Format:
1 Online-Ressource (IV, 98 Seiten, 4141 KB)
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Illustrationen, Diagramme
Content:
Frailty and sarcopenia share some underlying characteristics like loss of muscle mass, low muscle strength, and low physical performance. Imaging parameters and functional examinations mainly assess frailty and sarcopenia criteria; however, these measures can have limitations in clinical settings. Therefore, finding suitable biomarkers that reflect a catabolic muscle state e.g. an elevated muscle protein turnover as suggested in frailty, are becoming more relevant concerning frailty diagnosis and risk assessment. 3-Methylhistidine (3-MH) and its ratios 3-MH-to-creatinine (3-MH/Crea) and 3 MH-to-estimated glomerular filtration rate (3-MH/eGFR) are under discussion as possible biomarkers for muscle protein turnover and might support the diagnosis of frailty. However, there is some skepticism about the reliability of 3-MH measures since confounders such as meat and fish intake might influence 3-MH plasma concentrations. Therefore, the influence of dietary habits and an intervention with white meat on plasma 3-MH was determined in young ...
Note:
kumulative Dissertation
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Dissertation Universität Potsdam 2019
Additional Edition:
Erscheint auch als Druck-Ausgabe Kochlik, Bastian Max Relevance of biomarkers for the diagnosis of the frailty syndrome Potsdam, 2019
Language:
English
Keywords:
Hochschulschrift
DOI:
10.25932/publishup-44118
URN:
urn:nbn:de:kobv:517-opus4-441186
URL:
https://nbn-resolving.org/urn:nbn:de:kobv:517-opus4-441186
URL:
https://d-nb.info/1218405457/34
Author information:
Schwerdtle, Tanja 1975-
Author information:
Müller-Werdan, Ursula 1961-
Author information:
Grune, Tilman 1962-
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