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  • 1
    Online Resource
    Online Resource
    Marrow protection : transduction of hematopoietic cells with drug resistance genes (1999)
    Basel :Karger,
    Details
    UID:
    edoccha_BV036069230
    Format: 1 Online-Ressource (VII, 184 Seiten) : , Illustrationen.
    ISBN: 978-3-318-00397-0
    Series Statement: Progress in experimental tumor research Vol. 36
    Content: Authored by experts in the field, this volume provides a comprehensive review of the problems and opportunities in gene therapy focusing on the use of various drug resistance genes to provide protection of hematopoietic cells against drug toxicity.General topics include basic principles of gene transfer, optimizing conditions for gene transfer in hematopoietic cells, and gene transfer in the nonmyeloablated host. Specific chapters describe constructions and preclinical studies of specific genes that impart resistance to anticancer drugs when expressed in hematopoietic cells including MDR-1, mutated forms of human methylguanine-DNA-methyltranferase, mutant forms of dihydrofolate reductase and thymidylate synthase, dihydropyrimidine dehydrogenase and cytidine deaminase. For successful transfer of drug resistance genes, the possibility that they may be used as selectable markers and that marrow ablation may not be required are important considerations.This book is especially timely, as clinical trials with these drug resistance genes are expected to increase markedly in the next few years. It should appeal to all interested in stem cell biology and gene therapy, as well as clinicians who look forward to using this technology in their practice
    Note: important reading for anyone interested in gene therapy
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-6828-9
    Language: English
    Subjects: Medicine
    RVK:
    XH 3239
    Keywords: Blutstammzelle ; Transduktion ; Arzneimittelresistenz ; Resistenzgen ; Cytostatikum ; Immunsuppression ; Granulozytopenie ; Blutstammzelle ; Gentransfer ; Arzneimittelresistenz ; Aufsatzsammlung
    DOI: 10.1159/isbn.978-3-318-00397-0
    URL: Volltext
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Online Access
    Open Access Request
    HU Berlin
    EUV Frankfurt
    TH Brandenburg
    TH Wildau
    Charité
    TU Berlin
  • 2
    Online Resource
    Online Resource
    Marrow protection : transduction of hematopoietic cells with drug resistance genes (1999)
    Basel :Karger,
    Details
    UID:
    almahu_BV036069230
    Format: 1 Online-Ressource (VII, 184 Seiten) : , Illustrationen.
    ISBN: 978-3-318-00397-0
    Series Statement: Progress in experimental tumor research Vol. 36
    Content: Authored by experts in the field, this volume provides a comprehensive review of the problems and opportunities in gene therapy focusing on the use of various drug resistance genes to provide protection of hematopoietic cells against drug toxicity.General topics include basic principles of gene transfer, optimizing conditions for gene transfer in hematopoietic cells, and gene transfer in the nonmyeloablated host. Specific chapters describe constructions and preclinical studies of specific genes that impart resistance to anticancer drugs when expressed in hematopoietic cells including MDR-1, mutated forms of human methylguanine-DNA-methyltranferase, mutant forms of dihydrofolate reductase and thymidylate synthase, dihydropyrimidine dehydrogenase and cytidine deaminase. For successful transfer of drug resistance genes, the possibility that they may be used as selectable markers and that marrow ablation may not be required are important considerations.This book is especially timely, as clinical trials with these drug resistance genes are expected to increase markedly in the next few years. It should appeal to all interested in stem cell biology and gene therapy, as well as clinicians who look forward to using this technology in their practice
    Note: important reading for anyone interested in gene therapy
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-6828-9
    Language: English
    Subjects: Medicine
    RVK:
    XH 3239
    Keywords: Blutstammzelle ; Transduktion ; Arzneimittelresistenz ; Resistenzgen ; Cytostatikum ; Immunsuppression ; Granulozytopenie ; Blutstammzelle ; Gentransfer ; Arzneimittelresistenz ; Aufsatzsammlung
    DOI: 10.1159/isbn.978-3-318-00397-0
    URL: Volltext
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Online Access
    Open Access Request
    HU Berlin
    EUV Frankfurt
    TH Brandenburg
    TH Wildau
    Charité
    TU Berlin
  • 3
    Online Resource
    Online Resource
    Marrow protection : transduction of hematopoietic cells with drug resistance genes (1999)
    Basel : Karger
    Details
    UID:
    b3kat_BV036069230
    Format: 1 Online-Ressource (VII, 184 Seiten) , Illustrationen
    ISBN: 9783318003970
    Series Statement: Progress in experimental tumor research Vol. 36
    Content: Authored by experts in the field, this volume provides a comprehensive review of the problems and opportunities in gene therapy focusing on the use of various drug resistance genes to provide protection of hematopoietic cells against drug toxicity.General topics include basic principles of gene transfer, optimizing conditions for gene transfer in hematopoietic cells, and gene transfer in the nonmyeloablated host. Specific chapters describe constructions and preclinical studies of specific genes that impart resistance to anticancer drugs when expressed in hematopoietic cells including MDR-1, mutated forms of human methylguanine-DNA-methyltranferase, mutant forms of dihydrofolate reductase and thymidylate synthase, dihydropyrimidine dehydrogenase and cytidine deaminase. For successful transfer of drug resistance genes, the possibility that they may be used as selectable markers and that marrow ablation may not be required are important considerations.This book is especially timely, as clinical trials with these drug resistance genes are expected to increase markedly in the next few years. It should appeal to all interested in stem cell biology and gene therapy, as well as clinicians who look forward to using this technology in their practice
    Note: important reading for anyone interested in gene therapy
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-8055-6828-9
    Language: English
    Subjects: Medicine
    RVK:
    XH 3239
    Keywords: Blutstammzelle ; Transduktion ; Arzneimittelresistenz ; Resistenzgen ; Cytostatikum ; Immunsuppression ; Granulozytopenie ; Blutstammzelle ; Gentransfer ; Arzneimittelresistenz ; Aufsatzsammlung
    DOI: 10.1159/isbn.978-3-318-00397-0
    URL: Volltext
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Online Access
    Open Access Request
    EUV Frankfurt
    TH Brandenburg
    TH Wildau
    TU Berlin
  • 4
    Online Resource
    Online Resource
    Marrow protection : transduction of hematopoietic cells with drug resistance renes ; important reading for anyone interested in gene therapy (1999)
    Basel : Karger
    Details
    UID:
    gbv_1672336104
    Format: Online-Ressource
    Edition: Karger eBooks Collection 1997-2009
    ISBN: 3805568282 , 9783805568289
    Series Statement: Progress in experimental tumor research 36
    Content: Authored by experts in the field, this volume provides a comprehensive review of the problems and opportunities in gene therapy focusing on the use of various drug resistance genes to provide protection of hematopoietic cells against drug toxicity.General topics include basic principles of gene transfer, optimizing conditions for gene transfer in hematopoietic cells, and gene transfer in the nonmyeloablated host. Specific chapters describe constructions and preclinical studies of specific genes that impart resistance to anticancer drugs when expressed in hematopoietic cells including MDR-1, mutated forms of human methylguanine-DNA-methyltranferase, mutant forms of dihydrofolate reductase and thymidylate synthase, dihydropyrimidine dehydrogenase and cytidine deaminase. For successful transfer of drug resistance genes, the possibility that they may be used as selectable markers and that marrow ablation may not be required are important considerations.This book is especially timely, as clinical trials with these drug resistance genes are expected to increase markedly in the next few years. It should appeal to all interested in stem cell biology and gene therapy, as well as clinicians who look forward to using this technology in their practice
    Note: Includes bibliographical references and indexes , ""Contents""; ""Preface""; ""Basic Principles of Gene Transfer in Hematopoietic Stem Cells""; ""Optimizing Conditions for Gene Transfer into Human Hematopoietic Cells""; ""Transfer of theMDR-1 Gene into Hematopoietic Cells""; ""O6-Benzylguanine-Resistant Mutant MGMT Genes Improve Hematopoietic Cell Tolerance to Alkylating Agents""; ""Use of Variants of Dihydrofolate Reductase in Gene Transfer to Produce Resistance toMethotrexate and Trimetrexate1""; ""Augmentation of Methotrexate Resistance with Coexpression of Metabolically Related Genes"" , ""Protection of BoneMarrow Cells from Toxicity of Chemotherapeutic Agents Targeted toward Thymidylate Synthase by Transfer ofMutant Forms of Human Thymidylate Synthase cDNA""""Dihydropyrimidine Dehydrogenase and Resistance to 5-Fluorouracil""; ""Chemoprotection against Cytosine Nucleoside Analogs Using the Human Cytidine Deaminase Gene""; ""In vivo Selection of Hematopoietic Stem Cells Transduced with DHFR-Expressing Retroviral Vectors""; ""In vivo Selection of GeneticallyModified Bone Marrow Cells""; ""Gene Transfer in the Nonmyeloablated Host""; ""Author Index""; ""Subject Index""
    Additional Edition: ISBN 9783318003970
    Language: English
    URL: lizenzpflichtig
    URL: Volltext
    Library Location Call Number Volume/Issue/Year Availability
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    Stabi Berlin
    UB Potsdam
    MPI Bildungsforschung
  • 5
    Online Resource
    Online Resource
    Clinical Ethics for Consultation Practice / (2022)
    Cham :Springer International Publishing, | Cham :Springer.
    Details
    UID:
    almafu_BV047636323
    Format: 1 Online-Ressource (XXVI, 162 p).
    Edition: 1st ed. 2022
    ISBN: 978-3-030-90182-0
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-90181-3
    Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-3-030-90183-7
    Language: English
    DOI: 10.1007/978-3-030-90182-0
    URL: Volltext  (URL des Erstveröffentlichers)
    URL: https://doi.org/10.1007/978-3-030-90182-0
    Library Location Call Number Volume/Issue/Year Availability
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    Online Access
    Open Access Request
    HU Berlin
    FU Berlin
    Charité
  • 6
    Book
    Book
    Folate antagonists as chemotherapeutic agents : [result of a Conference Entitled Folate Antagonists as Chemotherapeutic Agents, held by the New York Academy of Sciences on January 11 - 13, 1971] (1971)
    New York, NY : New York Academy of Sciences
    Details
    UID:
    gbv_237733005
    Format: 519 S. , Ill., graph. Darst.
    Series Statement: Annals of the New York Academy of Sciences 186
    Note: Literaturangaben
    Language: English
    Keywords: Konferenzschrift
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  • 7
    Online Resource
    Online Resource
    Marrow protection : transduction of hematopoietic cells with drug resistance genes (1999)
    Basel ; : Karger,
    Details
    UID:
    almafu_9958103967602883
    Format: 1 online resource (193 p.)
    ISBN: 3-318-00397-2
    Series Statement: Progress in experimental tumor research ; vol. 36
    Content: Authored by experts in the field, this volume provides a comprehensive review of the problems and opportunities in gene therapy focusing on the use of various drug resistance genes to provide protection of hematopoietic cells against drug toxicity. General topics include basic principles of gene transfer, optimizing conditions for gene transfer in hematopoietic cells, and gene transfer in the nonmyeloablated host. Specific chapters describe constructions and preclinical studies of specific genes that impart resistance to anticancer drugs when expressed in hematopoietic cells including MDR-1, mutated forms of human methylguanine-DNA-methyltranferase, mutant forms of dihydrofolate reductase and thymidylate synthase, dihydropyrimidine dehydrogenase and cytidine deaminase. For successful transfer of drug resistance genes, the possibility that they may be used as selectable markers and that marrow ablation may not be required are important considerations. This book is especially timely, as clinical trials with these drug resistance genes are expected to increase markedly in the next few years. It should appeal to all interested in stem cell biology and gene therapy, as well as clinicians who look forward to using this technology in their practice.
    Note: Description based upon print version of record. , ""Contents""; ""Preface""; ""Basic Principles of Gene Transfer in Hematopoietic Stem Cells""; ""Optimizing Conditions for Gene Transfer into Human Hematopoietic Cells""; ""Transfer of theMDR-1 Gene into Hematopoietic Cells""; ""O6-Benzylguanine-Resistant Mutant MGMT Genes Improve Hematopoietic Cell Tolerance to Alkylating Agents""; ""Use of Variants of Dihydrofolate Reductase in Gene Transfer to Produce Resistance toMethotrexate and Trimetrexate1""; ""Augmentation of Methotrexate Resistance with Coexpression of Metabolically Related Genes"" , ""Protection of BoneMarrow Cells from Toxicity of Chemotherapeutic Agents Targeted toward Thymidylate Synthase by Transfer ofMutant Forms of Human Thymidylate Synthase cDNA""""Dihydropyrimidine Dehydrogenase and Resistance to 5-Fluorouracil""; ""Chemoprotection against Cytosine Nucleoside Analogs Using the Human Cytidine Deaminase Gene""; ""In vivo Selection of Hematopoietic Stem Cells Transduced with DHFR-Expressing Retroviral Vectors""; ""In vivo Selection of GeneticallyModified Bone Marrow Cells""; ""Gene Transfer in the Nonmyeloablated Host""; ""Author Index""; ""Subject Index"" , English
    Additional Edition: ISBN 3-8055-6828-2
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    FU Berlin
    Charité
  • 8
    Online Resource
    Online Resource
    Cox-2 : a new target for cancer prevention and treatment (2003)
    Basel ; : Karger,
    Details
    UID:
    almafu_9958115836802883
    Format: 1 online resource (300 p.)
    ISBN: 3-318-00940-7 , 0-585-47197-5
    Series Statement: Progress in experimental tumor research ; v. 37
    Content: Numerous investigators have found increased levels of cyclooxygenase-2 (COX-2) in both pre-malignant and malignant tissues. Moreover, animals engineered to be COX-2 deficient or treated with a selective COX-2 inhibitor showed reduced tumor formation and growth. The present book reviews these findings suggesting that COX-2 is a valid molecular target for the prevention and treatment of cancer. The first chapters are devoted to the epidemiology of nonsteroidal anti-inflammatory drugs (NSAIDs) and cancer, the pharmacology of COX-2 inhibitors and the regulation of COX-2 expression in human cancers. Besides, the book contains a series of chapters examining the link between COX-2 and cancer in specific organs (e.g. skin, breast, cervix, digestive tract, lung, etc.). Furthermore, several clinical trials assessing the potential of COX-2 inhibitors for preventing and treating cancer are described. The final chapter provides an up-to-date consideration of COX-independent targets of NSAIDs and related compounds in cancer prevention and treatment. This state-of-the-art publication is recommended reading not only for medical and radiation oncologists, but also for pharmacologists, gastroenterologists and other subspecialists.
    Note: Description based upon print version of record. , ""Contents""; ""Preface""; ""Epidemiology of Non-Steroidal Anti- Inflammatory Drugs and Cancer""; ""Pharmacology of COX-2 Inhibitors""; ""Regulation of COX-2 Expression in Human Cancers""; ""Cyclooxygenase-2 and Skin Carcinogenesis""; ""The Role of COX-2 in Breast and Cervical Cancer""; ""Cyclooxygenase-2: A Target for the Prevention and Treatment of Cancers of the Upper Digestive Tract""; ""Cyclooxygenase-2 and Colorectal Cancer""; ""Cyclooxygenase-2 in Lung Cancer""; ""COX-2 Inhibitors and Other NSAIDs in Bladder and Prostate Cancer"" , ""Therapeutic Potential of Selective Cyclooxygenase- 2 Inhibitors in the Management of Tumor Angiogenesis""""Potential for Combined Modality Therapy of Cyclooxygenase Inhibitors and Radiation""; ""Non-Steroidal Anti-Inflammatory and Cyclooxygenase- 2- Selective Inhibitors in Clinical Cancer Prevention Trials""; ""Chemotherapy with Cyclooxygenase-2 Inhibitors in the Treatment of Malignant Disease: Pre- Clinical Rationale and Preliminary Results of Clinical Trials""; ""Role of COX-Independent Targets of NSAIDs and Related Compounds in Cancer Prevention and Treatment""; ""Author Index"" , ""Subject Index"" , English
    Additional Edition: ISBN 3-8055-7536-X
    Language: English
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    Online Resource
    FU Berlin
    Charité
  • 9
    Book
    Book
    Marrow protection : transduction of hematopoietic cells with drug resistance genes ; 21 tables (1999)
    Basel [u.a.] : Karger
    Details
    UID:
    gbv_268216185
    Format: VII, 184 S , Ill., graph. Darst , 25 cm
    ISBN: 3805568282
    Series Statement: Progress in experimental tumor research 36
    Note: Literaturangaben
    Language: English
    Subjects: Medicine
    RVK:
    XH 3239
    Keywords: Blutstammzelle ; Transduktion ; Arzneimittelresistenz ; Resistenzgen ; Aufsatzsammlung
    URL: Inhaltsverzeichnis
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  • 10
    Book
    Book
    Encyclopedia of cancer
    San Diego, Calif. [u.a.] : Academic Press
    Show associated volumes
    Details
    UID:
    gbv_282234195
    ISBN: 012093230X
    Note: Erschienen: 1 - 3
    Language: Undetermined
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