Kooperativer Bibliotheksverbund

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Format: 211 S. : Ill.

ISBN: 3-7643-5236-1

Uniform Title: Dead men do tell tales

Language: German

Subjects: Medicine

Keywords: Rechtsmedizin ; Anthropologie ; Kriminalfall ; Rechtsmedizin ; Erlebnisbericht ; Erlebnisbericht. ; Anthropologie ; Kriminalfall ; Rechtsmedizin ; USA

URL: Inhaltsverzeichnis

URL: Rezension

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Format: X, 311 p. 100 illus., 30 illus. in color. , online resource.

Edition: 1st ed. 2024.

ISBN: 9783031663567

Series Statement: Current Topics in Behavioral Neurosciences, 66

Content: This volume is unique in bringing the exciting range of antidepressant treatment developments together with a focus on their neurobiological mechanisms and how these interact with the known pathophysiology of depression. Current evidence for treatment efficacy is reviewed together with a discussion of where in the management pathway of this common condition, these new approaches might take their place.

Note: SSRIs A pharmacological cul-de-sac -- Neurobiology of SSRI withdrawal -- Pramipexole in the treatment of depression -- Opioid mechanisms in the treatment of depression -- Neuropsychological effects of antidepressants-translational studies -- KETAMINE FOR MAJOR DEPRESSIVE DISORDER -- Psilocybin and other classic psychedelics in depression -- Gut-brain axis and antidepressant treatment -- Anti-inflammatory drugs in the treatment of depression -- Mechanisms of TMS in Depression -- Mechanism of action of ECT in depression -- Vagal nerve stimulation in the treatment of depression.

In: Springer Nature eBook

Additional Edition: Printed edition: ISBN 9783031663550

Additional Edition: Printed edition: ISBN 9783031663574

Additional Edition: Printed edition: ISBN 9783031663581

Language: English

DOI: 10.1007/978-3-031-66356-7

URL: https://doi.org/10.1007/978-3-031-66356-7

URL: Volltext  (URL des Erstveröffentlichers)

URL: lizenzpflichtig

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Format: 1 Online-Ressource (214 S.)

ISBN: 9783034850896 , 9783034850902

Note: Im Gegensatz zu Gerichtsmedizinern arbeiten Forensische Anthropologen nahezu ausschliesslich am Skelett. Sie verfügen über eine aussergewöhnliche Begabung: anhand eines Skeletts oder auch nur einzelner Knochen können sie Alter, Geschlecht, Herkunft und Todesart des Opfers bestimmen. In Knochengeflüster beschreibt William Maples seine vielseitige Arbeit, beispielsweise die Exhumierung der Zarenfamilie und die Aufklärung eines fünffachen Mordes in Florida. Maples' Leben gleicht einem Krimi: ständig ist er von Mord und Selbstmord umgeben, konfrontiert mit den Opfern. Er selbst bezeichnet sich als "Knochenleser", jemanden, der das "Flüstern des Todes" hört und versteht. Es mag paradox und vielleicht makaber klingen, doch Maples' Buch ist ein lebendig geschriebener Erlebnisbericht, ein begeistertes Plädoyer für die forensische Anthropologie. Patricia Cornwell, die Autorin der erfolgreichen Bücher über die Gerichtsmedizinerin Kay Scarpetta, schreibt zu diesem Buch: "Knochengeflüster ist ein Meisterwerk!"

Language: German

Keywords: USA ; Rechtsmedizin ; Anthropologie ; Kriminalfall ; National Museum of Natural History ; Rechtsmedizin ; Erlebnisbericht ; Erlebnisbericht

DOI: 10.1007/978-3-0348-5089-6

URL: Volltext

URL: Volltext

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Format: 1 Videokassette (98 Min.)

Content: as als romantischer Urlaub beginnt entwickelt sich zu einem Abenteuer ohnegleichen.

Language: German

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Format: 270 S.

Language: German

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Format: 1 DVD, 111 Min. : farb.

Uniform Title: Bad Company

Content: Die Welt ist in guten Händen. - CIA-Agent Gaylord Oakes ist erfahrener Profi auf dem Gebiet der Spionage. Bei dem Versuch, einen Atomwaffendeal abzuschließen und sich als internationaler Waffenhändler in die Organisation einzuschleichen, wird Oakes Kollege Pope erschossen, ohne den der Deal platzen würde. Die einzige Chance des CIA, doch noch an die Atombombe zu kommen, ist Pope's Zwillingsbruder. Allerdings weiß der noch gar nicht, dass er einen Bruder hatte, und obwohl er ihm wie aus dem Gesicht geschnitten ist, hat er ansonsten kaum Ähnlichkeit mit seinem eiskalt-professionellen Zwilling. Deswegen soll Jake in einem 9-Tage-Crashkurs in kürzester Zeit zu einem knallharten CIA-Agenten ausgebildet werden ...

Note: Orig.: USA, 2002. - Nach e. Geschichte von Gary Goodman u. David Himmelstein. - Inkl. Special Features

Language: German

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Format: 98 Min.

Language: German

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Format: 266 S. : Fot.

ISBN: 3453148479

Language: German

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Format: 1 online resource (314 pages)

Edition: 1st ed.

ISBN: 3-031-66356-X

Series Statement: Current Topics in Behavioral Neurosciences Series ; v.66

Note: Intro -- Preface -- Contents -- SSRIs in the Treatment of Depression: A Pharmacological CUL-DE-SAC? -- 1 Depression and Antidepressant Treatment -- 2 Development of SSRIs -- 3 Advantages of SSRIs -- 3.1 Simplicity of Dosing -- 3.2 Efficacy Against Anxiety Symptoms -- 3.3 Relative Safety in Overdose -- 4 Problems with SSRIs -- 4.1 Delayed Onset of Action -- 4.2 Limited Efficacy -- 4.3 Suicidality -- 4.4 Increased Anxiety Early in Treatment -- 4.5 Sleep Problems -- 4.6 Sexual Dysfunction -- 4.7 Emotional Blunting -- 4.8 Cognitive Impairment -- 4.9 Withdrawal Symptoms -- 5 Modifications of Selective Serotonin Reuptake Inhibition as a Therapeutic Mechanism -- 5.1 Dual Reuptake Inhibitors -- 5.2 Serotonin Reuptake Inhibition and Serotonin Receptor Activity -- 6 Other Potential Serotonin Receptor Sub-type Mechanisms -- 6.1 5-HT2A/2C Receptor Blockade -- 6.2 5-HT4 Receptor Agonism -- 6.3 5-HT7 Receptors -- 7 Conclusions -- References -- Mechanisms of SSRI Therapy and Discontinuation -- 1 SSRI Benefits and Adverse Effects -- 2 Mechanisms of SSRI Action -- 2.1 Importance of the 5-HT Transporter -- 2.2 Neuroadaptive Changes in 5-HT Neuron Function -- 2.3 Role of Adaptive Changes in Neural Plasticity -- 2.4 Rapid Acting Antidepressants -- Ketamine and Psychedelic Drugs -- 2.5 Depression Pathophysiology -- 2.6 A Neuropsychological Perspective of SSRI Action -- 3 SSRI Discontinuation -- 3.1 SSRI Discontinuation Syndrome -- 3.2 `Discontinuation´ vs. `Withdrawal´ -- 3.3 Discontinuation Risk Factors -- 3.4 Modelling SSRI Discontinuation in Animals -- 4 Mechanisms of SSRI Discontinuation -- 4.1 Role of 5-HT -- 4.2 Causal Link between 5-HT Changes and Behaviour -- 4.3 A Role for Other Neurotransmitter Systems -- 4.4 Mechanisms Underpinning Other Drug Withdrawal States -- 5 Conclusion -- References. , Pramipexole for the Treatment of Depression: Efficacy and Mechanisms -- 1 Dopaminergic Treatments in Depression -- 2 Pharmacology of Pramipexole -- 3 Pramipexole, an Emerging Treatment for Major Depression? -- 3.1 Efficacy in Randomised Trials -- 3.2 Efficacy in Case Series -- 4 The Neural Architecture of Reward Learning -- 4.1 Neural Circuitry -- 4.2 Computational Accounts of Reward Learning -- 5 Reward Learning in Depression -- 6 Pramipexole and Reward Processing -- 7 Pramipexole Preserves Value Estimates -- 8 Conclusions -- References -- Opioid Mechanisms and the Treatment of Depression -- 1 Introduction -- 2 The Endogenous Opioid System -- 3 The Opioid System and Depression -- 4 Opioidergic Agents in Depression -- 5 Antidepressant Mechanisms of Opioid System Engagement -- 5.1 Monoaminergic Systems -- 5.2 Regulation of the Stress Response and the Hypothalamic-Pituitary-Adrenal (HPA) Axis -- 5.3 Immune System and Inflammation -- 5.4 Brain-Derived Neurotrophic Factor (BDNF) -- 5.5 Intracellular Signalling, Neurogenesis and Neuroplasticity -- 5.6 Opioid System and the Social Brain: Social Pain and Social Reward -- 5.7 Expectancy and Placebo Effects -- 6 Conclusions -- References -- Neuropsychological Effects of Antidepressants: Translational Studies -- 1 Introduction -- 2 The Role of Animal Models in Research into Antidepressant Mechanisms -- 3 Neuropsychological Impairments in Mood Disorders -- 4 Neuropsychological Effects of Antidepressants: Healthy Volunteer and Patient Studies -- 5 Neuropsychological Effects of Antidepressants: Animal Studies -- 6 Animal Models of Reward Learning -- 7 Discussion and Conclusions -- 7.1 Could Different Neuropsychological Effects of Conventional Versus Rapid Acting Antidepressants Explain the Temporal Differ... -- 7.2 Possible Neural Circuits Mediating Affective Biases -- 7.3 Summary and Future Directions. , References -- Ketamine for Major Depressive Disorder -- 1 Introduction -- 2 Beyond the Monoaminergic Hypothesis of Depression -- 3 Clinical Effects of a Single Administration of a Sub-anaesthetic Dose of Ketamine -- 4 How to Extend Ketamine Antidepressant Effect? -- 5 Ketamine and Suicidality -- 6 Ketamine Assisted Psychotherapy -- 7 Ketamine Safety Profile -- 8 Pharmacology of Ketamine -- 8.1 Pharmacokinetics and Route of Administration -- 8.2 Ketamine Molecular Mechanism of Action -- 9 Brain-Imaging Biomarkers of Ketamine Antidepressant Effects -- 9.1 Resting State Functional Magnetic Resonance Imaging (fMRI) Studies -- 9.2 Positron Emission Tomography (PET) Studies -- 9.3 Task-Based fMRI Studies -- 10 Conclusion -- References -- Psilocybin and Other Classic Psychedelics in Depression -- 1 Introduction -- 2 Basic Facts -- 3 Clinical Effects -- 3.1 Psychological Processes -- 4 Brain Mechanisms -- 4.1 Magnetic Resonance Imaging -- 4.2 Electroencephalography -- 4.3 Computational Aspects of Psychedelics in Depression -- 5 Current Research Questions -- 5.1 Duration of Trip for Psychedelics: Why Does This Matter? -- 5.2 Optimal Number of Treatments -- 5.3 Prior Antidepressant Treatment -- 5.4 Psychedelics and Prophylaxis -- 5.5 Can Psychedelics Be Developed that Treat Depression Without Having a Psychedelic Effect? -- 5.6 Legality of Psychedelics -- 6 Final Thoughts -- References -- Microbiota-Gut-Brain Axis and Antidepressant Treatment -- 1 Introduction -- 2 The Gut Microbiota -- 3 Microbiota-Gut-Brain Axis -- 4 Microbiota-Gut-Brain Axis, Brain Function, and Behavior -- 5 Updates to the Pathogenesis and Neurobiology of Depression: A Multifactorial Contribution -- 6 The Microbiome-Gut-Brain Axis and Depression -- 7 Conventional Antidepressant Therapy -- 8 Antidepressants and the Microbiota-Gut-Brain Axis -- 9 Prebiotics and Probiotics. , 10 Future Directions -- References -- Anti-inflammatory Drugs in the Treatment of Depression -- 1 Immune-Mediated Inflammation in the Neurobiology of Depression -- 1.1 General Background -- 1.2 Genetic Data -- 1.3 Epigenetics -- 1.4 Cell Biology in Depression -- 1.4.1 Cell Populations -- 1.4.2 Peripheral -- 1.4.3 Transcriptional Differences -- 1.4.4 Cells Within the CNS -- 1.5 Cellular Mechanisms: The Inflammasome -- 1.6 Adiposity and Aging -- 2 Evidence for the Antidepressant Effects of Anti-inflammatory Medication -- 2.1 Drug Types -- 2.2 Meta-Analytic Data of Drug Effects -- 2.2.1 Meta-Analyses Studies with Depression as a Secondary Measure -- 3 The (Possible) Antidepressant Mechanism of Anti-inflammatory Drugs -- 3.1 Glutamate -- 3.2 Serotonin -- 3.3 IDO and the Kynurenine Pathway -- 3.4 Measuring Mechanism in Clinical Studies -- 4 Future -- 5 Conclusions -- References -- Mechanisms of Action of TMS in the Treatment of Depression -- 1 Introduction -- 2 Neuroanatomical Targets for TMS in Depression -- 2.1 Correlational Mapping of Target Brain Regions for Depression -- 2.2 Causal Mapping of Whole-Brain Networks for Depression -- 3 Functional Connectivity and Therapeutic Effects of TMS in Depression -- 3.1 Characterizing Changes in Functional Connectivity Associated with Response to DLPFC-TMS -- 3.2 Non-DLFPC TMS Targets in Depression: Common or Distinctive Mechanisms? -- 4 Synaptic and Neuroplastic Mechanisms of TMS in Depression -- 4.1 TMS Effects on Plasticity in Local Microcircuits -- 4.2 TMS Effects on Plasticity in Distributed Networks -- 4.3 Modeling TMS in Rodents -- 5 Neuropharmacological Mechanisms of TMS in Depression -- 5.1 Dopaminergic Mechanisms -- 5.2 Glutamatergic Mechanisms -- 6 Unresolved Questions on the Mechanisms of TMS in Depression -- 6.1 Where Are All the TMS `Anti-responders´?. , 6.2 Why Are TMS Clinical Outcomes Not as Heterogeneous as TMS Single-Session Effects? -- 6.3 What Are the Implications of Meta-Plasticity for Therapeutic TMS Protocols? -- 6.4 Synaptic Pro-Kurtosis (SPrK) as a Therapeutic Mechanism for TMS -- 6.5 Implications of the SPrK Model for Interpreting the Neuropathology of Psychiatric Disorders -- 7 Transdiagnostic and Evolutionary Perspectives on the Mechanisms of TMS in Depression -- 8 Summary and Conclusions -- References -- Mechanism of Action of ECT in Depression -- 1 Introduction -- 2 Volumetric Brain Changes -- 3 Structural Connectivity Changes -- 4 Functional Connectivity Changes -- 5 Immune Effects -- 6 Conclusion -- References -- Invasive Neuromodulation Techniques for Treatment-Resistant Depression -- 1 Introduction -- 2 Vagal Nerve Stimulation -- 2.1 Mechanism of Action -- 2.2 Clinical Experience -- 2.3 Conclusions and Future Directions -- 3 Deep Brain Stimulation -- 3.1 Subcallosal Cingulate Gyrus (SCG) -- 3.2 Other DBS Targets -- 3.3 Conclusions -- 4 Epidural Cortical Stimulation -- 5 Conclusions -- References.

Additional Edition: ISBN 3-031-66355-1

Language: English

UID:

Format: 1 Videokass. (ca. 98 Min.)

Edition: 1

Note: Dt.

Language: German

Author information: Ford, Harrison