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  • 1
    Online Resource
    Online Resource
    Natural Killer Cells in Tissue Compartments (2020)
    [Erscheinungsort nicht ermittelbar] : Frontiers Media SA
    Details
    UID:
    gbv_1794588221
    Format: 1 Online-Ressource (256 p.)
    ISBN: 9782889636129
    Content: n the last years, our knowledge of human NK cell biology has increased significantly. Several stimulating studies have provided the basis for understanding how NK cells can be “educated” to acquire immunological competence following maturation, or to adapt their function to the environmental changes of “self”. New information has been acquired on their lifespan and on the persistence of memory-like NK cell subsets in response to certain viral infections. In addition, the identification and characterization of new markers and the development of more effective analytic approaches have led to the definition of various phenotypically and/or functionally-defined cell subsets. These advances have, in turn, enabled us to study NK cells beyond the peripheral blood, in different tissue compartments including the bone marrow, liver, lungs, skin, intestine and uterus. Recent data indicates that at least part of the tissue NK cell compartment consists of resident cells (which rarely recirculate) characterized by tissue-specific phenotypes and, in some cases, endowed with specialized functions related to the distinct organs in which they reside. These findings stimulate further questions (i) on the origins of these putative tissue-specific NK cell subsets; (ii) on their functional interplay with the local microenvironment; (iii) on their immunological competence and memory capacity and (iv) on their possible specific functional role in healthy and diseased tissues. In this context, the assessment of phenotype, function, maturation, education, differentiation and reprogramming of effector functions in tissue NK cells represents a new stimulating field of investigation that would help to get a more comprehensive picture of NK cell biology. In this Research Topic, we collect articles that highlight the recent advances in our understanding of tissue NK cells and that provide insight into opening new viewpoints on the role of NK cells in both health and disease
    Note: English
    Language: English
    URL: kostenfrei
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Stabi Berlin
    UB Potsdam
  • 2
    Online Resource
    Online Resource
    Cytokines in the genesis and treatment of cancer / (2007)
    Totowa, NJ :Humana Press,
    Details
    UID:
    almahu_BV023016022
    Format: 1 Online-Ressource.
    ISBN: 1-59745-455-9 , 978-0-89603-820-2 , 978-1-59745-455-1
    Series Statement: Cancer drug discovery and development
    Language: English
    Subjects: Medicine
    RVK:
    XH 3200
    Keywords: Cytokine ; Krebs ; Aufsatzsammlung
    DOI: 10.1007/978-1-59745-455-1
    URL: Volltext
    URL: http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016220180&sequence=000006&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Online Access
    Open Access Request
    HU Berlin
    Charité
  • 3
    Online Resource
    Online Resource
    Natural Killer Cells in Tissue Compartments (2020)
    Frontiers Media SA
    Details
    UID:
    edoccha_9960407396602883
    Format: 1 electronic resource (256 p.)
    Content: n the last years, our knowledge of human NK cell biology has increased significantly. Several stimulating studies have provided the basis for understanding how NK cells can be “educated” to acquire immunological competence following maturation, or to adapt their function to the environmental changes of “self”. New information has been acquired on their lifespan and on the persistence of memory-like NK cell subsets in response to certain viral infections. In addition, the identification and characterization of new markers and the development of more effective analytic approaches have led to the definition of various phenotypically and/or functionally-defined cell subsets. These advances have, in turn, enabled us to study NK cells beyond the peripheral blood, in different tissue compartments including the bone marrow, liver, lungs, skin, intestine and uterus. Recent data indicates that at least part of the tissue NK cell compartment consists of resident cells (which rarely recirculate) characterized by tissue-specific phenotypes and, in some cases, endowed with specialized functions related to the distinct organs in which they reside. These findings stimulate further questions (i) on the origins of these putative tissue-specific NK cell subsets; (ii) on their functional interplay with the local microenvironment; (iii) on their immunological competence and memory capacity and (iv) on their possible specific functional role in healthy and diseased tissues. In this context, the assessment of phenotype, function, maturation, education, differentiation and reprogramming of effector functions in tissue NK cells represents a new stimulating field of investigation that would help to get a more comprehensive picture of NK cell biology. In this Research Topic, we collect articles that highlight the recent advances in our understanding of tissue NK cells and that provide insight into opening new viewpoints on the role of NK cells in both health and disease.
    Note: English
    Additional Edition: ISBN 2-88963-612-7
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    Charité
  • 4
    Online Resource
    Online Resource
    Natural Killer Cells in Tissue Compartments (2020)
    Frontiers Media SA
    Details
    UID:
    almahu_9949281335902882
    Format: 1 electronic resource (256 p.)
    Content: n the last years, our knowledge of human NK cell biology has increased significantly. Several stimulating studies have provided the basis for understanding how NK cells can be “educated” to acquire immunological competence following maturation, or to adapt their function to the environmental changes of “self”. New information has been acquired on their lifespan and on the persistence of memory-like NK cell subsets in response to certain viral infections. In addition, the identification and characterization of new markers and the development of more effective analytic approaches have led to the definition of various phenotypically and/or functionally-defined cell subsets. These advances have, in turn, enabled us to study NK cells beyond the peripheral blood, in different tissue compartments including the bone marrow, liver, lungs, skin, intestine and uterus. Recent data indicates that at least part of the tissue NK cell compartment consists of resident cells (which rarely recirculate) characterized by tissue-specific phenotypes and, in some cases, endowed with specialized functions related to the distinct organs in which they reside. These findings stimulate further questions (i) on the origins of these putative tissue-specific NK cell subsets; (ii) on their functional interplay with the local microenvironment; (iii) on their immunological competence and memory capacity and (iv) on their possible specific functional role in healthy and diseased tissues. In this context, the assessment of phenotype, function, maturation, education, differentiation and reprogramming of effector functions in tissue NK cells represents a new stimulating field of investigation that would help to get a more comprehensive picture of NK cell biology. In this Research Topic, we collect articles that highlight the recent advances in our understanding of tissue NK cells and that provide insight into opening new viewpoints on the role of NK cells in both health and disease.
    Note: English
    Additional Edition: ISBN 2-88963-612-7
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    HU Berlin
  • 5
    Online Resource
    Online Resource
    Natural Killer Cells in Tissue Compartments (2020)
    Frontiers Media SA
    Details
    UID:
    edocfu_9960407396602883
    Format: 1 electronic resource (256 p.)
    Content: n the last years, our knowledge of human NK cell biology has increased significantly. Several stimulating studies have provided the basis for understanding how NK cells can be “educated” to acquire immunological competence following maturation, or to adapt their function to the environmental changes of “self”. New information has been acquired on their lifespan and on the persistence of memory-like NK cell subsets in response to certain viral infections. In addition, the identification and characterization of new markers and the development of more effective analytic approaches have led to the definition of various phenotypically and/or functionally-defined cell subsets. These advances have, in turn, enabled us to study NK cells beyond the peripheral blood, in different tissue compartments including the bone marrow, liver, lungs, skin, intestine and uterus. Recent data indicates that at least part of the tissue NK cell compartment consists of resident cells (which rarely recirculate) characterized by tissue-specific phenotypes and, in some cases, endowed with specialized functions related to the distinct organs in which they reside. These findings stimulate further questions (i) on the origins of these putative tissue-specific NK cell subsets; (ii) on their functional interplay with the local microenvironment; (iii) on their immunological competence and memory capacity and (iv) on their possible specific functional role in healthy and diseased tissues. In this context, the assessment of phenotype, function, maturation, education, differentiation and reprogramming of effector functions in tissue NK cells represents a new stimulating field of investigation that would help to get a more comprehensive picture of NK cell biology. In this Research Topic, we collect articles that highlight the recent advances in our understanding of tissue NK cells and that provide insight into opening new viewpoints on the role of NK cells in both health and disease.
    Note: English
    Additional Edition: ISBN 2-88963-612-7
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Online Resource
    FU Berlin
  • 6
    Online Resource
    Online Resource
    Cytokines in the Genesis and Treatment of Cancer (2007)
    Totowa, NJ : Humana Press Inc
    Details
    UID:
    gbv_550119205
    Format: Online-Ressource , v.: digital
    Edition: Online-Ausg. Springer eBook Collection. Biomedical and Life Sciences Electronic reproduction; Available via World Wide Web
    ISBN: 9781597454551
    Series Statement: Cancer Drug Discovery and Development
    Content: Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. The book brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer.
    Content: Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. Divided into four sections, the volume s first three parts focus on cytokines in the genesis of cancer. The final section describes the notable progress - both in animal models and humans - in demonstrating the use of cytokine or anticytokine therapies for the prevention and treatment of cancer. Cytokines in the Genesis and Treatment of Cancer brings together an impressive array of internationally distinguished investigators who are devoted to the study of cytokines and cancer. Together, they produce an insightful, comprehensive discussion of cytokines and cancer that will serve as the perfect reference for all those working in the field.
    Note: Description based upon print version of record , Foreword; Preface; CONTENTS; Contributors; I INFECTIOUS AGENTS, CYTOKINES, AND CANCER; 1 Helicobacter pylori and Cytokines in the Genesis of Gastric Cancer; 2 HTLV-1, Cytokines, and Cancer; 3 Herpesviruses, Cytokines, and Cancer; II CYTOKINES AND CARCINOGENESIS; 4 Tumor Necrosis Factor and Cancer; 5 Transforming Growth Factor-B and Cancer; 6 Interleukin-1 Family of Cytokines and Cancer; 7 Interleukin-4/13 and Cancer; 8 Interleukin-6 and Castleman's Disease; 9 Interleukin-10 (IL-10); 10 Cytokines in Multiple Myeloma; 11 In Vivo Murine Cytokine Models and the Genesis of Cancer , 12 Experimental Models of Cytokines and Cancer PreventionIII CYTOKINES AND TUMOR STROMA/METASTASIS; 13 Cytokines in the Tumor Stroma; 14 Cytokines and Tumor Angionesis; 15 Chemokine and Receptor Expression in Tumor Progression; 16 The Biology of Cancer Cachexia and the Role of TNF-a; IV CYTOKINES IN THE TREATMENT OF CANCER; 17 Interleukin-2 and Cancer Therapy; 18 Interleukin-12 and Cancer Therapy; 19 The Type I Interferon System With Emphasis on Its Role in Malignancies; 20 Combination Cytokine Therapy; 21 Novel Strategies for Cytokine Administrative Via Targetting , 22 Cytokines and Cancer Vaccines23 Anticytokine Treatment; 24 Cytokine in the Supportive Care of Cancer; Index , Electronic reproduction; Available via World Wide Web
    Additional Edition: ISBN 9780896038202
    Language: English
    Subjects: Medicine
    RVK:
    XH 3200
    Keywords: Krebs ; Cytokine ; Aufsatzsammlung
    DOI: 10.1007/978-1-59745-455-1
    URL: Volltext  (lizenzpflichtig)
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Online Access
    Open Access Request
    UB Potsdam
  • 7
    Online Resource
    Online Resource
    Natural killer cells : development, diversity and applications to human disease (2009)
    London, England :Henry Stewart Talks,
    Details
    UID:
    edoccha_9961427360202883
    Format: 1 online resource (1 streaming video file (48 min., 02 sec.)) , 004802
    Note: Retrieved April 12, 2024, from https://hstalks.com/bs/1455/. , Introduction -- Talk outline -- Known facts about NK cell development (1993) -- IL-2 and IL-15 receptors -- IL-15 induces human NK cell differentiation -- Factors responsible for NK cells development -- KL/FL ligands and NK cells development (1) -- KL/FL ligands and NK cells development (2) -- SCF, IL-2 and IL-15 in NK cell development -- Human natural killer cell development -- Which CD34 subset develops into a NK cell? -- CD34 receptor expression -- CD34 in peripheral blood and lymph nodes -- NK precursor selectively enriched in lymph nodes -- Site of NK cell development -- NK cells in lymph nodes are CD56 bright cells -- Putative stages of human NK cell differentiation -- NK cell development in human lymphopoiesis -- IL-15 and human NK cell survival -- Adoptive transfer of NK cells -- IL-15 is required for NK cell survival in vivo -- IL-15 and NK cell development and survival -- The IL-15 transgene -- NK cell expansion in IL-15tg mice -- IL-15tg mice clinical signs and findings -- Acute T-NK lymphoblastic leukemia -- NK cell maturation -- NK cell subsets -- The immunoregulatory role of NK cell subsets -- Where does the INF-gamma signal come from? -- Macrophage and NK co-culture: LPS activation (1) -- NK cell-derived IFN-gamma -- Macrophage and NK co-culture: LPS activation (2) -- Bright cells are the primary source of IFN-gamma -- IFN-gamma production in bright and dim cells -- CD56 bright NK cells in the immune response -- Innate immunoregulator, CD56 bright -- Innate cytotoxic effector, CD56 dim -- How do inhibitory NKR work? (1) -- How does KIR work? -- How do Inhibitory NKR work? (2) -- The inhibitory receptors bind to specific epitopes -- Common epitopes that bind to these receptors -- Haplo-mismatch bone marrow transplant (BMT) -- Haplo-mismatch BMT that results in lysis -- Haplo-mismatch BMT that results in no lysis -- Haplo-mismatch BMT - no lysis outcome -- Summary of haplo-mismatch BMT -- KIR mismatch/ no mismatch -- Conclusions -- Summary -- Acknowledgments.
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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    Online Resource
    Charité
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