UID:
almafu_9959076721002883
Format:
1 online resource (181 p.)
ISBN:
3-8055-9909-9
Series Statement:
Endocrine development, volume 25
Content:
The ghrelin story started more than 30 years ago with the discovery of synthetic GH secretagogues. Only in 1999 was ghrelin‚ a natural GH-releasing peptide, discovered. Ghrelin, however, is much more than simply a natural GH secretagogue. In fact, this hormone is one of the most important factors known for regulating appetite and energy expenditure. Furthermore, ghrelin is the trigger for other neuroendocrine, metabolic and nonendocrine actions. This book, written by researchers who provided the major contributions to our current knowledge of this complex system, gives a comprehensive overview of the recent advances in ghrelin research. The hormone's influence on the cardiovascular, metabolic and gastroenteropancreatic system, hypothalamus-pituitary-adrenal axis, prolactin secretion, thyroid axis, gonadal axis as well as on behavior is discussed in detail. Furthermore, the clinical perspectives for ghrelin-derived therapeutic products are presented. Illustrating the tight inter-relationship between endocrinology, metabolism, cardiovascular disease and internal medicine, this book is essential reading for all scientists interested in appetite control, body weight and energy expenditure, as well as diabetes mellitus and neuroendocrinology.
Note:
Description based upon print version of record.
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""Cover""; ""Front Matter""; ""Contents""; ""Preface""; ""Ghrelin Discovery: A Decade After""; ""Abstract""; ""Beginning""; ""Stomach""; ""A Novel Peptide""; ""After the Discovery of Ghrelin""; ""Epilogue""; ""References""; ""The Ghrelin Receptors (GHS-R1a and GHS-R1b)""; ""Abstract""; ""History""; ""GHS-R1a, Glucose Homeostasis and Obesity""; ""GHS-R1a in the Brain""; ""GHS-R1a Heterodimerization with Dopamine Receptors in the Brain""; ""GHS-R1a and Neuroprotection""; ""Impact of GHS-R1a Activation in the Cardiovascular System""
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""Potential Benefits of GHS-R1a Activation during Malnutrition and Cachexia""""GHS-R1a in Other Aging-Related Conditions""; ""Other Ghrelin Receptors""; ""Conclusion""; ""References""; ""Discovery of Ghrelin O -Acyltransferase""; ""Abstract""; ""From the U-Factor to GOAT""; ""Discovery of GOAT""; ""Pattern of GOAT mRNA and Protein Expression in Tissues""; ""Implications of GOAT in Metabolism and Metabolic Disorders""; ""Conclusions""; ""Acknowledgments""; ""References""; ""Genetics of the Ghrelin System""; ""Abstract""; ""Genetic Studies in Humans""; ""Eating Behaviour""; ""Metabolism""
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""Conclusions""""References""; ""Ghrelin and the Gut""; ""Abstract""; ""Relationship of Ghrelin with Motilin""; ""Distribution of Ghrelin Along the Gastrointestinal Tract""; ""Receptor Distribution and Cross-Reactivity with Motilin""; ""Effects of Ghrelin on Gut Function""; ""Gastroprotection""; ""Intestinal Inflammation""; ""Gastrointestinal Motility""; ""Pathophysiology""; ""Ghrelin Agonists for Motility Disorders""; ""References""; ""Ghrelin as a GH-Releasing Factor""; ""Abstract""; ""GH Secretion and Role of Ghrelin""; ""Does Circulating Ghrelin Act on GH Secretion Control?""
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""Interactions between Ghrelin and Obestatin to Regulate GH Secretion""""Ghrelin and GH in Elderly""; ""Pharmacology of the Ghrelin/GHS-R1a System""; ""Concluding Remarks""; ""References""; ""Other than Growth HormoneNeuroendocrine Actions of Ghrelin""; ""Abstract""; ""Hypothalamo-Pituitary-Adrenal Axis""; ""Lactotroph Function""; ""Hypothalamo-Pituitary-Thyroid Axis""; ""Hypothalamo-Pituitary-Gonadal Axis""; ""Neuroendocrine Actions of the Alternative Ghrelin Gene Products: Unacylated Ghrelin and Obestatin ""; ""Conclusions""; ""References""
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""Ghrelin, the Gonadal Axis and the Onset of Puberty""""Abstract""; ""Metabolic Control of the Reproductive Axis along the Lifespan""; ""Ghrelin and the Metabolic Control of Reproduction: General Considerations""; ""Ghrelin and the Control of Puberty: Experimental Evidence""; ""Ghrelin and the Control of the Gonadotropic Axis in Adulthood""; ""Modes and Sites of Action of Ghrelin for the Central Control of Puberty andGonadotropic Axis""; ""Ghrelin and Direct Control of the Gonads: Evidence from Expression Studies""
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""Ghrelin and Direct Control of the Gonads: Evidence from Functional Studies""
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English
Additional Edition:
ISBN 3-8055-9908-0
Language:
English
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