UID:
almafu_9961427407402883
Format:
1 videorecording (40 min., 49 sec.) :
,
sound, color.
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004049
Series Statement:
Henry Stewart talks
Content:
Audio-visual presentation : Filovirus history ; Filovirus genes, proteins and structure ; Filovirus replication cycle ; Evasion of interferon responses by filoviruses ; Filovirus vaccines.
Note:
Retrieved April 15, 2024, from https://hstalks.com/bs/357/.
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Printable Handouts -- Navigable Slide Index -- Introduction -- Marburg virus history -- Ebola virus history -- Known Ebola virus outbreaks -- Information to family members of Ebola patients -- Genes and gene products -- Filovirus structure -- Ebola virus entry -- Structure of GP -- Filovirus RNA synthesis -- Ebola minigenome with GFP-CAT fusion -- Ebola minigenome assay -- VP40 late domains mediate viral budding -- Ebola virus pathogenesis -- The interferon system (1) -- The interferon system (2) -- delNS1 virus complementation assay -- VP35 protein complements growth of delNS1 virus -- IFN beta-reporter assay of interferon function -- VP35 blocks SeV activation of ISRE-54 promoter -- VP35 inhibits virus-induced IFN-beta expression -- VP24 inhibits IFN alpha/beta-induced signaling? -- EBOV inhibits PY-STAT1 nuclear accumulation -- STAT1 nuclear import -- VP24 interacts with karyopherin alpha 1 -- VP24 inhibits interaction of STAT1 with K-alpha-1 -- Ebola viruses must be adapted to be lethal in mice -- Interferon-alpha/beta receptor knockout mice -- Genetic changes during mouse adaptation -- Growth in the presence of IFN alpha/beta -- Vaccines -- Vesicular stomatitis virus-based vaccine -- Future directions.
Language:
English
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