHIMPANZEES; PERSPECTIVES FOR FUTURE WORK AND CONCLUSIONS; References; Chapter 6 - Pathology of Sooty Mangabeys (Cercocebus atys); INTRODUCTION; TAXONOMY; CLINICAL PATHOLOGY
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MUCOSAL B CELLS IN NATURAL HOSTS
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English
Additional Edition:
ISBN 0-12-404734-3
Language:
English
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