UID:
almahu_9947391666802882
Format:
1 online resource (various pagings) :
,
illustrations (some color).
ISBN:
9780750310949
,
9780750311250
Series Statement:
IOP expanding physics,
Content:
Written for researchers and postgraduate students with a background in physics or applied mathematics and a desire to apply their skills to problems in the life sciences, this beautifully illustrated and stimulating book develops an understanding of the gene-to-trait problem in the context of evolutionary dynamics, from the modern perspective of integrative biology. The gene-to-trait problem resides at the heart of a great many questions in biology. The author presents both elementary and advanced material in a way that brings out how this gene-to-trait problem is treated in the contexts of bioinformatics and evolutionary dynamics. Key ideas and techniques that underlie some of the most-used bioinformatics methods are discussed in an integrative context and a wide range of examples of mathematical models of living things is developed in an evolutionary framework.
Note:
"Version: 20150701"--Title page verso.
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Preface -- Acknowledgements -- 1. Introduction -- 1.1. Of snails and snakes -- 1.2. The three key elements -- 1.3. Stochasticity -- 1.4. Towards a mathematics of evolution -- 1.5. Organization of this book
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2. Cell biology and molecular genetics -- 2.1. Cellular architecture and proliferation -- 2.2. DNA, RNA and proteins -- 2.3. Metabolism
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3. Phylogeny and development -- 3.1. Phylogenic trees -- 3.2. Development
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4. Elementary evolutionary dynamics -- 4.1. Conceptual challenges and the standard assumption -- 4.2. Haploids -- 4.3. Diploids -- 4.4. Projection onto tightly linked clusters of loci -- 4.5. Drift and fixation
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5. Probability and measurement -- 5.1. Fundamental laws of probability -- 5.2. Random variables and their distributions -- 5.3. Expectation and variance -- 5.4. Common distributions and their properties -- 5.5. Measurement scales
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6. Statistical inference and estimation -- 6.1. The essential ideas -- 6.2. Justifying the likelihood ratio principle -- 6.3. Linking alleles to traits -- 6.4. Microarrays: the stepping down procedure -- 6.5. Analysis of bivariate data
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7. Sequence, structure and function -- 7.1. Principles of dynamic programming -- 7.2. Sequence phylogenies -- 7.3. Sequence alignment -- 7.4. Deep structure -- 7.5. From sequence to function
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8. Analysis of quantitative trait loci -- 8.1. Recombinant distributions -- 8.2. Genetic markers and mapping -- 8.3. The number of quantitative trait loci
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9. Evolutionary dynamics of QTL -- 9.1. Heritability -- 9.2. Dynamics of the additive genetic component -- 9.3. The persistence of sex
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10. Adaptive dynamics and speciation -- 10.1. Adaptive dynamics -- 10.2. Fisher's law for adaptive dynamics -- 10.3. Adaptive radiations and mass extinctions
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11. Traits as objects of selection -- 11.1. Regimenting traits -- 11.2. Scope and limitations of the additive genetic model
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12. Fitness and optimality -- 12.1. Evolution of protandry in butterflies -- 12.2. Evolution of juvenility -- 12.3. Evolution of homeostasis -- 12.4. Fitness probes
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Appendices. -- A. Species, speciation and systematics -- B. Dangerous ideas -- C. Dynamics -- D. Constrained optimization -- E. Thermal physics.
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Also available in print.
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Mode of access: World Wide Web.
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System requirements: Adobe Acrobat Reader.
Additional Edition:
Print version: ISBN 9780750310956
Language:
English
DOI:
10.1088/978-0-7503-1094-9
URL:
http://iopscience.iop.org/book/978-0-7503-1094-9
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