Kooperativer Bibliotheksverbund

UID:

Format: IX, 358 S. : graph. Darst.

ISBN: 0-387-96243-3 , 3-540-96243-3

Language: English

Subjects: Chemistry/Pharmacy

Keywords: NMR-Spektroskopie

Author information: Atta-ur-Rahman 1942-

UID:

Format: 1 Online-Ressource (781 S.).

ISBN: 978-0-444-50588-0

Series Statement: Studies in natural products chemistry 22

Language: English

Subjects: Chemistry/Pharmacy

URL: Volltext  (URL des Erstveröffentlichers)

URL: Volltext  (URL des Erstveröffentlichers)

Author information: Atta-ur-Rahman 1942-

UID:

Format: Online Ressource (XIII, 812 S.) : , Ill.

ISBN: 978-0-444-50469-2 , 0-444-50469-9

Series Statement: Studies in natural products chemistry 21

Note: Includes bibliographical references and index.

Language: English

Subjects: Chemistry/Pharmacy

URL: Volltext  (URL des Erstveröffentlichers)

URL: Volltext  (URL des Erstveröffentlichers)

Author information: Atta-ur-Rahman 1942-

UID:

Format: 1 Online-Ressource (xiii, 812 S.).

ISBN: 978-044-450-643-6 , 0-444-50643-8

Series Statement: Studies in natural products chemistry 24

Language: English

Subjects: Chemistry/Pharmacy

URL: Volltext  (URL des Erstveröffentlichers)

URL: Volltext  (URL des Erstveröffentlichers)

Author information: Atta-ur-Rahman 1942-

UID:

Format: Online Ressource (XIII, 850 S.) : , Ill.

ISBN: 978-0-444-82815-6 , 0-444-82815-X

Series Statement: Studies in natural product chemistry 19

Language: English

Subjects: Chemistry/Pharmacy

URL: Volltext  (URL des Erstveröffentlichers)

URL: Volltext  (URL des Erstveröffentlichers)

Author information: Atta-ur-Rahman 1942-

UID:

Format: 1 Online-Ressource.

ISBN: 978-044-450-105-9 , 0-444-50105-3

Series Statement: Studies in natural products chemistry 20

Note: Includes cumulative index volume 1-20. - Includes bibliographical references

Language: English

Subjects: Chemistry/Pharmacy

URL: Volltext  (URL des Erstveröffentlichers)

URL: Volltext  (URL des Erstveröffentlichers)

Author information: Atta-ur-Rahman 1942-

UID:

Format: 1 Online-Ressource (xiv, 757 S.).

ISBN: 978-0-444-82264-2 , 0-444-82264-X

Series Statement: Studies in natural products chemistry 16

Language: English

URL: Volltext  (URL des Erstveröffentlichers)

URL: Volltext  (URL des Erstveröffentlichers)

Author information: Atta-ur-Rahman 1942-

UID:

Format: 1 online resource (327 p.)

ISBN: 0-12-803964-7

Content: The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pro-angiogenesis is highly desirable for the treatment of cardiovascular diseases, wound healing disorders, and more. Efforts to understand the molecular basis, both for inhibition and induction, have yielded fascinating results. Originally published by Bentham and now distributed by Elsevier, Anti-Angiogenesis Drug Discovery and Development, Volume 2 is an compilation of well-written reviews on various aspects of the anti-angiogenesis process. These reviews ha

Note: Description based upon print version of record. , Front Cover; Anti-Angiogenesis Drug Discovery and Development Volume 2 ; Copyright ; Contents ; Preface ; List of Contributors ; Chapter 1: Mechanism of Controlling Blood Vessel Growth and Development and Identification of Therapeutics Against Pathological Angiogenesis ; Abstract ; Introduction ; An Historical Overview of Angiogenesis ; Types of Angiogenesis ; The Mechanism of Normal Angiogenesis ; Tumor Indduced Anngiogeneesis ; Assays for Angiogenesis ; Mechanism of Angiogenesis Inhibition ; Inhibitors of Growth Factors and Receptors ; An Overview of Anti-Angiogenic Therapy ; Conclusion , Acknowledgements Conflict of Interest ; References ; Chapter 2: Development of in vitro Method for Assaying Anti-Angiogenic Effect of Drugs ; Abstract ; Introduction ; Collagenn Gel Cullture of Aortic Eexplant ; Capillary Tube Formation ; Immunohistochemistry of Angiogenic Factors ; Adhesive Molecules (integrins) ; CD133 (Hematopoietic Stem/Progenitor Cell Marker ; Gene Array Analysis ; Anti-Angiogenic Drugs ; Collagen Gel Culture as an in vitro Model for Studyingvascular Injury ; Collagen Gel Culture of Various Organs ; Conclusion ; Acknowledgements ; Conflict of Interest ; Disclosures , References Chapter 3: Clear Cell Renal Cell Carcinoma as a Model of Pathological Angiogenesis: Which Actors to Target for Treatment? ; Abstract ; Introduction ; Targeted Therapies in Use ; Emergent Molecules in Phase III Clinical Trials ; Emergent Molecules in Phase II Clinical Trials ; Identification of Predictive Biomarkers of the Efficiency of Anti-Angiogenesis Treatments ; Discussions ; Acknowledgements ; Conflict of Interest ; Disclosure ; References ; Chapter 4: Inhibition of Angiogenesis in Cancer Management by Antioxidants: Ascorbate and P. Leucotomos ; Abstract ; Introduction , Cconclusion Acknowledgements ; Conflict of Interest ; Disclosure ; References ; Chapter 5: Development of Novel Anti-Cancer Strategies Based Onangiogenesis Inhibition ; Abstract ; Introduction ; Physiological Angiogenesis ; Pathological Angiogenesis ; Factors Responsible for Angiogenesis ; Molecules Involved in Angiogenesis ; Signal Transduction Pathways Involved in Angiogenesis ; Strategies for Targeting Angiogenesis ; Naturally Occurring Inhibitors ; Mimics for Angiogenesis ; Synthetic Inhibitors ; Concluding Remarks ; Acknowledgements ; Conflict of Interest ; References , Chapter 6: Discovery and Development of Antiangiogenetic Drugs in Ovarian Cancer Abstract ; Introduction ; Mechanisms of Action ; Resistance ; General Toxicities ; Agents Bevacizumab ; Aflibercept (VEGF Trap) ; BIBF1120 ; Additional Antiangiogenics ; MEDI3617 ; Novel Delivery of Antiangiogenics ; Limitations and Future Clinical Use ; Registration Strategies ; Combination Antivascular Therapies ; Conclusion ; Acknowledgements ; Conflict of Interest ; Competing Interests ; References ; Chapter 7: STAT3 Signaling in Cancer: Small Molecule Intervention as Therapy? ; Abstract , Introduction: Angiogenesis, VEGF and STAT3

Additional Edition: ISBN 0-12-803963-9

Language: English

UID:

Format: 1 online resource (415 pages) : , illustrations, tables.

ISBN: 0-444-63935-7 , 0-444-63929-2

Series Statement: Studies in Natural Products Chemistry, Volume 54

Note: Front Cover -- Studies in Natural Products Chemistry -- Copyright -- Contents -- Contributors -- Preface -- Chapter 1: A Conserved Family of DNA-Binding Peptides as New Potential Natural Antitumor Agents -- Introduction -- From Chalones to Growth Inhibitory Peptides -- Chalone Theory -- Growth Inhibitory Peptides -- Regulatory DNA-Binding Peptides -- Effects on DNA Template Activity -- Isolation of DNA-Binding Peptide -- Structural Characterization -- Effects of DNA-Binding Peptides on Cancer Cell Cultures -- Growth Rate and Cell Cycle -- Activation of G2 Checkpoint Pathway -- Apoptosis Induction -- DNA Synthesis Inhibition -- Perspectives for Cancer Therapy -- Strategies for Cancer Treatment -- DNA-Binding Peptides and Cancer -- Concluding Remarks -- References -- Chapter 2: Advances in the Chemistry of Natural and Semisynthetic Topoisomerase I/II Inhibitors -- Introduction -- Topoisomerases -- Alkaloids -- CPT and Its Derivatives -- Multidrug Resistance -- Other Alkaloids -- Flavonoids -- Triterpenes -- Quinones and Naphthoquinones -- Daunorubicin and Its Derivatives -- Phenols and Polyphenols -- Epipodophyllotoxines -- Fatty Acids -- Conclusions -- Aknowledgments -- Abbreviations -- References -- Chapter 3: Hopanoids in Cyanobacteria Biomass and Related Samples -- Introduction -- Physicochemical Properties, Biological Actions, Environmental Occurrence, and Practical Applications of Hopanoids -- General Characteristics of Cyanobacteria and Their Bioactive Metabolites -- Main Research Targets and Recent Advances in Hopanoid Analysis of Cyanobacteria Biomass and Related Samples -- Quantification Problems Concerning Main Research Targets -- Recent Advances in Hopanoid Analysis of Selected Complex Biological and Environmental Samples -- Concluding Remarks -- References -- Chapter 4: Antibacterial Potential of Diterpenoids. , Definition and Biosynthetic Origin of Diterpenes -- Plant Sources and Biological Activities of Diterpenes -- Antibacterial Properties of Diterpenes: An Overview -- Anticariogenic Potential of Diterpenes -- Diterpenes Against Periodontitis and Endodontic Infections -- Mechanisms of Action of the Antibacterial Activity of Diterpenes -- Conclusions and Remarks -- Acknowledgments -- References -- Further Reading -- Chapter 5: Chemistry and Bioactivity of ent-Kaurene Diterpenoids -- Introduction -- Biogenesis of ent-Kaurene Diterpenoids -- Total Synthesis of the ent-Kaurene Diterpenoids -- (±)-Kaurene (Ireland Group) -- (±)-Steviol Methyl Ester (Ziegler and Kloek Group) -- (±)-Steviol (Baran Group) -- (±)-Isosteviol (Snider Group) -- Cafestol (Corey Group) -- Cafestol (Hong Group) -- (-)-Methyl Kaurenoate (Ihara Group) -- Neotripterifordin (Corey Group) -- Dimethylshikoccidin (Paquette Group) -- Sculponeatin N (Zhai Group) -- Trichorabdal A and Longikaurin E (Reisman Group) -- Platensimycin (Nicolaou Group) -- Biological Activities of ent-Kauranoids and Their Structural Modifications -- Biological Activities of Platensimycin -- Structural Modifications at the Tetracyclic Ketolide Core of Platensimycin -- Isoplatensimycin -- Carbaplatensimycin (120) -- Other Analogues of Platensimycin -- Oxazinidinyl Platensimycin (143) -- Other Derivatives With Simplified Tetracyclic Core -- Modification at the Aromatic Portion of Platensimycin -- Homoplatensimide A (158) -- Platensimide A (160) -- Biological Activities of Oridonin -- Medicinal Chemistry Advances Based on Oridonin -- Derivatization on C-1 and/or C-14 Hydroxyl -- Modifications on the A Ring -- Dimeric Oridonin Derivatives -- 6,7-Seco-Oridonin Derivatives -- Spirolactone-Type Derivatives -- Enmein-Type Derivatives -- Concluding Remarks -- Acknowledgments -- Abbreviations -- References. , Chapter 6: Bioactive Compounds From Microalgae: Current Development and Prospects -- Introduction -- Microalgae and Its Derived Natural Products -- Model and Key Algal Genera -- Bioprospecting for New Algae -- Medicinally Important Natural Products -- Primary Screening for Bioactive Compounds From Microalgae -- Extraction Methods -- Screening Assays -- Antioxidant Assays -- Antimicrobial Assays -- Antiviral Assay -- Anticancer Assay -- Immunomodulatory Assay -- Bioassay-Guided Isolation and Structure Elucidation Process -- Biosynthesis and Biological Activities -- Biosynthesis -- Biological Activities -- Perspectives -- Concluding Remarks -- Acknowledgments -- References -- Chapter 7: Tabernaemontana Species: Promising Sources of New Useful Drugs -- Introduction -- Antioxidant Activity -- Enzyme Inhibition -- Antitumor Properties and Cytotoxicity -- Antiinflammatory and Antinociceptive Activity -- Neuropharmacological Activity -- Cardiovascular-Related Activities -- Antiprotozoal Activity -- Antimicrobial Activity -- Antibacterial Activity -- Antifungal Activity -- Antiviral Activity -- Other Activities -- Uterine Effects -- Estrogenic and Antiestrogenic Effects -- Gastrointestinal Effects -- Hepatic Effects -- Renal Effects -- Antidiabetic Effects -- Ophthalmologic Effects -- Antivenom Effects -- Wound-Healing Effects -- Germination Effects -- Insecticidal and Larvicidal Activity -- Nematicide and Antihelmintic Activity -- Toxicity Evaluation -- Conclusion -- References -- Chapter 8: Plant-Derived Antidiabetic Compounds Obtained From African Medicinal Plants: A Short Review -- Introduction -- Flavonoids and Other Phenolic Compounds -- Terpenoids -- Alkaloids -- Coumarins -- Tannins -- Other Compounds -- Conclusion -- Acknowledgments -- List of Abbreviations -- References. , Chapter 9: Homoisoflavonoids: Occurrence, Biosynthesis, and Biological Activity -- Introduction -- Biosynthesis -- Occurrence in Nature -- (I) Sappanin-Type -- (II) Scillascillin-Type -- (III) Brazilin-Type -- (IV) Caesalpin-Type -- (V) Protosappanin-Type -- Miscellaneous -- Biological Activity -- Antimicrobial Homoisoflavonoids -- Antidiabetic Homoisoflavonoids -- Cytotoxic/Anticancer Homoisoflavonoids -- Antiinflammatory Homoisoflavonoids -- Antimutagenic Homoisoflavonoids -- Other Biological Activities -- Conclusion -- Acknowledgments -- References -- Chapter 10: Anticancer Curcumin: Natural Analogues and Structure-Activity Relationship -- Introduction -- Curcumin Structure -- Structurally Similar Compounds/Natural Analogues -- Relative Potency of Curcumin and its Natural Analogues -- Curcumin Metabolites -- Cytotoxic Properties Against Tumor Cells and Structure-Activity Relationship -- Structure-Activity Correlation of Curcuminoids -- Anticarcinogenic Activity -- Anticancer Properties -- Molecular Targets of Curcumin -- Clinical Studies -- Conclusion -- References -- Index -- Back Cover.

Language: English

UID:

Format: 1 online resource (487 p.)

ISBN: 0-12-803962-0

Content: Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer

Note: Description based upon print version of record. , Front Cover; Recent Advances in Medicinal Chemistry, Volume 1; Copyright; Contents ; Foreword ; Preface ; List of Contributors ; Chapter 1: New Functions of Old Drugs: Aureolic Acid Group of Anti-Cancer Antibiotics and Non-Steroidal Anti-Inflammatory Drugs ; Abstract ; 1. Introduction ; 2. Principal Functions of Nsaids and Aureolic Acid Anticancer Antibiotics and Their Mechanism of Action ; 3. Other Functions of These Drugs and Mechanism of Actions ; 4. Chemical Dissection of the Drugs to Understand Alternate Functions ; 5. Conclusion ; Acknowledgements ; Conflict of Interest ; Disclosure , References Chapter 2: Updated Report on a Novel Mercaptopyruvate Sulfurtransferase Thioredoxin-Dependent Redox-Sensing Molecular Switch: A Mechanism for the Maintenance of Cellular Redox Equilibrium ; Abstract ; Introduction ; A Redox-sensing Molecular Switch Formed Via an Intermolecular Disulfide Bond ; Low Redox Potential Sulfenate Formation at a Catalytic Site Cysteine: Another Mechanism by Which MST Serves as an Anti-oxidant Protein ; Conclusions ; Acknowledgements ; Conflict of Interest ; Disclosure ; References , Chapter 3: Characterization of Inorganic Nanomaterials as Therapeutic Vehicles Abstract ; Introduction ; Concluding Remarks ; Acknowledgements ; Conflict of Interest ; Disclosure ; References ; Chapter 4: Aromatase Inhibitors: A New Reality for the Adjuvant Endocrine Treatment of Early-Stage Breast Cancer in Postmenopausal Women ; Abstract ; Introduction ; Conclusions ; Acknowledgements ; Conflict of Interest ; Disclosure ; References ; Chapter 5: Bacterial FabH: Towards the Discovery of New Broad-Spectrum Antibiotics ; Abstract ; Introduction ; Bacterial Type II Fas the Biological Process , Three Dimensional Structure of FabH Substrate Binding and Specificity ; Catalytic Mechanism and Substrate Binding ; Molecular Modeling Studies of FabH ; Concluding Remarks ; Acknowledgements ; Conflict of Interest ; Disclosure ; References ; Chapter 6: Tannins and Their Influence on Health ; Abstract ; 1. Introduction ; 2. Classification of Tannins ; 3. Absorption and Metabolism of Tannins ; 4. Biological Activity ; 5. Human Intervention Studies ; 6. Adverse and Undesirable Effects ; 7. Conclusions ; Acknowledgements ; Conflict of Interest ; Disclosure ; Abbreviations ; References , Chapter 7: Rho-GTPases and Statins: A Potential Target and a Potential Therapeutic Tool Against Tumors? Abstract ; Introduction ; Role of RhoA in Normal and Tumor Cells ; Statins Inhibit RhoA Activity ; Statins and Tumor Growth/apoptosis ; Statins and Angiogenesis ; Statins and Metastasis ; Statins, Chemotherapy Efficacy and Multidrug Resistance ; Statins and Chemoprevention of Tumors ; Statins in Cancer Treatment ; Acknowledgements ; Conflict of Interest ; Disclosure ; References ; Chapter 8: Carotenoids that are Involved in Prostate Cancer Risk ; Abstract ; Introduction , Types of Carotenoids and Their Distribution in Diets

Additional Edition: ISBN 0-12-803961-2

Language: English