UID:
edoccha_9960073838202883
Format:
1 online resource (126 p.)
ISBN:
0-323-29652-1
Series Statement:
Micro and Nano Technologies Series
Content:
Self-assembled nanostructures based on peptides and proteins have been investigated and presented as biomaterials with an impressive potential for a broad range of applications such as microfabrication, biosensing platforms, drug delivery systems, bioelectronics and tissue reparation. Through self-assembly peptides can give rise to a range of well-defined nanostructures such as nanotubes, nanofibers, nanoparticles, nanotapes, gels and nanorods. However, there are challenges when trying to integrate these biological nanostructures in the development of sensing devices or drug-delivery systems
Note:
Description based upon print version of record.
,
Cover; Title Page; Copyright Page; Table of contents; Contributors; Preface; Chapter 1 - Self-Assembled Biological Nanofibers for Biosensor Applications; 1.1 - Introduction; 1.2 - Types of self-assembled biological nanofibers; 1.2.1 - Natural Protein Nanofibers; 1.2.2 - Amyloid Fibrils; 1.2.3 - Peptide Nanotubes and Nanowires; 1.3 - Practical laboratory considerations; 1.3.1 - Temperature Stability; 1.3.2 - Solvents and Solubility; 1.4 - Functionalization approaches; 1.4.1 - Chemical Approaches; 1.4.2 - Physical Approaches; 1.5 - Common challenges in biosensor platforms
,
1.5.1 - Manipulation1.5.1.1 - AFM-Based Techniques; 1.5.1.2 - Dielectrophoresis; 1.5.1.3 - Soft-Lithography; 1.5.1.4 - Chemical Immobilization; 1.5.2 - Conductive Properties in Bio-FETs; 1.5.3 - Charge-Blocking Behavior in Electrochemical Platforms; 1.6 - Conclusions; References; Chapter 2 - Fabrication of Nanostructures Using Self-Assembled Peptides as Templates: The Diphenylalanine Case; 2.1 - Introduction; 2.2 - Diphenylalanine peptide; 2.2.1 - Synthesis of Nanostructures Using Diphenylalanine; 2.2.2 - Stability of Diphenylalanine Nanostructures
,
2.2.3 - Manipulation of Diphenylalanine Peptide Nanostructures2.3 - Fabrication of new nanostructures using diphenylalanine nanostructures as a template; 2.3.1 - Fabrication of Metallic Nanowires and Coaxial Cables; 2.3.2 - Fabrication of Polymer Nanochannels; 2.3.3 - Fabrication of Silicon and Conducting Polymer Nanowires; 2.4 - Conclusions; References; Chapter 3 - Self-Assembled Peptide Nanostructures for the Fabrication of Cell Scaffolds; 3.1 - Introduction; 3.2 - Classes of self-assembled peptide scaffolds; 3.3 - Natural self-assembling peptide systems
,
3.3.1 - α-Helices/Coiled Coils 3.3.2 - β-Sheets; 3.3.3 - β-Hairpins; 3.4 - Semisynthetic self-assembling peptide systems; 3.4.1 - Peptide Amphiphiles; 3.4.2 - Lipid-Like Peptides; 3.4.3 - Aromatically Capped Peptide Derivatives; 3.5 - Fabrication and control of mechanical properties of peptide scaffolds; 3.5.1 - pH; 3.5.2 - Ionic Strength; 3.5.3 - Temperature; 3.5.4 - Biocatalytic Reactions; 3.5.5 - Photopolymerization; 3.6 - The in vitro and in vivo applications of self-assembly peptide scaffolds; 3.7 - Biofunctionalization of peptide hydrogels
,
3.7.1 - Peptide Epitopes Presented by the SAPs3.7.2 - Incorporating Macromolecules to the Scaffold; 3.8 - SAP scaffolds as a support for 3D cell culture; 3.8.1 - Alpha Helical; 3.8.2 - β-Sheets; 3.8.3 - β-Turns; 3.8.4 - Unnatural Amino Acids ; 3.8.5 - Short Peptide Derivatives; 3.9 - Utilizing self-assembly peptide scaffold as cell therapy in vivo; 3.9.1 - Myocardium; 3.9.2 - Bone Regeneration; 3.9.3 - Cartilage Repair; 3.9.4 - Angiogenesis; 3.9.5 - Neural Regeneration; 3.10 - Future perspectives; References
,
Chapter 4 - Self-Assembled Peptide Nanostructures for Regenerative Medicine and Biology
,
English
Additional Edition:
ISBN 0-323-29642-4
Additional Edition:
ISBN 1-322-11433-1
Language:
English
Bookmarklink
