UID:
almahu_9948026792602882
Format:
1 online resource (377 p.)
ISBN:
1-281-04624-8
,
9786611046248
,
0-08-053999-8
Content:
Proteins: Analysis and Design focuses solely on individual experimental approaches, rather than on specific classes of proteins. The book provides insight into the important issues in protein science and how one can cope with them. These include all issues which explore the detailed relationship of protein structure to function. Key Features:* Provides problems and technical solutions* Includes posttranslational modifications* Uses synthetic peptides as biological models* Details mutagenesis and protein engineering* Covers design of protein structure and func
Note:
Description based upon print version of record.
,
Front Cover; Proteins Analysis and Design; Copyright Page; Contents; Dedication; Contributors; Preface; Introduction; Chapter 1. Current Problems and Technical Solutions in Protein Biochemistry; I. Introduction; II. Early Events in Signaling by Interferons: From Membrane Receptor to Induced Genes; III. Detection of Systems Components; IV. Identification of Components of Complex Systems; V. Analysis of Regulatory Modifications of Components of Complex Systems; VI. Analysis of Protein: Ligand Complexes; VII. Conclusion; References; Chapter 2. Posttranslational Modifications; I. Introduction
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II. Types of Posttranslational DerivativesIII. Types of Posttranslational Reactions: How Modifications Are Made; IV. Biological Functions of Posttranslational Modifications: Why Modifications Are Made; References; Chapter 3. Design and Use of Synthetic Peptides as Biological Models; I. Peptides as Structural Models of Proteins; II. Cell/Peptide Interactions; III. Protein/Peptide Interactions; IV. Peptides and Modulation of T-Cell Behavior; V. Enzyme/Peptide Interactions: Peptides as Enzyme Substrates; VI. Summary; References; Chapter 4. Site-Directed Mutagenesis and Protein Engineering
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I. IntroductionII. Why Alter Proteins?; III. Techniques for Oligonucleotide-Directed Mutagenesis; IV. Strategies for Engineering Proteins; V. Case Studies: Introduction of Function by Site-Directed Mutagenesis; VI. Conclusion; References; Chapter 5. De Novo Design of Protein Structure and Function; I. Introduction and Overview; II. De Novo Design of Structure; III. Characterizing the Design; IV. Selected Examples of Designed Proteins; V. De Novo Design of Function; VI. Design of Catalytic Proteins; VII. Summary and Future Directions; References; Index; Color Plate Section
,
English
Additional Edition:
ISBN 0-12-058785-8
Language:
English
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