Kooperativer Bibliotheksverbund

UID:

Format: 1 online resource (182 pages) : , color illustrations, photographs, graphs

ISBN: 0-323-54426-6 , 0-323-54425-8

Note: Front Cover -- Chronic Traumatic Encephalopathy -- Chronic Traumatic Encephalopathy -- Copyright -- Contributors -- Foreword -- Preface -- Acknowledgments -- Contents -- 1 - History of Concussion and Chronic Traumatic Encephalopathy -- INTRODUCTION -- HISTORICAL THEORIES OF CONCUSSION -- Theories of Concussion -- Definitions of Concussion -- Centripetal Theory of Concussion -- Loss of Consciousness -- Researchers of Concussions and Their Sequelae -- CURRENT UNDERSTANDING OF CONCUSSION -- Forces Needed to Produce Concussion -- Current Definition of Concussion -- CONCUSSION IN ATHLETES -- Grading the Severity of Concussions -- Return-to-Play Guidelines -- Toward a Definition of Concussion -- Mechanically Induced Concussion Symptoms -- Current Definitions of Concussion -- CHRONIC TRAUMATIC ENCEPHALOPATHY IN ATHLETES -- CTE in Boxers -- Early Recognition in Football Players -- The Boston University Team Working to Understand CTE -- CTE Has Been Found in Many Contact Sports -- Unforgotten: The Paul Pender Story -- THE FUTURE OF CONCUSSION AND CTEIN ATHLETES -- Important Questions to Be AnsweredAbout CTE -- Increasing Recognition of CTE -- DISCLOSURES -- REFERENCES -- FURTHER READING -- 2 - Pathology of Chronic Traumatic Encephalopathy -- INTRODUCTION -- CTE IS COMMON IN CONTACT SPORT ATHLETES -- PATHOLOGIC FEATURES OF CTE -- The Physics of Brain Injury Determines the Location of Pathology -- Consensus Criteria Established -- Consensus Criteria Independently Verified -- CTE Spreads Through the Brain Even After the Trauma Has Stopped -- Stages of CTE -- Young Individuals With CTE -- CTE in Football Players From Ages 40 to 82 -- CTE in Other Sports -- CRITICAL QUESTIONS IN CTE -- How Common Is CTE? How Many People Have It? -- How Can We Diagnose CTE During Life? -- Could Anybody Get CTE? Or Are There Genetic Susceptibility Factors?. , Are Young Brains More Susceptible to CTE? What About Women? -- How Does CTE Start in the Brain? -- Once CTE Is Started, How Does It Spread in the Brain Even in the Absence of Trauma? -- Does Trauma or CTE Provoke Other Neurodegenerations Like Alzheimer's and Parkinson's Diseases? -- What Are the Treatments for CTE? -- SUMMARY -- DISCLOSURES -- REFERENCES -- FURTHER READING -- 3 - Chronic Traumatic Encephalopathy: Clinical Presentation and Diagnostic Criteria -- INTRODUCTION -- CTE: WHAT WE NEED TO KNOW -- HISTORY AND ANTHROPOLOGY OF REPETITIVE HEAD IMPACTS -- LONG-TERM CONSEQUENCES OF REPETITIVE HEAD IMPACT EXPOSURE -- DIAGNOSIS OF CTE DURING LIFE: THE CRITICAL NEXT STEP -- Clinical Presentation of CTE: Retrospective Postmortem Data -- TRAUMATIC ENCEPHALOPATHY SYNDROME -- Case Example A -- Case Example B -- NEED FOR OBJECTIVE IN VIVO BIOMARKERS -- Diagnosing and Evaluating Traumatic Encephalopathy Using Clinical Tests -- Preliminary biomarker findings -- DIAGNOSE CTE RESEARCH PROJECT -- Diagnose CTE Research Project: Methods and Specific Aims -- CONCLUDING REMARKS -- REFERENCES -- 4 - Biomechanics of Head Trauma -- INTRODUCTION -- ACCELERATION-BASED BRAIN INJURY -- WAYNE STATE TOLERANCE CURVE -- BRAIN INJURY BIOMECHANICS -- CONCUSSIVE IMPACTS IN FOOTBALL -- CONCUSSIVE IMPACTS IN YOUNGER AGES -- TOWARD REDUCING CONCUSSIVE IMPACTS IN ATHLETES -- REFERENCES -- 5 - Mechanisms of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy: Acute and Chronic Effects of Blast Exposure -- INTRODUCTION -- DEFINITIONS -- CTE IN BLAST AND IMPACT INJURY -- BLAST NEUROTRAUMA MOUSE MODEL -- CHANGE IN HEAD ACCELERATION IS THE KEY -- Blast Exposure Triggers Microscopic CTE Pathology but Not Macroscopic Injury -- Changes in Brain Physiology -- Relating the Mouse Model to Human Disease -- CONCLUSIONS: PUTTING IT ALL TOGETHER -- DISCLOSURES -- REFERENCE. , 6 - Family Panel Discussion -- 7 - Genetics of Chronic Traumatic Encephalopathy -- INTRODUCTION -- WHY GENETICS MAY BE IMPORTANT FOR CTE -- METHODOLOGIES -- Choosing Controls -- Endophenotypes -- Repetitive Head Impacts Exposure Metrics -- Gene by Environment Interactions -- Epigenetics -- IMPLICATED GENES -- APOE -- MAPT Haplotype -- FUTURE DIRECTIONS -- ETHICS OF GENETIC TESTING -- CONCLUDING REMARKS -- REFERENCES -- FURTHER READING -- 8 - Comorbid Pathology in Chronic Traumatic Encephalopathy -- OVERVIEW OF COMORBID PATHOLOGIES SEEN IN CHRONIC TRAUMATIC ENCEPHALOPATHY -- COMPARISON OF PROGRESSION OF TAU PATHOLOGY IN CTE AND AD -- Β-AMYLOID IN CTE -- Age-Dependent Aβ Deposition -- Association of Aβ With CTE Stage and Tauopathy -- Association of Aβ With Dementia and Parkinsonism -- MODELING THE PATHOLOGY -- CONCLUSIONS -- REFERENCES -- 9 - Differential Diagnosis and Treatment of Chronic Traumatic Encephalopathy -- INTRODUCTION -- ALZHEIMER'S DISEASE IS THE MOST COMMON CAUSE OF DEMENTIA -- Diagnosis of Alzheimer's Disease Dementia -- Check vitamin D along with B12 and thyroid function -- Criteria for dementia and major neurocognitive disorder -- Criteria for Alzheimer's disease dementia -- Biomarkers and the continuum of Alzheimer's disease -- Biomarkers in clinical practice -- TREATMENT OF ALZHEIMER'S DISEASE DEMENTIA -- Cholinesterase Inhibitors -- Goals of Treatment -- Turning the Clock Back on Memory Loss -- Continue Cholinesterase Inhibitors as Long as There Is Function to Preserve -- Memantine for Moderate to Severe Dementia -- MILD COGNITIVE IMPAIRMENT -- Diagnostic Criteria for Mild Cognitive Impairment -- Prognosis of Mild Cognitive Impairment -- Treatment of Mild Cognitive Impairment -- DEMENTIA WITH LEWY BODIES -- VASCULAR DEMENTIA -- NORMAL-PRESSURE HYDROCEPHALUS -- FRONTOTEMPORAL DEMENTIA -- TREATING FRONTAL LOBE SYMPTOMS. , Pseudobulbar Affect -- Agitation -- CHRONIC TRAUMATIC ENCEPHALOPATHY -- Structural Imaging in CTE -- Functional Imaging in CTE -- Clinical Diagnosis of Probable CTE -- Pharmacological Treatment of Patients With Possible CTE -- Nonpharmacological Treatment of Patients With Possible CTE -- DISCLOSURES -- REFERENCES -- 10 - Fluid Biomarkers for Mild Traumatic Brain Injury and Chronic Traumatic Encephalopathy -- INTRODUCTION -- CEREBRAL SPINAL FLUID BIOMARKERS -- Acute TBI -- Boxers -- Window of Vulnerability Hypothesis -- Soccer Players -- BLOOD-BASED BIOMARKERS -- S-100B -- Single-Molecule Array in Serum and Plasma -- Plasma Tau in Ice Hockey Players -- Plasma Tau as a Marker for Concussion in Boxers -- Measuring Neurofilament Light in Serum and Plasma -- Serum Neurofilament Light and S-100B in Patients With Acute, Severe TBI -- Serum Neurofilament Light in Amateur Boxers -- BIOMARKERS FOR POSTCONCUSSIVE SYNDROME -- Hockey Players -- BIOMARKERS FOR REPETITIVE HEAD INJURY -- Plasma Total Tau in National Football League Players -- Exosomal Tau in National Football League Players -- Neurofilament Light in National Football League Players -- THE TIME COURSE OF CHANGE IN PLASMA BIOMARKERS IS KEY -- DISCLOSURES -- REFERENCES -- 11 - Toward Imaging Chronic Traumatic Encephalopathy -- OVERVIEW -- BACKGROUND -- IN VIVO BRAIN IMAGING FINDINGS IN FORMER NFL PLAYERS -- Cortical Atrophy and Cavum Septum Pellucidum -- Volumes of Hippocampus, Amygdala, Cingulate Gyrus, and Thalamus -- Basic Principles of Diffusion Tensor Imaging -- Repetitive Head Trauma and Possible Effects of Age at First Exposure to Trauma -- BRAIN IMAGING FINDINGS IN VIVO IN PROFESSIONAL SOCCER PLAYERS -- REPETITIVE HEAD IMPACTS IN UNIVERSITY HOCKEY PLAYERS -- ADVANCED IMAGING MEASURES FOR USE IN THE DIAGNOSE U01 GRANT -- Introduction -- PET Imaging Using β-Amyloid and Tau Ligands. , Free-Water Imaging -- Subject-Specific Analyses: Precision Medicine Approach -- Beyond Diffusion Tensor Imaging -- SUMMARY AND CONCLUSIONS -- DISCLOSURE -- REFERENCES -- 12 - From Chronic Traumatic Encephalopathy Biomarkers to Therapeutics: What We Need to Know to Design Clinical Trials -- INTRODUCTION -- TERMINOLOGY -- Endophenotypes -- Biomarkers -- Types of Studies -- MICROVASCULAR INJURY -- Cerebral Microcirculation and the Neurovascular Unit -- Diffuse Vascular Injury After TBI -- Response of Cerebral Microvasculature to TBI -- In Vivo Imaging of Cerebral Microvasculature in Response to TBI -- PHASE II STUDY: SILDENAFIL FOR CEREBROVASCULAR DYSFUNCTION IN CHRONIC TRAUMATIC BRAIN INJURY -- Mechanism of Sildenafil -- Design of the Phase II Study -- Participant Demographics -- Assessment of Vessel Reactivity With CO2 -- Assessment of Cerebral Blood Flow Using Arterial Spin Labeling and Cerebrovascular Reactivity Using Hypercapnia BOLD MRI -- Single-Dose Sildenafil in Patients With Chronic TBI and Healthy Controls -- FUNCTIONAL NEAR-INFRARED SPECTROSCOPY -- CONCLUSIONS -- REFERENCES -- 13 - Athlete Panel Discussion -- THE CONCUSSION LEGACY FOUNDATION -- INTRODUCTION OF THE PANEL -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W.

Language: English

UID:

Format: 1 online resource (xviii, 258 pages) : , illustrations (chiefly color)

Edition: Second edition.

ISBN: 0-323-31610-7

Uniform Title: Memory loss

Content: Now presented in full color, this updated edition of Memory Loss, Alzheimer's Disease, and Dementia is designed as a practical guide for clinicians that delivers the latest treatment approaches and research findings for dementia and related illnesses. Drs. Budson and Solomon - both key leaders in the field - cover the essentials of physical and cognitive examinations and laboratory and imaging studies, giving you the tools you need to consistently make accurate diagnoses in this rapidly growing area. Access in-depth coverage of clinically useful diagnostic tests and the latest treatment appr

Note: Preceded by: Memory loss : a practical guide for clinicians / Andrew E. Burton, Paul R. Solomon. [2011]. , Why diagnose and treat memory loss, Alzheimer's disease, and dementia? -- Evaluating the patient with memory loss or dementia -- Approach to the patient with memory loss, mild cognitive impairment, or dementia -- Alzheimer's disease dementia and mild cognitive impairment due to Alzheimer's disease -- Dementia with Lewy bodies (including Parkinson's disease dementia) -- Vascular dementia and vascular cognitive impairment -- Primary progressive aphasia and apraxia of speech -- Frontotemporal dementia -- Progressive supranuclear palsy -- Corticobasal degeneration -- Normal pressure hydrocephalus -- Jakob-Creutzfeldt disease -- Chronic traumatic encephalopathy -- Other disorders that cause memory loss or dementia -- Goals for the treatment of memory loss, Alzheimer's disease, and dementia -- Cholinesterase inhibitors -- Memantine (generic and Namenda XR) -- Vitamins, herbs, supplements, and anti-inflammatories for memory loss, Alzheimer's disease, and dementia -- Future treatments of memory loss, Alzheimer's disease, and dementia -- Non-pharmacological treatment of memory loss, Alzheimer's disease, and dementia -- Evaluating the behavioral and psychological symptoms of dementia -- Caring for and educating the caregiver -- Non-pharmacological treatment of the behavioral and psychological symptoms of dementia -- Pharmacological treatment of the behavioral and psychological symptoms of dementia -- Life adjustments for memory loss, Alzheimer's disease, and dementia -- Legal and financial issues in memory loss, Alzheimer's disease, and dementia -- Special issues in memory loss, Alzheimer's disease, and dementia -- Cognitive test and questionnaire forms, instructions, and normative data for evaluating memory loss, Alzheimer's disease, and dementia -- Screening for memory loss, Alzheimer's disease, and dementia -- Memory dysfunction in Alzheimer's disease and other causes of mild cognitive impairment and dementia. , English

Additional Edition: ISBN 0-323-31611-5

Additional Edition: ISBN 0-323-28661-5

Language: English

UID:

Format: 1 online resource (347 p.)

ISBN: 1-4377-3779-X

Content: Memory Loss combines expert guidance, case studies, and diagnostic tests to help you effectively diagnose Alzheimer's disease and other common dementias. Drs. Andrew E. Budson and Paul R. Solomon cover the essentials of physical and cognitive examinations, laboratory and imaging studies, and the latest treatment approaches. The practical text, diagnostic tests, and online access to a downloadable image bank at www.expertconsult.com are the tools you need to consistently make accurate diagnoses. Access the fully searchable text online at expertconsult.com, along with a downloadabl

Note: "Expert consult." , Front Cover; Memory Loss: A Practical Guide for Clinicians; Copyright; Contents; Foreword; Preface; How to use this book; Reference; References; References; Acknowledgments; Disclosures; About the Authors; Section I: Evaluating the Patient with Memory Loss; Chapter 1: Why diagnose and treat?; Helping the patient; Helping the family or other caregiver; Saving money; Planning for the future; Quality versus quantity; References; Chapter 2: Evaluating the patient with memory loss; Talking with the family; In the clinic , Formulating a treatment plan for behavioral and psychological symptoms: pragmatic guidelines for the clinicianAt the bedside; History; Review of systems; Medical history; Allergies to medications; Social history; Family history; Physical examination; Cognitive tests and questionnaires; Screening in the clinic; Laboratory studies; Structural imaging studies; Functional imaging studies; Summary; References; Section II: Differential Diagnosis of Memory Loss; Chapter 3: Alzheimer ́s disease; Prevalence, prognosis, and definition; Diagnostic criteria; Risk factors, pathology, and pathophysiology , Common signs, symptoms, and stagesThings to look for in the history; Things to look for on the physical and neurological examination; Pattern of impairment on cognitive tests; Laboratory studies; Structural imaging studies; Functional imaging studies; Differential diagnosis; Treatments; References; Chapter 4: Mild cognitive impairment; Prevalence, prognosis, and definition; Diagnostic Criteria; Common mild cognitive impairment scenarios; Risk factors, pathology, and pathophysiology; Common signs, symptoms, and stages; Things to look for in the history , Things to look for on the physical and neurological examinationPattern of impairment on cognitive tests; Laboratory studies; Structural imaging studies; Functional imaging studies; Differential diagnosis; Treatments; References; Chapter 5: Dementia with Lewy bodies (including Parkinson's disease dementia); Prevalence, prognosis, and definition; Criteria and diagnosis; Risk factors, pathology, and pathophysiology; Common signs, symptoms, and stages; Things to look for in the history; Things to look for on the physical and neurological examination; Pattern of impairment on cognitive tests , Laboratory studiesStructural imaging studies; Functional imaging studies; Differential diagnosis; Treatments; References; Chapter 6: Vascular dementia and vascular cognitive impairment; Prevalence, prognosis, and definition; Criteria; Risk factors, pathology, and pathophysiology; Common signs, symptoms, and stages; Things to look for in the history; Things to look for on the physical and neurological examination; Pattern of impairment on cognitive tests; Laboratory studies; Structural imaging studies; Functional imaging studies; Differential diagnosis; Treatments; References , Chapter 7: Frontotemporal dementia , English

Additional Edition: ISBN 1-4160-3597-4

Language: English

UID:

Format: 1 Online-Ressource (293 Seiten).

Edition: 2nd edition

ISBN: 978-0-323-31610-1

Additional Edition: Erscheint auch als Druck-Ausgabe ISBN 978-0-323-28661-9

Language: English

Keywords: Amnesie ; Alzheimerkrankheit ; Demenz ; Diagnostik

URL: Volltext

URL: Volltext

UID:

Format: 1 online resource (xiv, 629 pages) : , illustrations (some color)

ISBN: 9781444344080 , 1444344080 , 9781444351132 , 1444351133 , 6613274178 , 9786613274175

Content: "The reference is a broad-ranging review of Alzheimer's disease and other dementias from both basic and clinical neuroscience perspectives; it provides scientists and medical professionals with an extensive introduction and an up-to-date review of cutting-edge scientific advances. Brings the reader up-to-date with cutting-edge developments in this exciting and fast-paced field -- Summarizes the most recent developments in the fields of Alzheimer's disease and dementia -- Brings together articles from a prominent and international group of contributors -- Encompasses a unique range of topics, combining basic molecular perspectives and cognitive neurosciences."--Provided by publisher.

Note: Alzheimer's disease / by Alan M. Mandell and Robert C. Green -- Vascular dementia / by Angela L. Jefferson, Amanda M. Gentile, and Ravi Kahlon -- Dementia with Lewy bodies / by Tamara G. Fong and Daniel Press -- Frontotemporal dementia / by Adam L. Boxer -- Other causes of dementia / by Peter Morin -- Genetic risk factors for dementia / by Paul Hollingworth and Julie Williams -- The neuropathology of the dementing disorders / by Ann C McKee and Brandon E. Gavett -- Amyloid beta peptide and the amyloid cascade hypothesis / by Carmela R. Abraham -- Other mechanisms of neurodegeneration / by Marina Boziki, Vassilis Papaliagkas, and MagdaTsolaki -- Rational therapeutics in dementia / by Neil W. Kowall -- Memory systems in dementia / by Andrew E. Budson -- Language processing in dementia / by Jamie Reilly, Joshua Troche, and Murray Grossman -- Executive functioning in dementia / by Robert A. Stern, Stacy L. Andersen, and Brandon E. Gavett -- Emotion and behavior in Alzheimer's disease and other dementias / by Christopher I. Wright -- Visuospatial function in Alzheimer's disease and related disorders / by Alice Cronin-Golomb -- Sleep and circadian rhythms in dementia / by David G. Harper -- Glimpses of the living brain with Alzheimer's disease / by Ronald J. Killiany -- Functional MRI in Alzheimer's disease and other dementias / by Maija Pihlajamäki & Reisa A. Sperling -- Molecular neuroimaging of the dementias: from scientific insights to clinical applications / by Bradford C. Dickerson -- Using EEG and MEG to understand brain physiology in Alzheimer's disease and related dementias / by Brandon A. Ally.

Additional Edition: Print version: Handbook of Alzheimer's disease and other dementias. Chichester, West Sussex, UK: Wiley-Blackwell, 2011 ISBN 9781405168281

Language: English

Keywords: Electronic books. ; Handboeken (vorm) ; Elektronische boeken. ; Electronic books. ; Handboeken (vorm) ; Elektronische boeken. ; Electronic books. ; Handboeken (vorm) ; Elektronische boeken.

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781444344110

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781444344110

URL: https://onlinelibrary.wiley.com/doi/book/10.1002/9781444344110

UID:

ISBN: 9780197607749 , 9780197607756

Content: " Remember things better by understanding how your memory works. If memory is a simple thing, why does it so often go awry? Why is forgetting so common? How can you be certain about something you remember8212 and be wrong about it? Why is it so difficult to remember people's names? How can you study hard for an exam but not be able to recall the material on the test? In Why We Forget, Dr. Andrew Budson and Dr. Elizabeth Kensinger address these questions and more, using their years of experience to guide readers into better memory. Why We Forget and How to Remember Better shows you how to use these answers to improve your memory. In its pages you will learn: How memory's most important function isn't to help you remember details from your past. How memory is actually a collection of different abilities. How you create, store, and retrieve memories of your daily life. Ways to control what you remember and what you forget. Ways to distinguish between a true and false memory. Effective ways to study for an exam. How to remember people's names, all your passwords, 50 digits of Pi, and anything else you wish. How memory changes in normal aging, Alzheimer's disease, depression, anxiety, PTSD, ADHD, and other disorders-including COVID brain fog. How exercise, nutrition, alcohol, cannabis, sleep, mindfulness, and music affect your memory. Why We Forget and How to Remember Better uses the science of memory to empower you with the knowledge you need to remember better, whether you are a college student looking to ace your next exam, a business professional preparing a presentation, or a healthcare worker needing to memorize the 600+ muscles in the human body."

Content: Rezension(1): "〈a href=http://lj.libraryjournal.com/ target=blank〉〈img src=https://images.contentreserve.com/libraryjournal_logo.png alt=Library Journal border=0 /〉〈/a〉: December 1, 2022 Memory experts Budson ( Memory Loss, Alzheimer's Disease, and Dementia ) and Kensinger ( Emotional Memory Across the Adult Lifespan ) clearly explain how memory works and how it can be improved. False memories and the best ways to remember daily information, such as the name of a person one just met or where a person parked their car, are also discussed. The book further breaks memory down into three types: episodic, which triggers recall, such as how one celebrated their last birthday or where they were when a historical event occurred,procedural memory, which enables one to remember how to do something even if one has not done it in several years, such as ride a bicycle,and collective memory, which is when people remember something done during a lifetime or someone they met in the past. Examples of that include remembering a college roommate or a previous job. Data in this book is based upon hundreds of published scientific studies and insights from these esteemed specialists. VERDICT This book is an essential read for all those concerned with memory loss and should be a part of all collections in the behavioral and social sciences. --Claude UryCopyright 2022 Library Journal, LLC Used with permission. "

Language: English

URL: https://img1.od-cdn.com/ImageType-200/0116-1/{25B17C14-A6FF-4131-9F98-8D5D831F4A5A}IMG200.JPG

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URL: https://samples.overdrive.com/?crid=25b17c14-a6ff-4131-9f98-8d5d831f4a5a&.epub-sample.overdrive.com

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UID:

Format: xiv, 629p. : , ill.

Edition: Electronic reproduction. Ann Arbor, MI : ProQuest, 2015. Available via World Wide Web. Access may be limited to ProQuest affiliated libraries.

Series Statement: Wiley-Blackwell handbooks of behavioral neuroscience

Language: English

Keywords: Electronic books.

URL: Click to View

UID:

Format: 1 online resource (182 pages) : , color illustrations, photographs, graphs

ISBN: 0-323-54426-6 , 0-323-54425-8

Note: Front Cover -- Chronic Traumatic Encephalopathy -- Chronic Traumatic Encephalopathy -- Copyright -- Contributors -- Foreword -- Preface -- Acknowledgments -- Contents -- 1 - History of Concussion and Chronic Traumatic Encephalopathy -- INTRODUCTION -- HISTORICAL THEORIES OF CONCUSSION -- Theories of Concussion -- Definitions of Concussion -- Centripetal Theory of Concussion -- Loss of Consciousness -- Researchers of Concussions and Their Sequelae -- CURRENT UNDERSTANDING OF CONCUSSION -- Forces Needed to Produce Concussion -- Current Definition of Concussion -- CONCUSSION IN ATHLETES -- Grading the Severity of Concussions -- Return-to-Play Guidelines -- Toward a Definition of Concussion -- Mechanically Induced Concussion Symptoms -- Current Definitions of Concussion -- CHRONIC TRAUMATIC ENCEPHALOPATHY IN ATHLETES -- CTE in Boxers -- Early Recognition in Football Players -- The Boston University Team Working to Understand CTE -- CTE Has Been Found in Many Contact Sports -- Unforgotten: The Paul Pender Story -- THE FUTURE OF CONCUSSION AND CTEIN ATHLETES -- Important Questions to Be AnsweredAbout CTE -- Increasing Recognition of CTE -- DISCLOSURES -- REFERENCES -- FURTHER READING -- 2 - Pathology of Chronic Traumatic Encephalopathy -- INTRODUCTION -- CTE IS COMMON IN CONTACT SPORT ATHLETES -- PATHOLOGIC FEATURES OF CTE -- The Physics of Brain Injury Determines the Location of Pathology -- Consensus Criteria Established -- Consensus Criteria Independently Verified -- CTE Spreads Through the Brain Even After the Trauma Has Stopped -- Stages of CTE -- Young Individuals With CTE -- CTE in Football Players From Ages 40 to 82 -- CTE in Other Sports -- CRITICAL QUESTIONS IN CTE -- How Common Is CTE? How Many People Have It? -- How Can We Diagnose CTE During Life? -- Could Anybody Get CTE? Or Are There Genetic Susceptibility Factors?. , Are Young Brains More Susceptible to CTE? What About Women? -- How Does CTE Start in the Brain? -- Once CTE Is Started, How Does It Spread in the Brain Even in the Absence of Trauma? -- Does Trauma or CTE Provoke Other Neurodegenerations Like Alzheimer's and Parkinson's Diseases? -- What Are the Treatments for CTE? -- SUMMARY -- DISCLOSURES -- REFERENCES -- FURTHER READING -- 3 - Chronic Traumatic Encephalopathy: Clinical Presentation and Diagnostic Criteria -- INTRODUCTION -- CTE: WHAT WE NEED TO KNOW -- HISTORY AND ANTHROPOLOGY OF REPETITIVE HEAD IMPACTS -- LONG-TERM CONSEQUENCES OF REPETITIVE HEAD IMPACT EXPOSURE -- DIAGNOSIS OF CTE DURING LIFE: THE CRITICAL NEXT STEP -- Clinical Presentation of CTE: Retrospective Postmortem Data -- TRAUMATIC ENCEPHALOPATHY SYNDROME -- Case Example A -- Case Example B -- NEED FOR OBJECTIVE IN VIVO BIOMARKERS -- Diagnosing and Evaluating Traumatic Encephalopathy Using Clinical Tests -- Preliminary biomarker findings -- DIAGNOSE CTE RESEARCH PROJECT -- Diagnose CTE Research Project: Methods and Specific Aims -- CONCLUDING REMARKS -- REFERENCES -- 4 - Biomechanics of Head Trauma -- INTRODUCTION -- ACCELERATION-BASED BRAIN INJURY -- WAYNE STATE TOLERANCE CURVE -- BRAIN INJURY BIOMECHANICS -- CONCUSSIVE IMPACTS IN FOOTBALL -- CONCUSSIVE IMPACTS IN YOUNGER AGES -- TOWARD REDUCING CONCUSSIVE IMPACTS IN ATHLETES -- REFERENCES -- 5 - Mechanisms of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy: Acute and Chronic Effects of Blast Exposure -- INTRODUCTION -- DEFINITIONS -- CTE IN BLAST AND IMPACT INJURY -- BLAST NEUROTRAUMA MOUSE MODEL -- CHANGE IN HEAD ACCELERATION IS THE KEY -- Blast Exposure Triggers Microscopic CTE Pathology but Not Macroscopic Injury -- Changes in Brain Physiology -- Relating the Mouse Model to Human Disease -- CONCLUSIONS: PUTTING IT ALL TOGETHER -- DISCLOSURES -- REFERENCE. , 6 - Family Panel Discussion -- 7 - Genetics of Chronic Traumatic Encephalopathy -- INTRODUCTION -- WHY GENETICS MAY BE IMPORTANT FOR CTE -- METHODOLOGIES -- Choosing Controls -- Endophenotypes -- Repetitive Head Impacts Exposure Metrics -- Gene by Environment Interactions -- Epigenetics -- IMPLICATED GENES -- APOE -- MAPT Haplotype -- FUTURE DIRECTIONS -- ETHICS OF GENETIC TESTING -- CONCLUDING REMARKS -- REFERENCES -- FURTHER READING -- 8 - Comorbid Pathology in Chronic Traumatic Encephalopathy -- OVERVIEW OF COMORBID PATHOLOGIES SEEN IN CHRONIC TRAUMATIC ENCEPHALOPATHY -- COMPARISON OF PROGRESSION OF TAU PATHOLOGY IN CTE AND AD -- Β-AMYLOID IN CTE -- Age-Dependent Aβ Deposition -- Association of Aβ With CTE Stage and Tauopathy -- Association of Aβ With Dementia and Parkinsonism -- MODELING THE PATHOLOGY -- CONCLUSIONS -- REFERENCES -- 9 - Differential Diagnosis and Treatment of Chronic Traumatic Encephalopathy -- INTRODUCTION -- ALZHEIMER'S DISEASE IS THE MOST COMMON CAUSE OF DEMENTIA -- Diagnosis of Alzheimer's Disease Dementia -- Check vitamin D along with B12 and thyroid function -- Criteria for dementia and major neurocognitive disorder -- Criteria for Alzheimer's disease dementia -- Biomarkers and the continuum of Alzheimer's disease -- Biomarkers in clinical practice -- TREATMENT OF ALZHEIMER'S DISEASE DEMENTIA -- Cholinesterase Inhibitors -- Goals of Treatment -- Turning the Clock Back on Memory Loss -- Continue Cholinesterase Inhibitors as Long as There Is Function to Preserve -- Memantine for Moderate to Severe Dementia -- MILD COGNITIVE IMPAIRMENT -- Diagnostic Criteria for Mild Cognitive Impairment -- Prognosis of Mild Cognitive Impairment -- Treatment of Mild Cognitive Impairment -- DEMENTIA WITH LEWY BODIES -- VASCULAR DEMENTIA -- NORMAL-PRESSURE HYDROCEPHALUS -- FRONTOTEMPORAL DEMENTIA -- TREATING FRONTAL LOBE SYMPTOMS. , Pseudobulbar Affect -- Agitation -- CHRONIC TRAUMATIC ENCEPHALOPATHY -- Structural Imaging in CTE -- Functional Imaging in CTE -- Clinical Diagnosis of Probable CTE -- Pharmacological Treatment of Patients With Possible CTE -- Nonpharmacological Treatment of Patients With Possible CTE -- DISCLOSURES -- REFERENCES -- 10 - Fluid Biomarkers for Mild Traumatic Brain Injury and Chronic Traumatic Encephalopathy -- INTRODUCTION -- CEREBRAL SPINAL FLUID BIOMARKERS -- Acute TBI -- Boxers -- Window of Vulnerability Hypothesis -- Soccer Players -- BLOOD-BASED BIOMARKERS -- S-100B -- Single-Molecule Array in Serum and Plasma -- Plasma Tau in Ice Hockey Players -- Plasma Tau as a Marker for Concussion in Boxers -- Measuring Neurofilament Light in Serum and Plasma -- Serum Neurofilament Light and S-100B in Patients With Acute, Severe TBI -- Serum Neurofilament Light in Amateur Boxers -- BIOMARKERS FOR POSTCONCUSSIVE SYNDROME -- Hockey Players -- BIOMARKERS FOR REPETITIVE HEAD INJURY -- Plasma Total Tau in National Football League Players -- Exosomal Tau in National Football League Players -- Neurofilament Light in National Football League Players -- THE TIME COURSE OF CHANGE IN PLASMA BIOMARKERS IS KEY -- DISCLOSURES -- REFERENCES -- 11 - Toward Imaging Chronic Traumatic Encephalopathy -- OVERVIEW -- BACKGROUND -- IN VIVO BRAIN IMAGING FINDINGS IN FORMER NFL PLAYERS -- Cortical Atrophy and Cavum Septum Pellucidum -- Volumes of Hippocampus, Amygdala, Cingulate Gyrus, and Thalamus -- Basic Principles of Diffusion Tensor Imaging -- Repetitive Head Trauma and Possible Effects of Age at First Exposure to Trauma -- BRAIN IMAGING FINDINGS IN VIVO IN PROFESSIONAL SOCCER PLAYERS -- REPETITIVE HEAD IMPACTS IN UNIVERSITY HOCKEY PLAYERS -- ADVANCED IMAGING MEASURES FOR USE IN THE DIAGNOSE U01 GRANT -- Introduction -- PET Imaging Using β-Amyloid and Tau Ligands. , Free-Water Imaging -- Subject-Specific Analyses: Precision Medicine Approach -- Beyond Diffusion Tensor Imaging -- SUMMARY AND CONCLUSIONS -- DISCLOSURE -- REFERENCES -- 12 - From Chronic Traumatic Encephalopathy Biomarkers to Therapeutics: What We Need to Know to Design Clinical Trials -- INTRODUCTION -- TERMINOLOGY -- Endophenotypes -- Biomarkers -- Types of Studies -- MICROVASCULAR INJURY -- Cerebral Microcirculation and the Neurovascular Unit -- Diffuse Vascular Injury After TBI -- Response of Cerebral Microvasculature to TBI -- In Vivo Imaging of Cerebral Microvasculature in Response to TBI -- PHASE II STUDY: SILDENAFIL FOR CEREBROVASCULAR DYSFUNCTION IN CHRONIC TRAUMATIC BRAIN INJURY -- Mechanism of Sildenafil -- Design of the Phase II Study -- Participant Demographics -- Assessment of Vessel Reactivity With CO2 -- Assessment of Cerebral Blood Flow Using Arterial Spin Labeling and Cerebrovascular Reactivity Using Hypercapnia BOLD MRI -- Single-Dose Sildenafil in Patients With Chronic TBI and Healthy Controls -- FUNCTIONAL NEAR-INFRARED SPECTROSCOPY -- CONCLUSIONS -- REFERENCES -- 13 - Athlete Panel Discussion -- THE CONCUSSION LEGACY FOUNDATION -- INTRODUCTION OF THE PANEL -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W.

Language: English

UID:

Format: 1 online resource (182 pages) : , color illustrations, photographs, graphs

ISBN: 0-323-54426-6 , 0-323-54425-8

Note: Front Cover -- Chronic Traumatic Encephalopathy -- Chronic Traumatic Encephalopathy -- Copyright -- Contributors -- Foreword -- Preface -- Acknowledgments -- Contents -- 1 - History of Concussion and Chronic Traumatic Encephalopathy -- INTRODUCTION -- HISTORICAL THEORIES OF CONCUSSION -- Theories of Concussion -- Definitions of Concussion -- Centripetal Theory of Concussion -- Loss of Consciousness -- Researchers of Concussions and Their Sequelae -- CURRENT UNDERSTANDING OF CONCUSSION -- Forces Needed to Produce Concussion -- Current Definition of Concussion -- CONCUSSION IN ATHLETES -- Grading the Severity of Concussions -- Return-to-Play Guidelines -- Toward a Definition of Concussion -- Mechanically Induced Concussion Symptoms -- Current Definitions of Concussion -- CHRONIC TRAUMATIC ENCEPHALOPATHY IN ATHLETES -- CTE in Boxers -- Early Recognition in Football Players -- The Boston University Team Working to Understand CTE -- CTE Has Been Found in Many Contact Sports -- Unforgotten: The Paul Pender Story -- THE FUTURE OF CONCUSSION AND CTEIN ATHLETES -- Important Questions to Be AnsweredAbout CTE -- Increasing Recognition of CTE -- DISCLOSURES -- REFERENCES -- FURTHER READING -- 2 - Pathology of Chronic Traumatic Encephalopathy -- INTRODUCTION -- CTE IS COMMON IN CONTACT SPORT ATHLETES -- PATHOLOGIC FEATURES OF CTE -- The Physics of Brain Injury Determines the Location of Pathology -- Consensus Criteria Established -- Consensus Criteria Independently Verified -- CTE Spreads Through the Brain Even After the Trauma Has Stopped -- Stages of CTE -- Young Individuals With CTE -- CTE in Football Players From Ages 40 to 82 -- CTE in Other Sports -- CRITICAL QUESTIONS IN CTE -- How Common Is CTE? How Many People Have It? -- How Can We Diagnose CTE During Life? -- Could Anybody Get CTE? Or Are There Genetic Susceptibility Factors?. , Are Young Brains More Susceptible to CTE? What About Women? -- How Does CTE Start in the Brain? -- Once CTE Is Started, How Does It Spread in the Brain Even in the Absence of Trauma? -- Does Trauma or CTE Provoke Other Neurodegenerations Like Alzheimer's and Parkinson's Diseases? -- What Are the Treatments for CTE? -- SUMMARY -- DISCLOSURES -- REFERENCES -- FURTHER READING -- 3 - Chronic Traumatic Encephalopathy: Clinical Presentation and Diagnostic Criteria -- INTRODUCTION -- CTE: WHAT WE NEED TO KNOW -- HISTORY AND ANTHROPOLOGY OF REPETITIVE HEAD IMPACTS -- LONG-TERM CONSEQUENCES OF REPETITIVE HEAD IMPACT EXPOSURE -- DIAGNOSIS OF CTE DURING LIFE: THE CRITICAL NEXT STEP -- Clinical Presentation of CTE: Retrospective Postmortem Data -- TRAUMATIC ENCEPHALOPATHY SYNDROME -- Case Example A -- Case Example B -- NEED FOR OBJECTIVE IN VIVO BIOMARKERS -- Diagnosing and Evaluating Traumatic Encephalopathy Using Clinical Tests -- Preliminary biomarker findings -- DIAGNOSE CTE RESEARCH PROJECT -- Diagnose CTE Research Project: Methods and Specific Aims -- CONCLUDING REMARKS -- REFERENCES -- 4 - Biomechanics of Head Trauma -- INTRODUCTION -- ACCELERATION-BASED BRAIN INJURY -- WAYNE STATE TOLERANCE CURVE -- BRAIN INJURY BIOMECHANICS -- CONCUSSIVE IMPACTS IN FOOTBALL -- CONCUSSIVE IMPACTS IN YOUNGER AGES -- TOWARD REDUCING CONCUSSIVE IMPACTS IN ATHLETES -- REFERENCES -- 5 - Mechanisms of Concussion, Traumatic Brain Injury, and Chronic Traumatic Encephalopathy: Acute and Chronic Effects of Blast Exposure -- INTRODUCTION -- DEFINITIONS -- CTE IN BLAST AND IMPACT INJURY -- BLAST NEUROTRAUMA MOUSE MODEL -- CHANGE IN HEAD ACCELERATION IS THE KEY -- Blast Exposure Triggers Microscopic CTE Pathology but Not Macroscopic Injury -- Changes in Brain Physiology -- Relating the Mouse Model to Human Disease -- CONCLUSIONS: PUTTING IT ALL TOGETHER -- DISCLOSURES -- REFERENCE. , 6 - Family Panel Discussion -- 7 - Genetics of Chronic Traumatic Encephalopathy -- INTRODUCTION -- WHY GENETICS MAY BE IMPORTANT FOR CTE -- METHODOLOGIES -- Choosing Controls -- Endophenotypes -- Repetitive Head Impacts Exposure Metrics -- Gene by Environment Interactions -- Epigenetics -- IMPLICATED GENES -- APOE -- MAPT Haplotype -- FUTURE DIRECTIONS -- ETHICS OF GENETIC TESTING -- CONCLUDING REMARKS -- REFERENCES -- FURTHER READING -- 8 - Comorbid Pathology in Chronic Traumatic Encephalopathy -- OVERVIEW OF COMORBID PATHOLOGIES SEEN IN CHRONIC TRAUMATIC ENCEPHALOPATHY -- COMPARISON OF PROGRESSION OF TAU PATHOLOGY IN CTE AND AD -- Β-AMYLOID IN CTE -- Age-Dependent Aβ Deposition -- Association of Aβ With CTE Stage and Tauopathy -- Association of Aβ With Dementia and Parkinsonism -- MODELING THE PATHOLOGY -- CONCLUSIONS -- REFERENCES -- 9 - Differential Diagnosis and Treatment of Chronic Traumatic Encephalopathy -- INTRODUCTION -- ALZHEIMER'S DISEASE IS THE MOST COMMON CAUSE OF DEMENTIA -- Diagnosis of Alzheimer's Disease Dementia -- Check vitamin D along with B12 and thyroid function -- Criteria for dementia and major neurocognitive disorder -- Criteria for Alzheimer's disease dementia -- Biomarkers and the continuum of Alzheimer's disease -- Biomarkers in clinical practice -- TREATMENT OF ALZHEIMER'S DISEASE DEMENTIA -- Cholinesterase Inhibitors -- Goals of Treatment -- Turning the Clock Back on Memory Loss -- Continue Cholinesterase Inhibitors as Long as There Is Function to Preserve -- Memantine for Moderate to Severe Dementia -- MILD COGNITIVE IMPAIRMENT -- Diagnostic Criteria for Mild Cognitive Impairment -- Prognosis of Mild Cognitive Impairment -- Treatment of Mild Cognitive Impairment -- DEMENTIA WITH LEWY BODIES -- VASCULAR DEMENTIA -- NORMAL-PRESSURE HYDROCEPHALUS -- FRONTOTEMPORAL DEMENTIA -- TREATING FRONTAL LOBE SYMPTOMS. , Pseudobulbar Affect -- Agitation -- CHRONIC TRAUMATIC ENCEPHALOPATHY -- Structural Imaging in CTE -- Functional Imaging in CTE -- Clinical Diagnosis of Probable CTE -- Pharmacological Treatment of Patients With Possible CTE -- Nonpharmacological Treatment of Patients With Possible CTE -- DISCLOSURES -- REFERENCES -- 10 - Fluid Biomarkers for Mild Traumatic Brain Injury and Chronic Traumatic Encephalopathy -- INTRODUCTION -- CEREBRAL SPINAL FLUID BIOMARKERS -- Acute TBI -- Boxers -- Window of Vulnerability Hypothesis -- Soccer Players -- BLOOD-BASED BIOMARKERS -- S-100B -- Single-Molecule Array in Serum and Plasma -- Plasma Tau in Ice Hockey Players -- Plasma Tau as a Marker for Concussion in Boxers -- Measuring Neurofilament Light in Serum and Plasma -- Serum Neurofilament Light and S-100B in Patients With Acute, Severe TBI -- Serum Neurofilament Light in Amateur Boxers -- BIOMARKERS FOR POSTCONCUSSIVE SYNDROME -- Hockey Players -- BIOMARKERS FOR REPETITIVE HEAD INJURY -- Plasma Total Tau in National Football League Players -- Exosomal Tau in National Football League Players -- Neurofilament Light in National Football League Players -- THE TIME COURSE OF CHANGE IN PLASMA BIOMARKERS IS KEY -- DISCLOSURES -- REFERENCES -- 11 - Toward Imaging Chronic Traumatic Encephalopathy -- OVERVIEW -- BACKGROUND -- IN VIVO BRAIN IMAGING FINDINGS IN FORMER NFL PLAYERS -- Cortical Atrophy and Cavum Septum Pellucidum -- Volumes of Hippocampus, Amygdala, Cingulate Gyrus, and Thalamus -- Basic Principles of Diffusion Tensor Imaging -- Repetitive Head Trauma and Possible Effects of Age at First Exposure to Trauma -- BRAIN IMAGING FINDINGS IN VIVO IN PROFESSIONAL SOCCER PLAYERS -- REPETITIVE HEAD IMPACTS IN UNIVERSITY HOCKEY PLAYERS -- ADVANCED IMAGING MEASURES FOR USE IN THE DIAGNOSE U01 GRANT -- Introduction -- PET Imaging Using β-Amyloid and Tau Ligands. , Free-Water Imaging -- Subject-Specific Analyses: Precision Medicine Approach -- Beyond Diffusion Tensor Imaging -- SUMMARY AND CONCLUSIONS -- DISCLOSURE -- REFERENCES -- 12 - From Chronic Traumatic Encephalopathy Biomarkers to Therapeutics: What We Need to Know to Design Clinical Trials -- INTRODUCTION -- TERMINOLOGY -- Endophenotypes -- Biomarkers -- Types of Studies -- MICROVASCULAR INJURY -- Cerebral Microcirculation and the Neurovascular Unit -- Diffuse Vascular Injury After TBI -- Response of Cerebral Microvasculature to TBI -- In Vivo Imaging of Cerebral Microvasculature in Response to TBI -- PHASE II STUDY: SILDENAFIL FOR CEREBROVASCULAR DYSFUNCTION IN CHRONIC TRAUMATIC BRAIN INJURY -- Mechanism of Sildenafil -- Design of the Phase II Study -- Participant Demographics -- Assessment of Vessel Reactivity With CO2 -- Assessment of Cerebral Blood Flow Using Arterial Spin Labeling and Cerebrovascular Reactivity Using Hypercapnia BOLD MRI -- Single-Dose Sildenafil in Patients With Chronic TBI and Healthy Controls -- FUNCTIONAL NEAR-INFRARED SPECTROSCOPY -- CONCLUSIONS -- REFERENCES -- 13 - Athlete Panel Discussion -- THE CONCUSSION LEGACY FOUNDATION -- INTRODUCTION OF THE PANEL -- Index -- A -- B -- C -- D -- E -- F -- G -- H -- I -- M -- N -- O -- P -- R -- S -- T -- U -- V -- W.

Language: English

UID:

Format: XIV, 629 S.

ISBN: 978-1-405-16828-1

Series Statement: Wiley-Blackwell handbooks of behavioral neuroscience

Note: Includes bibliographical references and index

Language: English

Subjects: Medicine

URL: http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=024549820&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA