UID:
almahu_9947367686202882
Format:
1 online resource (449 p.)
ISBN:
1-280-64158-4
,
9786610641581
,
0-08-045933-1
Series Statement:
Advances in phytomedicine, v. 2
Content:
Lead Molecules from Natural Products: Discovery and New Trends provides the reader with a thorough overview of current discoveries and trends in Natural Products research. This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design. Contributors describe their own laboratory experiences, revealing their findings, the legal issues encountered.The chapters, all of equally high quality, summarize years of
Note:
Description based upon print version of record.
,
Front cover; Title page; Copyright page; Table of contents; Preface to the Series; Preface; Reverse pharmacognosy: a new concept for accelerating natural drug discovery; Introduction; Pharmacognosy; Sample collection; Extraction; Activity-guided fractionation; Reverse pharmacognosy; Virtual chemical database; Target database; SelnergyTM; Ethnopharmacological database (ETPHDB); Applications of SelnergyTM; Building therapeutic focused libraries; Building family focused libraries; Estimating biological properties of a compound library; Protein flexibility; Lead leveraging
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Pharmacognosy and reverse pharmacognosy in natural drug discovery processFrom pharmacognosy to lead; From reverse pharmacognosy to lead; Repositioning of compounds; Conclusions and perspectives; References; Effects of plant extracts on gene expression profiling: from macroarrays to microarray technology; Introduction; Treatment of K562 cells with M. oleifera extracts leads to changes in gene expression profile; Modifications of the gene expression profile in human K562 cells treated with M. oleifera and E. officinalis plant extracts; Validation of the macroarray data by RT-PCR
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Conclusions and future perspectivesAcknowledgments; References; Effects of medicinal plant extracts on molecular interactions between DNA and transcription factors; Introduction; The electrophoretic mobility shift assay (EMSA) as a tool for identification of inhibitors of protein-DNA interactions; Filter-binding assay for the screening of inhibitors of TF/DNA interactions; Plant extracts and inhibition of protein-DNA interactions; Future perspectives; Acknowledgments; References; Plants with antitumor properties: from biologically active molecules to drugs; Introduction
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High-performance liquid chromatography (HPLC)Recently developed HPLC-based methods; The SEPBOX for isolation of high amounts of pure compounds from plant extracts; Gas chromatography/mass spectrometry (GC/MS); Plant extracts and plant-derived compounds in clinical trials; Future perspectives: biospecific interaction analysis (BIA) using surface plasmon resonance (SPR) and biosensor technologies for identification, isolation and characterization of bioactive compounds; Acknowledgements; References; Herbal extracts and compounds active against herpes simplex virus; Introduction
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Epidemiology of herpes simplex virusHSV structure and entry; Current anti-HSV therapy; Herpes simplex virus vaccine; Screening plants for antiviral activity; Plant extracts with activity against HSV; Plant compounds with anti-HSV activities; Modes of action of anti-HSV compounds; Topical microbicides; Discussion; References; Pharmacological modulation of cough reflex; Introduction; Definition of cough; Epidemiological data; Physiology of cough reflex; Larynx and pharynx - laryngopharyngeal cough; The tracheobronchial tree - tracheobronchial cough; Central nervous mechanisms in cough
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Pathophysiology of cough
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English
Additional Edition:
ISBN 0-444-51619-0
Language:
English
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