UID:
almahu_9948025472802882
Format:
1 online resource (311 p.)
ISBN:
1-281-03264-6
,
9786611032647
,
0-08-053239-X
Series Statement:
Biological Techniques Series
Content:
Computer access is the only way to retrieve up-to-date sequences and this book shows researchers puzzled by the maze of URLs, sites, and searches how to use internet technology to find and analyze genetic data. The book describes the different types of databases, how to use a specific database to find a sequence that you need, and how to analyze the data to compare it with your own work. The content also covers sequence phenotype, mutation, and genetic linkage databases; simple repetitive DNA sequences; gene feature identification; and prediction of structure and function of proteins from
Note:
Description based upon print version of record.
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Front Cover; Genetics Databases; Copyright Page; Contents; Chapter 1. Introduction; 1.1 Internet resources; 1.2 Organisms and proteins; 1.3 Phenotypes and genotypes; 1.4 Physical mapping; 1.5 Expression profiling; 1.6 Multiprotein complexes and pathways; 1.7 Sequence, structure and function; Chapter 2. Nucleic Acid and Protein Sequence Databases; 2.1 Introduction; 2.2 The main sequence databases; 2.3 Rate of database growth; 2.4 Problems with the data; 2.5 Accessing the databases; References; Chapter 3. Phenotype, Mutation and Genetic Linkage Databases and Their Links to Sequence Databases
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3.1 Introduction3.2 Levels of variation; 3.3 Definitions; 3.4 Types of databases; 3.5 Using mutation databases; 3.6 Exercises; 3.7 The HUGO mutation database initiative; 3.8 Conclusion; References; Chapter 4. DNA Composition, Codon Usage and Exon Prediction; 4.1 Introduction; 4.2 Measures dependent on a model of coding DNA; 4.3 Measures independent of a model of coding DNA; 4.4 Coding statistics in gene identification programs; References; Chapter 5. The Properties of Amino Acids in Sequences; 5.1 Introduction; 5.2 Properties of amino acids; 5.3 Empirically derived amino acid relationships
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5.4 Relationship to the genetic code5.5 Multiple sequence alignments; References; Chapter 6. Sequence Comparison; 6.1 Introduction; 6.2 Dotplots; 6.3 Alignments; 6.4 Motif-based approaches; 6.5 Conclusion; References; Chapter 7. Simple Repetitive Sequences in DNA Databanks; 7.1 Introduction; 7.2 Microsatellites in databases for population genetic analyses; 7.3 Genetic distances; 7.4 Population sizes and gene flow; 7.5 Tandem repeat block expansion diseases - a continuum from trinucleotides to minisatellites? Implications for database usage in population genetics; 7.6 Summary; References
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Chapter 8. Gene Feature Identification8.1 Introduction; 8.2 Biologically interesting sequences features; 8.3 Sequence analysis methods; 8.4 Computer programs, databases and WWW servers; 8.5 An example; References; Chapter 9. Multiple Sequence Alignment; 9.1 Introduction; 9.2 Selecting the sequences to align; 9.3 Automatic sequence alignment; 9.4 Using Clustal W and Clustal X; 9.5 Editing and viewing multiple alignments; References; Chapter 10. On-line Resources for RNA Science; 10.1 Introduction; 10.2 Specialized RNA-related databases; 10.3 Tools for analysis: RNA structure and prediction
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10.4 Future directionsReferences; Chapter 11. Predicting the Evolution, Structure and Function of Proteins from Sequence Information; 11.1 Introduction; 11.2 Protein evolution and function; 11.3 Protein structure and function; 11.4 Functions of enzymatic and regulatory domains; 11.5 Classical genetics and protein functions; 11.6 Summary; References; Chapter 12. Structural Databases; 12.1 Introduction; 12.2 The Brookhaven Protein Data Bank; 12.3 The Cambridge Structural Database; 12.4 BioMagResBank; 12.5 The Nucleic Acid Database; 12.6 A typical PDB entry
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12.7 Protein structure classification resources
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English
Additional Edition:
ISBN 0-12-101625-0
Language:
English
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