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  • 1
    Online Resource
    Online Resource
    San Diego, California :Academic Press,
    UID:
    almahu_9948025864602882
    Format: 1 online resource (543 p.)
    ISBN: 0-12-407884-2
    Content: Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and d
    Note: Description based upon print version of record. , Front Cover; Cancer Theranostics; Copyright Page; Contents; Preface; Acknowledgments; About the Editors; List of Contributors; I: In Vitro Diagnostics; 1 Cancer Theranostics: An Introduction; Cancer Theranostics: A Definition; Theranostic Cancer Biomarkers; Molecular Imaging in Cancer Theranostics; Imaging-Guided Cancer Therapy; Theranostic Platforms; Challenges and Future Perspectives; References; 2 Genomics-Based Cancer Theranostics; Introduction; Next Generation Sequencing Technology for Genomics-Based Cancer Theranostics; NGS Technology; Available Platforms , Technologies for Oligonucleotide ReplicationSequencing Chemistries and Signal Detection Technologies; Bioinformatics for NGS; What's in an NGS Analysis Pipeline?; Common Errors/False Positives; Cancer-Specific Challenges; Sequencing Applications Focusing on Cancer Theranostics; Identification of Somatic Mutations in Cancers; Familial Genetic Testing; Cancer Cell Lineage Reconstruction via Single-Cell Genomics; Genomics Landscapes in Common Forms of Human Cancers; Overall Picture of Somatic Mutations in Cancer; Characterizing Driver versus Passenger Mutations and Genes; Genetic Heterogeneity , Functions of Key Signaling Pathways in CancerPathways Related to Differentiation; Pathways Related to Cell Growth and Proliferation; Pathways Related to Cell Survival; Pathways Related to Genome Maintenance and Apoptosis; Integration of Genomic Screening for Cancer Theranostics; Case 1:Patterns of Basal Signaling Heterogeneity are Related to Drug Sensitivity; Summary of Reported Work; Presented Opportunities; Case 2:Systematic Approach Helps the Design of Combined Therapy; Summary of Reported Work; Presented Opportunities , Case 3:HCS for Morphological Complexity Identifies Regulators of Switch-Like Transitions between Discrete Cell ShapesSummary of Reported Work; Presented Opportunities; Acknowledgments; Glossary; Abbreviations; References; 3 Proteomics-Based Theranostics; Introduction; Mass Spectrometry Techniques Used for Proteomics Biomarker Discovery; Dynamical Range of Proteins; Blood "Peptidome"; Other Biological Factors; Bioinformatics Analysis Pipeline for Proteomics Biomarker Discovery; Baseline Removal; Denoising/Smoothing; Discrete Wavelet Transform (DWT); Matched Filtration , Savitzky-Golay and Average MovingNormalization; Dividing by a Constant Value; Regression; Quantile; Peak Detection/Identification; Peak Alignment; Biomarker Candidate Identifications; Protein/Peptide Identification; Traditional Biomarker Discovery Methods; Challenges in Proteomics Biomarker Discovery; Existing Single Biomarkers; Knowledge-Integrated Network Biomarker Discovery; Differential Expressions for the Proteins in PCRN; Construction of PCRN; MS-Based Biomarker Discovery; Network Biomarker Identification on PCRN; Clinical Validation of Proteomics Biomarkers; Glossary; Abbreviations , References , English
    Additional Edition: ISBN 0-12-407722-6
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Online Resource
    Online Resource
    Hoboken, N.J. :Wiley,
    UID:
    almafu_9959327083802883
    Format: 1 online resource (xviii, 823 pages) : , illustrations
    ISBN: 9780470767047 , 0470767049 , 9780470767030 , 0470767030 , 1283282526 , 9781283282529
    Content: "Nanoplathform-Based Molecular Imaging provides rationale for using nanoparticle-based probes for molecular imaging, then discusses general strategies for this underutilized, yet promising, technology. It addresses general strategies of particle synthesis and surface chemistry, applications in computed tomography optical imaging, magnetic resonance imaging, ultrasound, multimodality imaging, theranostics, and finally, the clinical perspectives of nanoimaging. This comprehensive volume summarizes the opinions of those in the forefront of research and describes the latest developments by emphasizing fundamentals and initiating hands-on application"--Provided by publisher.
    Note: Frontmatter -- Basics of Molecular Imaging and Nanobiotechnology. Basic Principles of Molecular Imaging / Sven H Hausner -- Synthesis of Nanomaterials as a Platform for Molecular Imaging / Jinhao Gao, Jin Xie, Bing Xu, Xiaoyuan Chen -- Nanoparticle Surface Modification and Bioconjugation / Jin Xie, Jinhao Gao, Mark Michalski, Xiaoyuan Chen -- Biodistribution and Pharmacokinetics of Nanoprobes / Nagesh Kolishetti, Frank Alexis, Eric M Pridgen, Omid C Farokhzad -- Nanoparticles for Single Modality Molecular Imaging. Computed Tomography as a Tool for Anatomical and Molecular Imaging / Pingyu Liu, Hu Zhou, Lei Xing -- Carbon Nanotube X-Ray for Dynamic Micro-CT Imaging of Small Animal Models / Otto Zhou, Guohua Cao, Yueh Z Lee, Jianping Lu -- Quantum Dots for Molecular Imaging / Yun Xing -- Biopolymer, Dendrimer, and Liposome Nanoplatforms for Optical Molecular Imaging / David Pham, Ling Zhang, Bo Chen, Ella Fung Jones -- Nanoplatforms for Raman Molecular Imaging in Biological Systems / Zhuang Liu -- Single-Walled Carbon Nanotube Near-Infrared Fluorescent Sensors for Biological Systems / Jingqing Zhang, Michael S Strano -- Microparticle- and Nanoparticle-Based Contrast-Enhanced Ultrasound Imaging / Nirupama Deshpande, Jürgen K Willmann -- Ultrasound-Based Molecular Imaging Using Nanoagents / Srivalleesha Mallidi, Mohammad Mehrmohammadi, Kimberly Homan, Bo Wang, Min Qu, Timothy Larson, Konstantin Sokolov, Stanislav Emelianov -- MRI Contrast Agents Based on Inorganic Nanoparticles / Hyon Bin Na, Taeghwan Hyeon -- Cellular Magnetic Labeling with Iron Oxide Nanoparticles / Šbastien Boutry, Sophie Laurent, Luce Vander Elst, Robert N Muller -- Nanoparticles Containing Rare Earth Ions: A Tunable Tool for MRI / C Rivïre, S Roux, R Bazzi, J-L Bridot, C Billotey, P Perriat, O Tillement -- Microfabricated Multispectral MRI Contrast Agents / Gary Zabow, Alan Koretsky -- Radiolabeled Nanoplatforms: Imaging Hot Bullets Hitting their Target / Raffaella Rossin -- Nanoparticle Platforms as Multimodality Imaging and Therapy Agents. Lipoprotein-Based Nanoplatforms for Cancer Molecular Imaging / Ian R Corbin, Kenneth Ng, Gang Zheng -- Protein Cages as Multimode Imaging Agents / Masaki Uchida, Lars Liepold, Mark Young, Trevor Douglas -- Biomedical Applications of Single-Walled Carbon Nanotubes / Weibo Cai, Ting Gao, Hao Hong -- Multifunctional Nanoparticles for Multimodal Molecular Imaging / Yanglong Hou, Rui Hao -- Multifunctional Nanoparticles for Cancer Theragnosis / Seulki Lee, Ick Chan Kwon, Kwangmeyung Kim -- Nanoparticles for Combined Cancer Imaging and Therapy / Vaishali Bagalkot, Mi Kyung YU, Sangyong Jon -- Multimodal Imaging and Therapy with Magnetofluorescent Nanoparticles / Jason R McCarthy, Ralph Weissleder -- Gold Nanocages: A Multifunctional Platform for Molecular Optical Imaging and Photothermal Treatment / Leslie Au, Claire M Cobley, Jingyi Chen, Younan Xia -- Theranostic Applications of Gold Nanoparticles in Cancer / Parmeswaran Diagaradjane, Pranshu Mohindra, Sunil Krishnan -- Gold Nanorods as Theranostic Agents / Alexander Wei, Qingshan Wei, Alexei P Leonov -- Theranostic Applications of Gold Core-Shell Structured Nanoparticles / Wei Lu, Marites P Melancon, Chun Li -- Magnetic Nanoparticle Carrier for Targeted Drug Delivery: Perspective, Outlook, and Design / R D K Misra -- Perfluorocarbon Nanoparticles: A Multidimensional Platform for Targeted Image-Guided Drug Delivery / Gregory M Lanza, Shelton D Caruthers, Anne H Schmieder, Patrick M Winter, Tillmann Cyrus, Samuel A Wickline -- Radioimmunonanoparticles for Cancer Imaging and Therapy / Arutselvan Natarajan -- Translational Nanomedicine. Current Status and Future Prospects for Nanoparticle-Based Technology in Human Medicine / Nuria Sanvicens, F̀tima Ferǹndez, J-Pablo Salvador, M-Pilar Marco -- Index.
    Additional Edition: Print version: Nanoplatform-based molecular imaging. Hoboken, N.J. : Wiley, ©2011 ISBN 9780470521151
    Language: English
    Keywords: Electronic books. ; Electronic books. ; Electronic books.
    Library Location Call Number Volume/Issue/Year Availability
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  • 3
    Online Resource
    Online Resource
    San Diego, California :Academic Press,
    UID:
    edoccha_9960073845402883
    Format: 1 online resource (543 p.)
    ISBN: 0-12-407884-2
    Content: Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and d
    Note: Description based upon print version of record. , Front Cover; Cancer Theranostics; Copyright Page; Contents; Preface; Acknowledgments; About the Editors; List of Contributors; I: In Vitro Diagnostics; 1 Cancer Theranostics: An Introduction; Cancer Theranostics: A Definition; Theranostic Cancer Biomarkers; Molecular Imaging in Cancer Theranostics; Imaging-Guided Cancer Therapy; Theranostic Platforms; Challenges and Future Perspectives; References; 2 Genomics-Based Cancer Theranostics; Introduction; Next Generation Sequencing Technology for Genomics-Based Cancer Theranostics; NGS Technology; Available Platforms , Technologies for Oligonucleotide ReplicationSequencing Chemistries and Signal Detection Technologies; Bioinformatics for NGS; What's in an NGS Analysis Pipeline?; Common Errors/False Positives; Cancer-Specific Challenges; Sequencing Applications Focusing on Cancer Theranostics; Identification of Somatic Mutations in Cancers; Familial Genetic Testing; Cancer Cell Lineage Reconstruction via Single-Cell Genomics; Genomics Landscapes in Common Forms of Human Cancers; Overall Picture of Somatic Mutations in Cancer; Characterizing Driver versus Passenger Mutations and Genes; Genetic Heterogeneity , Functions of Key Signaling Pathways in CancerPathways Related to Differentiation; Pathways Related to Cell Growth and Proliferation; Pathways Related to Cell Survival; Pathways Related to Genome Maintenance and Apoptosis; Integration of Genomic Screening for Cancer Theranostics; Case 1:Patterns of Basal Signaling Heterogeneity are Related to Drug Sensitivity; Summary of Reported Work; Presented Opportunities; Case 2:Systematic Approach Helps the Design of Combined Therapy; Summary of Reported Work; Presented Opportunities , Case 3:HCS for Morphological Complexity Identifies Regulators of Switch-Like Transitions between Discrete Cell ShapesSummary of Reported Work; Presented Opportunities; Acknowledgments; Glossary; Abbreviations; References; 3 Proteomics-Based Theranostics; Introduction; Mass Spectrometry Techniques Used for Proteomics Biomarker Discovery; Dynamical Range of Proteins; Blood "Peptidome"; Other Biological Factors; Bioinformatics Analysis Pipeline for Proteomics Biomarker Discovery; Baseline Removal; Denoising/Smoothing; Discrete Wavelet Transform (DWT); Matched Filtration , Savitzky-Golay and Average MovingNormalization; Dividing by a Constant Value; Regression; Quantile; Peak Detection/Identification; Peak Alignment; Biomarker Candidate Identifications; Protein/Peptide Identification; Traditional Biomarker Discovery Methods; Challenges in Proteomics Biomarker Discovery; Existing Single Biomarkers; Knowledge-Integrated Network Biomarker Discovery; Differential Expressions for the Proteins in PCRN; Construction of PCRN; MS-Based Biomarker Discovery; Network Biomarker Identification on PCRN; Clinical Validation of Proteomics Biomarkers; Glossary; Abbreviations , References , English
    Additional Edition: ISBN 0-12-407722-6
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 4
    Online Resource
    Online Resource
    San Diego, California :Academic Press,
    UID:
    edocfu_9960073845402883
    Format: 1 online resource (543 p.)
    ISBN: 0-12-407884-2
    Content: Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and d
    Note: Description based upon print version of record. , Front Cover; Cancer Theranostics; Copyright Page; Contents; Preface; Acknowledgments; About the Editors; List of Contributors; I: In Vitro Diagnostics; 1 Cancer Theranostics: An Introduction; Cancer Theranostics: A Definition; Theranostic Cancer Biomarkers; Molecular Imaging in Cancer Theranostics; Imaging-Guided Cancer Therapy; Theranostic Platforms; Challenges and Future Perspectives; References; 2 Genomics-Based Cancer Theranostics; Introduction; Next Generation Sequencing Technology for Genomics-Based Cancer Theranostics; NGS Technology; Available Platforms , Technologies for Oligonucleotide ReplicationSequencing Chemistries and Signal Detection Technologies; Bioinformatics for NGS; What's in an NGS Analysis Pipeline?; Common Errors/False Positives; Cancer-Specific Challenges; Sequencing Applications Focusing on Cancer Theranostics; Identification of Somatic Mutations in Cancers; Familial Genetic Testing; Cancer Cell Lineage Reconstruction via Single-Cell Genomics; Genomics Landscapes in Common Forms of Human Cancers; Overall Picture of Somatic Mutations in Cancer; Characterizing Driver versus Passenger Mutations and Genes; Genetic Heterogeneity , Functions of Key Signaling Pathways in CancerPathways Related to Differentiation; Pathways Related to Cell Growth and Proliferation; Pathways Related to Cell Survival; Pathways Related to Genome Maintenance and Apoptosis; Integration of Genomic Screening for Cancer Theranostics; Case 1:Patterns of Basal Signaling Heterogeneity are Related to Drug Sensitivity; Summary of Reported Work; Presented Opportunities; Case 2:Systematic Approach Helps the Design of Combined Therapy; Summary of Reported Work; Presented Opportunities , Case 3:HCS for Morphological Complexity Identifies Regulators of Switch-Like Transitions between Discrete Cell ShapesSummary of Reported Work; Presented Opportunities; Acknowledgments; Glossary; Abbreviations; References; 3 Proteomics-Based Theranostics; Introduction; Mass Spectrometry Techniques Used for Proteomics Biomarker Discovery; Dynamical Range of Proteins; Blood "Peptidome"; Other Biological Factors; Bioinformatics Analysis Pipeline for Proteomics Biomarker Discovery; Baseline Removal; Denoising/Smoothing; Discrete Wavelet Transform (DWT); Matched Filtration , Savitzky-Golay and Average MovingNormalization; Dividing by a Constant Value; Regression; Quantile; Peak Detection/Identification; Peak Alignment; Biomarker Candidate Identifications; Protein/Peptide Identification; Traditional Biomarker Discovery Methods; Challenges in Proteomics Biomarker Discovery; Existing Single Biomarkers; Knowledge-Integrated Network Biomarker Discovery; Differential Expressions for the Proteins in PCRN; Construction of PCRN; MS-Based Biomarker Discovery; Network Biomarker Identification on PCRN; Clinical Validation of Proteomics Biomarkers; Glossary; Abbreviations , References , English
    Additional Edition: ISBN 0-12-407722-6
    Language: English
    Library Location Call Number Volume/Issue/Year Availability
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  • 5
    Online Resource
    Online Resource
    Singapore :World Scientific,
    UID:
    almafu_9959232621002883
    Format: 1 online resource (1102 p.)
    ISBN: 1-283-59360-2 , 9786613906052 , 981-4293-68-7
    Content: This review volume integrates the advances in cancer biology, molecular imaging techniques and imaging probes for visualization and quantitative measurement of anatomical, functional, and molecular profiles of cancer. The volume also presents a comprehensive summary of the state-of-the-art technology in molecular imaging probe design and applications in radionuclide (PET and SPECT), magnetic resonance (MR), optical (fluorescence, Raman, photoacoustic), ultrasound, CT, and multimodality imaging. Bringing together the fundamentals of molecular imaging, and the basic principles of each molecular
    Note: Description based upon print version of record. , Contents; List of Contributors; Preface; Session I: Fundamentals of Molecular Imaging; Chapter 1 Introduction to Cancer Biology Ramasamy Paulmurugan; 1. Introduction; 2. Genetics of Cancer Cells; 2.1. Molecular mechanisms in normal and cancer cells; 3. Incidence of Cancer; 4. Cancer Cells and Tissues; 5. Biological Networks in Regulating the Cellular Signaling Pathways; 6. Focus on Diagnostic and Therapeutic Strategies for Cancer; 6.1. Preventive cancer vaccines; 6.2. Therapeutic cancer vaccines; 7. Molecular Imaging Tools for the Early Diagnosis of Cancer; 7.1. Ultrasound (Ultrasonography) , 7.2. Computerized tomography (CT)7.3. Magnetic resonance imaging (MRI); 7.4. PET and SPECT; 8. Drug Development for Cancer Treatment; 8.1. Molecular therapeutic targets of cancer cells; 8.2. Molecularly targeted therapy using small molecule drugs; 8.3. Antibody-mediated inhibition of receptor tyrosine kinases; 9. Cancer Treatment by Targeting Death Receptors; 10. Future Approaches in Cancer Diagnostics and Therapeutics; References; Chapter 2 Molecular Imaging Instrumentation Craig S. Levin; 1. Introduction; 2. Positron Emission Tomography (PET); 2.1. Introduction; 2.2. PET instrumentation , 2.3. PET methodology2.4. PET system performance issues; 2.5. Advances in PET system technology; 3. Single Photon Emission Computed Tomography (SPECT); 3.1. Introduction; 3.2. SPECT instrumentation; 3.3. SPECT methodology; 3.4. SPECT System Performance Issues; 3.5. Advances in SPECT System Technology; 4. Optical Fluorescence Imaging (FLI); 4.1. Introduction; 4.2. Tissue optical properties: Absorption and scatter of light; 4.3. Optical versus radionuclide imaging; 4.4. Optical versus radionuclide tomography; 4.5. FLI instrumentation; 4.6. FLI methodology; 4.7. FLI system performance issues , 4.8. FLI versus BLI4.9. Advances in non-invasive in vivo FLI system technology; 4.10. Invasive in vivo FL microscopy methods; 5. Magnetic Resonance Imaging (MRI); 5.1. Introduction; 5.2. Basics of nuclear magnetic resonance (NMR); 5.3. MRI instrumentation; 5.4. MRI methodology; 5.5. MRI performance issues; 6. Multiple Modality Molecular Imaging of Living Subjects; 7. Can Molecular Imaging Instrumentation be Further Improved?; Enhance contrast resolution: Increase signal and reduce background; Advance spatial resolution; Improve molecular imaging signal quantification; References , Chapter 3 Molecular Imaging Data Analysis F. Habte1. Introduction; 2. General Concepts, Notation and Terminology; 2.1. Image formation; 2.2. Image basics; 2.2.1. Pixel and voxel; 2.2.2. Matrix size and spatial resolution; 2.2.3. Pixel value and depth; 2.2.4. Image representation and file formats; 2.3. Image display; 3. Image Quality; 3.1. Definition and metrics; 3.2. Contrast; 3.3. Resolution; 3.4. Noise; 3.5. Artifacts and distortion; 4. Image Data Acquisition Process; 4.1. Acquisition workflow; 4.2. Image acquisition options; 4.3. Image types and dimensions , 5. Image Processing and Visualization , English
    Additional Edition: ISBN 981-4293-67-9
    Language: English
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