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  • 1
    UID:
    almahu_9949251270502882
    Format: 1 online resource (XIII, 363 p. 79 illus., 56 illus. in color.)
    Edition: 1st ed. 2018.
    ISBN: 1-4939-8559-0
    Series Statement: Methods in Molecular Biology, 1806
    Content: This volume explores experimental strategies to study progranulin as a regulatory protein in biological and disease processes. The chapters in this book are divided into four parts: Part One is an introduction to the topic; Part Two looks at analytical and in vitro methods to study progranulin biology; Part Three discusses the role of progranulin in cancer; and Part Four describes the process of using animal models to study progranulin in health and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Progranulin: Methods and Protocols is a valuable resource for experienced researchers who want to expand their studies of this field, and newcomers who want to begin including progranulin into their work.”.
    Note: A Brief Overview of Progranulin in Health and Disease -- Chromatographic Methods for the Purification of Granulin Peptides -- Methods for Expression and Purification of Biologically Active Recombinant Progranulin -- Large-Scale Generation of Recombinant Granulin Peptides in E. coli -- Nuclear Magnetic Resonance Spectroscopy in Analysis of Granulin Three-Dimensional Structure and Cysteine Bridging -- Data Mining: Applying the AD&FTD Mutation Database to Progranulin -- Measurement of Circulating Progranulin (PGRN/GP88/GEP) by Enzyme-Linked Immunosorbent Assay and Application in Human Diseases -- Immunohistochemical Detection of Progranulin (PGRN/GP88/GEP) in Tumor Tissues as a Cancer Prognostic Biomarker -- Analysis of Progranulin-Mediated Akt and MAPK Activation -- Mouse Monoclonal Antibodies Against Progranulin (PGRN/GEP) as Therapeutics in Preclinical Cancer Models -- Methods to Analyze the Role of Progranulin (PGRN/GEP) on Cancer Stem Cell Features -- Methods to Study the Role of Progranulin in the Tumor Microenvironment -- Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo using Caenorhabditis elegans -- The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response -- Application of Zebrafish and Knockdown Technology to Define Progranulin Neuronal Function -- Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout Mice -- Methods to Investigate the Protection Againts Neurodegenerative Disorders Provided by Progranulin Gene Transfer in the Brain -- The Interaction between Progranulin with Sortilin and the Lysosome -- Methods to Study the Role of Progranulin in Preimplanatation Mouse Embryo Development -- Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-Inflammatory Activity of Progranulin in Inflammatory Arthritis -- Methods for Studying the Function of Progranulin in Atherosclerosis using Both Knockout Mice Models and In Vitro Studies -- Methods to Investigate the Roles of Prgranulin in Angiogenesis Using In Vitro Strategies and Transgenic Mouse Models.
    Additional Edition: ISBN 1-4939-8557-4
    Language: English
    Keywords: Llibres electrònics ; Llibres electrònics ; Llibres electrònics ; Llibres electrònics
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  • 2
    Book
    Book
    Harlow, England [u.a.] : Addison-Wesley
    UID:
    b3kat_BV012712925
    Format: XXV, 221 S. , Ill., graph. Darst. , 1 CD-ROM (12 cm)
    ISBN: 0201343010
    Note: Systemvoraussetzungen: Suitable for Mac and Windows (3.1) and above systems
    Language: English
    Subjects: Engineering
    RVK:
    Keywords: Digitale Nachrichtentechnik
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  • 3
    UID:
    almafu_BV046922369
    Format: 252 Seiten : , Illustrationen , 1 CD-ROM (12 cm)
    Edition: 1. Auflage
    ISBN: 978-3-8017-2985-1
    Series Statement: Therapeutische Praxis
    Uniform Title: The brain injury rehabilitation workbook
    Additional Edition: Erscheint auch als Online-Ausgabe, PDF ISBN 978-3-8409-2985-4
    Additional Edition: Erscheint auch als Online-Ausgabe, EPUB ISBN 978-3-8444-2985-5
    Language: German
    Subjects: Psychology , Medicine
    RVK:
    RVK:
    RVK:
    Keywords: Schädel-Hirn-Trauma ; Rehabilitation ; Psychotherapie ; Hirnschädigung ; Verletzung ; Rehabilitation ; Exekutive Funktionen ; Kommunikation ; Stimmung ; Selbstbild
    Author information: Wilson, Barbara A. 1941-
    Author information: Thoma, Patrizia 1979-
    Author information: Winson, Rachel
    Author information: Suchan, Boris 1966-
    Author information: Bateman, Andrew
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  • 4
    Book
    Book
    London : Pitman
    UID:
    b3kat_BV002211451
    Format: 385 Seiten , Diagramme
    Edition: first published
    ISBN: 0273027875
    Series Statement: Pitman computer systems series.
    Language: English
    Keywords: Digitale Signalverarbeitung
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  • 5
    UID:
    gbv_1029396639
    ISSN: 0144-686X
    In: Ageing & society, Cambridge [u.a.] : Cambridge Univ. Press, 1981, 38(2018), 9, Seite 1912-1932, 0144-686X
    In: volume:38
    In: year:2018
    In: number:9
    In: pages:1912-1932
    Language: English
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  • 6
    UID:
    almahu_BV013898733
    Format: XIII, 664 S. : , Ill., graph. Darst. , 1 CD-ROM (12 cm)
    Edition: 1. publ.
    ISBN: 0-201-39851-6
    Language: English
    Subjects: Engineering , Computer Science
    RVK:
    RVK:
    Keywords: Digitale Signalverarbeitung
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  • 7
    UID:
    kobvindex_ZLB34408177
    Format: 250 Seiten , CD-ROM , 29,7 cm
    Edition: 1. Auflage
    ISBN: 9783801729851
    Content: Das praxisorientierte Therapiemanual ermöglicht einen ganzheitlichen Behandlungsansatz und unterstützt Behandelnde aus verschiedenen Berufsfeldern bei der Arbeit mit Patientinnen und Patienten mit erworbenen Hirnschädigungen. Es enthält zahlreiche Beispiele und praktische Handlungsempfehlungen und hilft so, im ersten Schritt ein Modell der Stärken und Schwächen der betroffenen Personen und ihrer Familien zu entwickeln. Anschließend werden wirksame Therapieansätze zum Erlernen von Fertigkeiten und Entwickeln kompensatorischer Strategien in zentralen Bereichen wie Aufmerksamkeit, Gedächtnis, exekutive Funktionen, Stimmung und Kommunikation vorgestellt. Ein eigenes Kapitel widmet sich den erlebten Veränderungen der eigenen Identität, die zu den typischen Folgen einer Hirnschädigung zählen. Die beiliegende CD-ROM enthält zahlreiche Arbeitsblätter, die mit Patientinnen und Patienten im Rahmen der Psychoedukation bearbeitet werden können oder als praktisches Übungsmaterial dienen.
    Note: Deutsch
    Language: German
    Keywords: Hirnschädigung ; Verletzung ; Rehabilitation ; Exekutive Funktionen ; Kommunikation ; Stimmung ; Selbstbild
    Author information: Wilson, Barbara A.
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  • 8
    UID:
    gbv_883415674
    Format: Online-Ressource (1 online resource (377 p.)) , digital, PDF file(s).
    Edition: Online-Ausg.
    ISBN: 9780511581083
    Content: The aim of neuropsychological rehabilitation is to enable people with cognitive, emotional, or behavioural deficits to achieve their maximum potential in the domains of psychological, social, leisure, vocational or everyday functioning. Describing the holistic programme devised and adopted at the world famous Oliver Zangwill Centre and embracing a broad theoretical base, incorporating a variety of frameworks, theories and models, this book proposes an integrated approach to brain injury rehabilitation by an interdisciplinary team. The coverage explains the underlying principles involved, describes the group therapies employed, highlights a selection of real case examples and reviews the outcomes measured and achieved. This book is essential reading for clinical neuropsychologists, clinical psychologists, speech and language therapists, occupational therapists, psychiatrists, neurologists, physiotherapists, social workers and nurses
    Content: Caroline : treating post-traumatic stress disorder after traumatic brain injury / Jonathan J. Evans and W. Huw Williams -- Interdisciplinary vocational rehabilitation addressing pain, fatigue, anxiety, and impulsivity : Yusuf and his 'new rules for business and life' / Fergus Gracey, Donna Malley, and Jonathan J. Evans -- Judith : learning to do things 'at the drop of a hat' : behavioural experiments to explore and change the 'meaning' in meaningful functional activity / Fergus Gracey, Susan Brentnall, and Rachel Megoran -- Simon : brain injury and the family : the inclusion of children, family members, and wider systems in the rehabilitation process / Siobhan Palmer, Kate Psaila, and Giles Yeates -- Adam : extending the therapeutic milieu into the community in the rehabilitation of a client with severe aphasia and apraxia / Jacqui Cooper and Andrew Bateman -- Malcolm : coping with the effects of Balint's syndrome and topographical disorientation / Barbara A. Wilson -- Kate : cognitive recovery and emotional adjustment in a young woman who was unresponsive for several months / Barbara A. Wilson -- Is this approach effective? : outcome measurement at the Oliver Zangwill Centre / Andrew Bateman
    Content: Towards a comprehensive model of neuropsychological rehabilitation / Barbara A. Wilson and Fergus Gracey -- Evidence for the effectiveness of neuropsychological rehabilitation / Barbara A. Wilson -- Goal setting as a way of planning and evaluating neuropsychological rehabilitation / Barbara A. Wilson, Jonathan J. Evans, and Fergus Gracey -- The Oliver Zangwill Centre approach to neuropsychological rehabilitation / Barbara A. Wilson ... [et al.] -- The understanding brain injury (UBI) group / Barbara A. Wilson, Andrew Bateman, and Jonathan J. Evans -- The cognitive group, part 1 : attention and goal management / Jonathan J. Evans -- The cognitive group, part 2 : memory / Jonathan J. Evans -- The mood management group / Kate Psaila and Fergus Gracey -- The psychological support group / Fergus Gracey ... [et al.] -- Working with families in neuropsychological rehabilitation / Giles Yeates -- Communication group / Clare Keohane -- Practically based project groups / Donna Malley, Andrew Bateman, and Fergus Gracey -- Peter : successful rehabilitation following a severe head injury with cerebro vascular complications / Barbara A. Wilson and Jonathan J. Evans -- Lorna : applying models of language, calculation, and learning within holistic rehabilitation : from dysphasia and dyscalculia to independent cooking and travel / Leyla Prince ... [et al.] --
    Note: Title from publisher's bibliographic system (viewed on 05 Oct 2015)
    Additional Edition: ISBN 9780521841498
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-052-184-149-8
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 9780521841498
    Language: English
    Author information: Wilson, Barbara A. 1941-
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