UID:
almahu_9948025552102882
Format:
1 online resource (323 pages) :
,
illustrations
ISBN:
1-281-07677-5
,
9786611076771
,
0-08-053454-6
Series Statement:
Handbook of immunopharmacology. Cells and mediators
Content:
Free radicals have been implicated in a entire host of different human disease states, which suggests that although they may not have a pivotal causal role, they are involved in the perpetuation of disease. In recent years, it has become evident that although free radicals most certainly do have this role in perpetuating inflammatory reactions, they have perhaps a far more important role in acting as second messenger systems to maintain normal cell function. It is the perturbations of these reactions which pose the most intriguing therapeutic challenges.
Note:
Front Cover; Immunopharmacology of Free Radical Species; Copyright Page; Contents; Contributors; Series Preface; Preface; Chapter 1. Methods for the Detection and Measurement of Reactive Radical Species in vivo and in vitro; 1. Introduction; 2. Direct Observation of Free-radical Species in Biological Samples by Electron Spin Resonance Spectroscopy; 3. Detection of Protein Damage Arising from the Action of Oxygen-derived Radical Species; 4. DNA Damage; 5. Oxidative Damage to Carbohydrates
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6. Analysis of Products Arising from the Interactions of Reactive Oxygen Species with Further Biomolecules of Low Molecular Mass; 7. Detection of Products Arising from the Radical-mediated Peroxidation of Polyunsaturated Fatty Acids; 8. Conclusions; 9. Acknowledgements; 10. References; Chapter 2. Lipid Peroxidation and Cardiovascular Disease; 1. Introduction; 2. Mechanisms of Lipid Peroxidation; 3. Cell Culture Models of Lipoprotein Oxidation; 4. Summary; 5. References; Chapter 3. Free Radicals and Antioxidants in Atherosclerosis; 1. Introduction
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2. The Possible Mechanisms of the Oxidation of LDL in the Production of Lipid Hydroperoxides; 3. Antioxidants and their Actions; 4. The Involvement of Free Radicals in the Pathogenesis of Atherosclerosis; 5. Oxidized LDL - Is It a Reality?; 6. Acknowledgements; 7. References; Chapter 4. Oxidant Stress and the Heart: Modulation of Ion Transport Mechanisms during Ischaemia and Reperfusion; 1. Reperfusion of the Heart and Oxidant Stress; 2. How the Heart Copes with Oxidant Stress; 3. Membrane Consequences of Oxidant Stress; 4. Oxidant Stress, Redox State and Protein Function
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5. Molecular Mechanism of Oxidant Stress-induced Modifications of Protein Function; 6. Summary and Conclusions; 7. Acknowledgement; 8. References; Chapter 5. Free Radicals in Central Nervous System Diseases; 1. Evidence for the Existence of Free Radicals in the Brain; 2. Sources of Free Radicals; 3. Defences against Free Radical Attack; 4. Evidence for a Role for Free Radicals in CNS Diseases; 5. Protective Effects of Antioxidants; 6. Summary; 7. References; Chapter 6. Renal Transplantation and Ischaemia-Reperfusion Injury; 1. The Clinical Problem; 2. Renal Ischaemia
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3. Current Methods of Renal Preservation; 4. Presumed Mechanisms of Ischaemic Damage; 5. Oxidative Stress; 6. Delocalization of Iron; 7. Loss of Calcium Homeostasis; 8. Second Messengers; 9. Respiratory Chain Dysfunction; 10. Conclusions; 11. References; Chapter 7. A Vascular Basis for Free Radical Involvement in Inflammatory Joint Disease; 1. Introduction; 2. Mechanisms, Antioxidant Defences and Consequences of Free-radical Production in the Rheumatoid Joint; 3. Lipid Abnormalities in Inflammatory Joint Disease; 4. Formation of ox-LDL in the Inflamed Human Joint; 5. Potential Pro-inflammatory Influences of ox- LDL in RA
,
English
Additional Edition:
ISBN 0-12-103520-4
Language:
English
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